Publications by authors named "Gustafsson S"

Background: We previously reported significant correlations between a direct measure of insulin sensitivity (IS) and blood levels of proteins measured using the Proximity Extension Assay (PEA) in two European cohorts. However, protein correlations with IS within non-European populations, in response to short-term interventions that improve IS, and any causal associations with IS have not yet been established.

Methods: We measured 1,470 proteins using the PEA in the plasma of 1,015 research participants at Stanford University who underwent one or more direct measures of IS.

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  • The study investigates the side effects of COVID-19 vaccinations and infections, focusing on the benefits of self-reporting symptoms through a digital system called Symptoms.
  • Researchers aimed to understand how this system can capture patient-reported outcomes, which vary in importance depending on individual needs.
  • A total of 731 participants used the Symptoms system to track their health-related quality of life and symptoms, highlighting the relevance of personal experiences in monitoring vaccine side effects.
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  • This study investigated the relationship between transportation noise and atrial fibrillation (AF) using data from 11 Nordic cohorts, totaling over 161,000 participants.
  • Researchers found that higher road traffic noise exposure is linked to an increased risk of developing AF, particularly in women and overweight individuals.
  • Aircraft noise also showed a potential association with AF risk, while railway noise did not appear to be related; overall, road and aircraft noise combined raised the risk significantly.
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  • Genome-wide association studies have found numerous genetic loci linked to glycemic traits, but connecting these loci to specific genes and biological pathways remains a challenge.
  • Researchers conducted meta-analyses of exome-array studies across four glycemic traits, analyzing data from over 144,000 participants, which led to the identification of coding variant associations in more than 60 genes.
  • The study revealed significant pathways related to insulin secretion, zinc transport, and fatty acid metabolism, enhancing understanding of glycemic regulation and making data available for further research.
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Cell identities are defined by intrinsic transcriptional networks and spatio-temporal environmental factors. Here, we explored multiple factors that contribute to the identity of adipose stem cells, including anatomic location, microvascular neighborhood, and sex. Our data suggest that adipose stem cells serve a dual role as adipocyte precursors and fibroblast-like cells that shape the adipose tissue's extracellular matrix in an organotypic manner.

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Aims: In patients with heart failure, treatment patterns in the last years of life have not been assessed at large scale. We aimed to assess whether heart failure treatment patterns up to 5 years prior to death changed over time.

Methods And Results: In a cohort study covering the whole Swedish population, we assessed all heart failure patients who died between 1 July 2007 and 31 December 2020 for evidence-based treatments.

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Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent first myocardial infarction and design relevant prediction models. Here, we constructed a new case-cohort consortium of 2,018 persons without prior cardiovascular disease from six European cohorts, among whom 420 developed a first myocardial infarction within 6 months after the baseline blood draw.

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Imbalances in electrolyte concentrations can have severe consequences, but accurate and accessible measurements could improve patient outcomes. The current measurement method based on blood tests is accurate but invasive and time-consuming and is often unavailable for example in remote locations or an ambulance setting. In this paper, we explore the use of deep neural networks (DNNs) for regression tasks to accurately predict continuous electrolyte concentrations from electrocardiograms (ECGs), a quick and widely adopted tool.

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Aim: To examine parents' perceptions of care quality at child health centres. Specific objectives were to examine parents' perceptions of the care received and the subjective importance of such care. Furthermore, to examine the relationship between parents' sociodemographic characteristics and the perceptions of care quality.

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  • This study looked at people in Sweden who had kidney disease but didn't know it, to see how often they got diagnosed and treated.
  • Out of nearly 100,000 people with undiagnosed kidney disease, only about 1 in 3 were diagnosed in five years, and not many were treated with the right medications.
  • If all of them had received proper treatment, many deaths and heart problems could have been avoided, showing there's a big opportunity to help these patients better.
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  • The study investigates the gene expression changes in vascular cells during atherosclerosis progression, emphasizing the limited understanding of their clinical significance.
  • It utilizes single-cell RNA sequencing data from both mouse models and human tissue to identify various cell subtypes involved in advanced atherosclerosis and symptomatic carotid plaques.
  • The findings highlight the association of specific gene-regulatory networks with coronary artery disease severity, suggesting pathways that may be targeted for therapeutic strategies.
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Background: Heart failure guidelines have recently introduced a narrow category with mildly reduced left ventricular ejection fraction (LVEF) (heart failure with mildly reduced ejection fraction; LVEF 41%-49%) between the previous categories of reduced (heart failure with reduced ejection fraction; LVEF ≤40%) and preserved (heart failure with preserved ejection fraction; LVEF ≥50%) ejection fraction. Grouping of continuous measurements into narrow categories can be questioned if their variability is high.

Methods And Results: We constructed a cohort of all 9716 new cases of chronic heart failure with an available LVEF in Stockholm, Sweden, from January 1, 2015, until December 31, 2020.

