Publications by authors named "Gustavo M Lamas"
Article Synopsis
- Natalizumab, an anti-integrin monoclonal antibody, is used for autoimmune disorders like multiple sclerosis, but it can rarely cause liver injury, typically presenting as non-severe acute hepatitis after the first or subsequent doses.
- A case study of a 60-year-old woman showed she developed jaundice and severe liver enzyme increases just one day after her first natalizumab infusion, with lab tests revealing signs of drug-induced liver injury.
- The patient was treated with oral prednisone, leading to her progressive recovery and normalization of liver function, highlighting the need for physicians to monitor for early-onset hepatitis in new natalizumab patients, particularly women with multiple sclerosis.
Rapidly progressive dementia (RPD) is a rare neurological disorder. Drug toxicity is among the differential diagnoses, including the use of lithium, in which an overdosage might cause cognitive dysfunction. Clinical suspicion, laboratory confirmation, and drug interruption are key points in the management of lithium intoxication.
View Article and Find Full Text PDFMutations in the SPG4 gene (SPG4-HSP) are the most frequent cause of hereditary spastic paraplegia, but the extent of the neurodegeneration related to the disease is not yet known. Therefore, our objective is to identify regions of the central nervous system damaged in patients with SPG4-HSP using a multi-modal neuroimaging approach. In addition, we aimed to identify possible clinical correlates of such damage.
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