Serum selenium and glutathione peroxidase-3 activity: biomarkers of systemic inflammation in the critically ill?

Objectives: To confirm the influence of systemic inflammatory response syndrome (SIRS) on selenium (Se) levels and prospectively evaluate the relationship between serum Se concentration [Se], glutathione peroxidase activity [GPx-3] and injury severity in patients at the time of intensive care unit (ICU) admission.

Design: Prospective, observational study.

Setting: Multidisciplinary University Hospital ICU.