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Background: This article provides an update of the Reflective Practice Questionnaire (RPQ). The original RPQ consisted of 40-items with 10-sub-scales. In this article, the RPQ is streamlined into a 10-item single reflective practice construct, and a 30-item extended version that includes additional sub-scales of confidence, uncertainty/stress, and work satisfaction.

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  • This study looked at how a medicine called evolocumab helps lower bad cholesterol levels in patients over time.
  • The study included over 2,300 patients in Sweden who were given evolocumab between July 2015 and May 2020.
  • Results showed high rates of patients sticking to their medication, with bad cholesterol levels dropping significantly for those who took it, including those with heart disease.
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Aims: This study aimed to characterize a contemporary population with subtypes of incident or prevalent heart failure (HF) based on reduced (HFrEF), mildly reduced, or preserved (HFpEF) left ventricular ejection fraction (LVEF) and to assess how outcomes, healthcare, treatments, and healthcare costs vary between each subtype of incident HF.

Methods And Results: Using Swedish data from the CardioRenal and Metabolic disease Heart Failure (CaReMe HF) study, updated to cover a more recent time period, this population-based study characterized patients from Stockholm County, Sweden, with incident HF (patients with a first HF diagnosis between 1 January 2015 and 31 December 2019) or prevalent HF (patients with a first HF diagnosis before 1 January 2020). Patients with incident HF had LVEF measured by echocardiography within ±90 days of their first HF diagnosis, and patients with prevalent HF within 5 years prior to the index date.

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Key Points: Newly detected, moderately progressed CKD is associated with high clinical risks and health care costs. Most patients with moderately progressed CKD do not have diabetes and are at the same clinical risk as those with diabetes. Substantial inertia with kidney-protective treatment is observed when moderately progressed CKD is detected.

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Aims: To determine what kinds of birth-related experiences of success and failure are described by the participants, and whether there are differences according to fear of childbirth and parity. Studying these experiences is important for understanding the psychological mechanisms behind different childbirth experiences and their impact on maternal mental well-being.

Methods: This was a longitudinal mixed methods study.

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This study aimed to explore the experiences of older migrants' (70+) access to and participation in different meeting places. Qualitative interviews were conducted with participants originating from Finland and four countries in the Western Balkans: Bosnia- Herzegovina, Croatia, Montenegro, and Serbia. The participants used everyday places in the neighborhood, which were not primarily meant to be meeting places, to create and uphold social contacts.

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Background: Proteomic profiling could potentially disclose new pathophysiological pathways for cardiovascular diseases (CVD) and improve prediction at the individual level. We therefore aimed to study the plasma protein profile associated with the incidence of different CVDs.

Methods: Plasma levels of 245 proteins suspected to be linked to CVD or metabolism were measured in 4 Swedish prospective population-based cohorts (SIMPLER [Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research], ULSAM (Uppsala Longitudinal Study of Adult Men), EpiHealth, and POEM [Prospective Investigation of Obesity, Energy Production, and Metabolism]) comprising 11 869 individuals, free of CVD diagnoses at baseline.

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In this study, the long-term mortality effects associated with exposure to PM (particles with an aerodynamic diameter smaller than or equal to 10 µm), PM (particles with an aerodynamic diameter smaller than or equal to 2.5 µm), BC (black carbon), and NO (nitrogen oxides) were analyzed in a cohort in southern Sweden during the period from 1991 to 2016. Participants (those residing in Malmö, Sweden, born between 1923 and 1950) were randomly recruited from 1991 to 1996.

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Background: Telephone nursing involves triage, advice, and care management provided by a nurse over the telephone. The telephone nursing dialogue process has been used clinically in telephone nursing in Sweden for several years to structure the communication and ensure a safe assessment and advice. Studies are needed to determine whether there is sufficient scientific evidence to support the method.

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  • Human plasma proteins are crucial as clinical biomarkers and potential drug targets, and studying their genetic variants can help us understand their abundance.
  • The study conducted a meta-analysis across nearly 23,000 individuals to identify genetic variants associated with 92 plasma proteins linked to cardiometabolic conditions, discovering 503 significant variants.
  • Notably, sex differences were observed in 23.5% of the identified variants, and further analysis suggested causal links between certain proteins and various health traits, providing insight into their roles in cardiometabolic diseases.
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A recently developed method for analyzing the thermal conductivity vs depth variation near a sample surface has been extended to include inhomogeneous samples with anisotropy. If not considered, the anisotropy ratio in the sample structure can distort the depth-position data of the original test method. The anisotropy ratio is introduced in the original computational scheme in order to improve the depth-position estimations for inhomogeneous structures with anisotropy.

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Background: Heat waves impact the health of older adults, and occupations are important for health. An overview of research focussed on older adults' occupations in heat waves can be useful for occupational therapy practice.

Objective: To identify what the literature shows about older adults' experience and performance of, and participation in, occupations in heat waves.

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