Publications by authors named "Gustavo F Galvao"
Objective: The biological behavior of Cerebral Cavernous Malformation (CCM) is still controversial, lacking a clear-cut signature for a mechanistic explanation of lesion aggressiveness. In this study, we evaluated the predictive capacity of genetic variants concerning the aggressive behavior of CCM and their implications in biological processes.
Methods: We genotyped the variants in VDR, VDR, VDR, PTPN2 and FCGR2A genes using TaqMan Genotyping Assays in a cohort study with 103 patients, 42 of whom had close follow-up visits for 4 years, focusing on 2 main aspects of the disease: (1) symptomatic events, which included both intracranial bleeding or epilepsy, and (2) the onset of symptoms.
Article Synopsis
- The study investigates how the brain, particularly the prefrontal cortex (PFC), recovers after injury and focuses on low-frequency oscillatory activity (LFO) as a key factor in this process.
- Data were collected from a patient, E.L., who had significant PFC damage due to an accident, and assessments included various clinical and neuropsychological tests to understand the relationship between LFO and cognitive function.
- Findings revealed that LFO activity varied with movement and brain hemisphere recruitment, suggesting potential targets for neuromodulation to improve executive functions, highlighting differences between E.L. and historical cases like Phineas Gage regarding cognitive impairments.