Publications by authors named "Gustav Wikberg"
T cells expressing the cutaneous lymphocyte antigen (CLA) mediate pathogenic inflammation in atopic dermatitis (AD). The molecular alterations contributing to their dysregulation remain unclear. With the aim to elucidate putative altered pathways in AD we profiled DNA methylation levels and miRNA expression in sorted T cell populations (CD4, CD4CD45RA naïve, CD4CLA, and CD8) from adult AD patients and healthy controls (HC).
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- Atopic dermatitis (AD) is a chronic inflammatory disease triggered by allergens, and this study aimed to analyze IgE reactivity in patients with AD to various allergens.
- IgE reactivity was found in 92% of severe and 83% of moderate AD patients, with a higher sensitivity to cat and house dust mites in the severe group, indicating distinct allergen profiles.
- The findings suggest that differences in molecular sensitization profiles between severe and moderate AD patients could lead to future research on the underlying factors contributing to these differences.