Psycho-educational support for relatives of people with a recent diagnosis of mild to moderate dementia: an evaluation of a 'Course for Carers'.

Currently there are 820,000 people with dementia in the UK, a figure projected to reach 1.7 million by 2050. Policy and practice emphasis on early intervention in dementia and support of family carers foreground a need to explore service efficacy for relatives of those with a recent diagnosis.

Screening for dementia in primary care: a review of the use, efficacy and quality of measures.

Background: Despite evidence that early identification of dementia is of growing policy and practice significance in the U.K., limited work has been done on evaluating screening measures for use in primary care.

Endotoxin-induced uveitis in the rat: observations on altered vascular permeability, clinical findings, and histology.

A single intraperitoneal dose of endotoxin (lipopolysaccharide or LPS) induces an acute inflammatory response in the uveal tract of rats. This inflammation is characterized by a breakdown of the blood/aqueous barrier within 3 hr after the LPS and the subsequent development of clinical disease and a cellular infiltrate. Early change in vascular permeability, clinical, and pathological changes were dose dependent with the two highest doses (100 micrograms or 500 micrograms) producing more severe pathology.

Rhodamine B as a test molecule in intraocular dynamics.

Rhodamine B is a lipid-soluble, nontoxic dye that fluoresces at longer wavelengths than fluorescein and consequently is detectable at lower concentrations in the ocular tissues. Its dynamics after topical and systemic administration are similar to those of lipid-soluble drugs.

Neural remodeling following experimental surgery of the rabbit cornea.

Wounding of the cornea results in extensive damage to the innervation that must be repaired to restore its normal structure and function. Four types of experimental wounds were produced in the corneas of young albino rabbits: 180 degrees penetrating perilimbal incisions, 4-mm central circular keratectomies and keratotomies, and radial keratotomies. Following perilimbal incisions, the denervated half of the cornea was reinnervated primarily by regenerating nerves that penetrated the limbal scar tissue.

Endothelial cell counts after epikeratophakia surgery.

We used specular microscopy to study the corneal endothelium of eight aphakic patients who had undergone epikeratophakia. The average post-operative period was 16 months with a range of 12 to 18 months. Corneal thickness increased from 0.

Endophthalmitis after penetrating keratoplasty.

Of 445 eyes (305 of which were aphakic) that underwent penetrating keratoplasty, 11 developed endophthalmitis, three immediately after surgery, two after subsequent secondary surgery, and six after late ulceration of the transplanted cornea. The diagnosis was based clinically on the loss of the red reflex and vitreous opacification, and was confirmed by culture of vitreous aspirate. All patients who developed endophthalmitis were aphakic and had received corticosteroids at the time of infection; most had undergone previous ocular surgery.

Abnormal immune responses in the ocular presentation of Wiskott-Aldrich syndrome.

Wiskott-Aldrich syndrome is an x-linked disorder characterized by a triad of thrombocytopenia, eczema, and recurrent infections. Until recently, survival into the second decade was rare. In the last few years, a better understanding of the syndrome has been achieved, and earlier recognition and newer modes of treatment have improved life.

Ocular albumin fluorophotometric quantitation of endotoxin-induced vascular permeability.

Bacterial endotoxin (lipopolysaccharide; LPS) is known to alter systemic vascular permeability, but this effect is difficult to monitor and quantitate in vivo. The ocular vessels of the rabbit are particularly sensitive to LPS. Using a slit lamp equipped with a fluorophotometer, we have adapted a method to quantitate endotoxin-induced ocular vascular permeability by measuring the accumulation of fluorescein isothiocyanate-conjugated albumin into the anterior chamber of the eye.

Cardiac output following adrenomedullary deprivation.

This study was performed to determine whether or not the adrenal medulla supports cardiac output and total peripheral vascular resistance after acute hypovolemia. Two groups of anesthetized dogs were studied. The first group underwent right adrenalectomy and the second, left adrenal denervation in addition.