Publications by authors named "Gustavo Salgado Duque"
Background: Takotsubo syndrome (TTS) is an acquired form of cardiomyopathy. National Brazilian data on this condition are scarce. The Takotsubo Multicenter Registry (REMUTA) is the first to include multicenter data on this condition in Brazil.
View Article and Find Full Text PDFBackground The role of Ser49Gly beta1-adrenergic receptor genetic polymorphism (ADBR1-GP-Ser49Gly) as a predictor of death in heart failure (HF) is not established for the Brazilian population. Objectives To evaluate the association between ADBR1-GP-Ser49Gly and clinical outcomes in individuals with HF with reduced ejection fraction. Methods Secondary analysis of medical records of 178 patients and genotypes of GPRβ1-Ser49Gly variants, classified as Ser-Ser, Ser-Gly and Gly-Gly.
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- - The study investigates the relationship between ACE gene polymorphisms and clinical outcomes in heart failure patients in Rio de Janeiro, focusing on the frequency of these polymorphisms and their effects on echocardiographic measurements.
- - Among 99 patients analyzed, the DD genotype was the most prevalent, showing the highest rates of worsening heart function compared to DI and II genotypes in terms of left ventricular sizes and ejection fraction.
- - Findings suggest that patients with the DD genotype experience more significant declines in heart function over time, indicating that genetic profiling may help in stratifying risk for heart failure outcomes.
Background: The role of angiotensin-converting enzyme genetic polymorphisms as a predictor of echocardiographic outcomes on heart failure is yet to be established. The local profile should be identified so that the impact of those genotypes on the Brazilian population could be identified. This is the first study on exclusively non-ischemic heart failure over a follow-up longer than 5 years.
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