Publications by authors named "Gustavo Gavazzoni Blume"
To investigate the effect of transplantation of stem cells from the bone marrow mononuclear cells (BMMC) associated with 15d-PGJ2-loaded nanoparticles in a rat model of chronic MI. Chronic myocardial infarction (MI) was induced by the ligation of the left anterior descending artery in 40 male Wistar rats. After surgery, we transplanted bone marrow associated with 15d-PGJ2-loaded nanoparticle by intramyocardial injection (10 cells/per injection) seven days post-MI.
View Article and Find Full Text PDFBackground: The purpose of this study was to assess the utility of a handheld device (HH) used during common daily practice and its agreement with the results of a standard echocardiography study (STD) performed by experienced sonographers and echocardiographer.
Methods: A prospective follow-up was conducted in an adult outpatient echocardiography clinic. Experienced sonographers performed the STD and an experienced echocardiographer performed the HH.
Article Synopsis
- Myocardial infarction (MI) is a leading cause of cardiovascular death and heart failure globally, and recent studies explore the use of bone marrow stem cells (BMSC) and human amniotic membrane (hAM) as therapies to improve heart function post-MI.
- In a rat model, MI was induced, and rats with reduced heart function were treated with either BMSC, hAM, or left as a control group after coronary occlusion.
- After 30 days, both BMSC and hAM groups showed significant improvements in heart function and structure compared to the control group, indicating potential benefits of these therapies in enhancing cardiac recovery through mechanisms like angiogenesis and heart cell regeneration.
Pulmonary thromboembolism in conjunction with intracavitary thrombus caused by severe acute respiratory syndrome coronavirus-2 infection in a patient living with human immunodeficiency virus.
Rev Soc Bras Med Trop
June 2021
Approximately one-third of patients with coronavirus disease 2019 (COVID-19) present with coagulation disorders and hematological changes. However, the clinical manifestations of COVID-19 and prognoses of people living with human immunodeficiency virus (HIV) remain controversial. This study reports the case of a 27-year-old HIV-infected man who regularly used antiretroviral medications, had no other comorbidities and was admitted for acute respiratory distress syndrome caused by COVID-19.
View Article and Find Full Text PDFObjective: myocardial infarction (MI) remains the leading cause of death worldwide. Cell-based therapies have become potential therapeutic approaches, attempting to recover the contractility of necrotic cardiomyocytes. In the present study, we aimed to systematically evaluate experimental studies on the use of tissue-engineered amniotic membrane (hAMC) in MI treatment.
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