Publications by authors named "Gustavo R Alvira-Arill"
Introduction: Daptomycin (DAP) is a cyclic lipopeptide that exhibits potent in vitro activity against many drug-resistant gram-positive organisms, including methicillin-resistant (MRSA) and vancomycin-resistant enterococci (VRE). Despite substantial reports evaluating the clinical outcomes of DAP within the adult population, real-world data are lacking in children. The primary goal of this evaluation was to describe the clinical characteristics and outcomes of DAP use in pediatric patients across a wide range of infections.
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- Use of mixed-oil intravenous fat emulsions (MO-IFE) reduces biofilm formation by Candida albicans and lowers the rate of catheter-related bloodstream infections (CR-BSIs) compared to soybean-oil emulsions (SO-IFE).
- Research involved gene analysis of C. albicans in different IFE environments and a 5-year study on pediatric CR-BSI cases to see how IFE choice influenced Candida species distributions.
- Findings suggest that MO-IFE inhibits biofilm and hyphal growth in C. albicans through a UME6-dependent pathway, with a slight increase in non-albicans Candida infections noted, though not statistically significant.
Study Objective: To compare rates of catheter-related bloodstream infections (CR-BSI) in pediatric patients who received parenteral nutrition (PN) with either soybean oil-based intravenous fat emulsion (SO-IFE) or mixed oil-IFE (MO-IFE). We hypothesized that the use of MO-IFE would be independently associated with reduced infection rates compared with SO-IFE.
Design: Retrospective cohort study.