Publications by authors named "Gustavo Lugo-Goytia"
Changes in pulmonary mechanics from supine to prone position measured through esophageal manometry in critically ill patients with COVID-19 severe acute respiratory distress syndrome.
Med Intensiva (Engl Ed)
July 2024
Article Synopsis
- The study examines how switching from a supine to a prone position affects lung mechanics in mechanically ventilated COVID-19 patients with ARDS.
- Significant improvements were noted in lung stress, strain, and elastance metrics after 24 hours in the prone position.
- Despite these changes, no significant differences were found in driving pressure or transpulmonary pressure between the two positions.
Metformin pharmacokinetics in a liquid extemporaneous formulation from commercial tablets was determined in paediatric patients. A randomized, transversal clinical trial was conducted in 34 children and adolescents between 7 and 17 years of age. 17 children were randomized to take metformin in the liquid formulation and, after a 1-week wash period, a 500 mg metformin tablet was administered to them.
View Article and Find Full Text PDFLittle literature exists about critically ill patients with coronavirus disease 2019 (COVID-19) from Latin America. Here, we aimed to describe the clinical characteristics and mortality risk factors in mechanically ventilated COVID-19 patients from Mexico. For this purpose, we recruited 67 consecutive mechanically ventilated COVID-19 patients which were grouped according to their clinical outcome (survival vs.
View Article and Find Full Text PDFA MULTIVARIATE PROGNOSTIC SCORE FOR PREDICTING MORTALITY OF ACQUIRED IMMUNODEFICIENCY SYNDROME PATIENTS WITH HYPOXEMIC RESPIRATORY FAILURE AND PNEUMOCYSTIS JIROVECI PNEUMONIA.
Rev Invest Clin
February 2020
Background: Severe hypoxemic respiratory failure (SHRF) due to Pneumocystis jiroveci pneumonia (PJP) in AIDS patients represents the main cause of admission and mortality in respiratory intensive care units (RICUs) in low- and middle-income countries.
Objective: The objective of this study was to develop a predictive scoring system to estimate the risk of mortality in HIV/AIDS patients with PJP and SHRF.
Methods: We analyzed data of patients admitted to the RICU between January 2013 and January 2018 with a diagnosis of HIV infection and PJP.
Article Synopsis
- Dexmedetomidine is a sedative and analgesic drug that's effective due to its ability to bind to α2 adrenergic receptors, and researchers developed a method to measure its levels in dried blood spots.
- The drug was extracted using liquid extraction and analyzed using a specialized liquid chromatography coupled with mass spectrometry, with testing showing good linearity and stability.
- The method was successfully validated by quantifying dexmedetomidine levels in six young patients who received a specific dosage during minor surgeries, with drug concentrations measured ranging from 76 to 868 pg/mL.
Article Synopsis
- Dexmedetomidine (DEX), a sedative and analgesic not FDA-approved for kids, is increasingly used in pediatric anesthesia; this study aimed to explore its pharmacokinetics in Mexican children aged 2-18 during outpatient surgeries.
- The study included 30 children who received a 0.7 μg/kg DEX infusion, with blood samples analyzed to create population PK-PD models using sophisticated laboratory techniques.
- Findings indicate that DEX shows a 2-compartment pharmacokinetic model in this age group, revealing lower clearance rates and significant reductions in blood pressure and heart rate, suggesting dosage adjustments are needed for pediatric patients.
Acute Respiratory Distress Syndrome Secondary to Influenza A(H1N1)pdm09: Clinical Characteristics and Mortality Predictors.
Rev Invest Clin
July 2017
Background: Acute respiratory distress syndrome secondary to influenza A(H1N1)pdm09 virus is the leading cause of death among this patient population. Expanding the knowledge of its course and predictors of mortality is relevant to decision making. We aimed to describe the clinical characteristics and identify factors associated with mortality in patients with acute respiratory distress syndrome secondary to influenza A(H1N1)pdm09 during the 2013-2014 influenza season.
View Article and Find Full Text PDFIn the well-known Berlin definition of acute respiratory distress syndrome (ARDS), there is a recommended adjustment for arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FIO2) at altitude, but without a reference as to how it was derived.
View Article and Find Full Text PDFBackground: To develop a population pharmacokinetic model of gentamicin in children with complicated severe malnutrition and to study the influence of covariates (weight and age) on pharmacokinetic indices. In addition, we use the model to perform Monte Carlo simulations to explore the efficacy of several dosage regimens.
Methods: Twenty-six children with severe complicated malnutrition were studied.
Background: Most of bayesian pharmacokinetic studies and the influence of clinical variables have been carried out in adults.
Purpose: The aim was to estimate population-based pharmacokinetic of valproic acid (VPA) and to determine the effect of treatment and additional disease on its performance in children with epilepsy.
Material And Methods: For the study steady-state serum concentrations of VPA were determined from 108 epileptic patients (44 females and 64 males) who were receiving the anticonvulsant as main drug of treatment with age range since 1 to 16 years (median 4y, 6m) and weight since 5.