Impact of repeated abdominal surgery on wound healing and myeloid cell dynamics.

Background: Even though wound dehiscence is a surgical complication, under certain medical conditions, repetition of the laparotomy (LT) (relaparotomy) can become inevitable. In addition to the risks associated with this surgical operation, relaparotomy can interfere with the tissue healing and contribute to the development of chronic wounds.

Methods: In an experimental relaparotomy wounding model, this study investigated the impact of repeated surgery on wound healing and on the immune cells of myeloid origin.

Poly(HEMA)--based embolic material in endovascular surgery of liver.

Physico-chemical and medico-biological methods, including hematology and cytology, were used in an evaluation of properties of poly(2-hydroxyethyl methacrylate) (poly(HEMA))-based embolic material indicated in the occlusion of branches of hepatic artery of patients with focal alterations of the liver. The elastographic method helped in predicting mechanical properties of the hydrogel material. Poly(HEMA) was mechanically stable for endovascular applications, exhibited no significant loss in elasticity and possessed consistency resembling the soft tissue of the organism.

[Sex correction in testicular feminization syndrome].

From 1993 to 2000 the authors observed 10 patients with testicular feminization. In spite of existent highly informative methods, early diagnosis of the genesis of abnormal sexual differentiation is not easy, it requires time. Treatment policy varied with the form of testicular feminization.

[Secondary obstructive megaureter with detrusor-sphincter dyssynergia in children].

29 boys with secondary obstructive megaureter due to detruzor-sphincter dyssinergy were treated in 1989-1998. To normalize detruzor-sphincter relations, transurethral sphincterotomy was made in 25 boys. Later, 16 of them underwent autocatheterization of the urinary bladder and received alpha-adrenoblockers.

[Variant of vesico-ureteral reflux surgical treatment in children].

Cowen's operation has been performed on 77 ureters in 52 children with vesicoureteral reflux of degree II-IV. Positive results were observed in 97.7% of the operated children.

Targeted chemoembolization of tumors with poly(2-hydroxyethyl methacrylate) particles.

Thirty-four patients suffering from various kinds of tumors, including metastasis, were treated by selective embolization with both spherical and cylindrical poly(2-hydroxyethyl methacrylate) [poly(HEMA)] particles and topical chemotherapy. Treatment of a patient with carcinoid metastases in the liver is discussed. Immediately after embolization, 5-fluorouracil, and later, doxorubicin and Lipiodol, were selectively infused into the tumorous tissue for approximately 1 week.

[Comparative features of antireflux surgery, causes of recurrence of vesicoureteral reflux in children].

2560 children with the reflux were observed, 224 of them were operated. Long-term positive results after Koan's operation were noted in 97.7% of the patients.

[Long-term results of plastic surgery in hydronephrosis in children].

94 children (109 kidneys) with congenital hydronephrosis were treated in 1989-1997. 67 of them underwent 76 plastic operations: Andersen-Hynes operation on the ureteropelvic segment without pelvic resection (n = 53), antevasal pyelopyelo- and ureteropyeloanastomosis (n = 18), ureteropyelolysis (n = 5). Excellent, good and satisfactory results were obtained in 16.

[Hemostasis disorders after resection of liver and approaches to their prevention and correction].

Second- or third-degree dysfunction of hepatocytes was the most frequent (47.9%) disorder in the hemostasis system on the first-second days after extensive resection of the liver, whereas after economic resection this disorder was observed in only 5.5% patients.

Poly (2-hydroxyethyl methacrylate) particles for management of hemorrhage of complicated origin: treatment of hemobilia.

Poly (2-hydroxyethyl methacrylate) (PHEMA) particles of cylindrical and spherical shape were developed as a preparation for tumor treatment or control of hemorrhage by blocking their blood supply. In this report, PHEMA particles were used for the management of hemobilia, that is, bleeding into biliary passages. The origin of hemobilia in 31 patients was localized by selective angiography.

Surgical treatment of giant cavernous hemangioma liver.

In the past five years, 16 adults (10 females, age 25-61 years, mean 48) with giant cavernous hemangioma of the liver measuring 15-31 cm (mean-19) underwent surgery in a single Institution. Diagnosis was made with the help of multimodal investigations- ultrasound (US), computed tomography (CT), hepatic angiography, hepatic scintigraphy and fine needle biopsy. Ultrasound and CT had sensitivities of 69% and 82% respectively.

[The use of the M-cholinomimetic test in predicting treatment efficacy in neurogenic bladder dysfunctions].

Presented are the first-hand correlations between therapeutic responses and hyper-response of the bladder of M-cholinomimetic drugs made by the authors on the basis of a follow-up of 98 children with hyper-reflex dysfunctions of the urinary bladder. The study revealed a definite relationship: the more pronounced hyper-response was, the more difficult it was to get a persistent effect of recovered function of the bladder. Out of 63 M-cholinomimetic-positive patients, the effective response was noted in 61.

Poly(2-hydroxyethyl methacrylate) beads for the preoperative endovascular occlusion of branches of the hepatic artery in focal alterations of the liver.

Spherical particles of porous poly(2-hydroxyethyl methacrylate) have been used in the treatment of patients suffering from focal alterations of the liver, namely haemangioma and hypervascular tumour. The treatment consisted of the preoperative endovascular occlusion of branches of the hepatic artery using these spherical particles, and was followed by an operation. The main merit of the preoperative occlusion of blood vessels is that it substantially reduces blood loss during surgery.

[Debatable problems of intravascular dilatation of the brachiocephalic artery].

Roentgen--guided endovascular dilatation (RED) was conducted in 23 patients with atherosclerotic stenoses of branches of the arch of the aorta, in 20 with stenoses of the subclavian artery, and in 3 with stenoses of the brachiocephalic trunk. Before dilatation the patients had a systolic pressure gradient of 25 to 55 mm Hg in the region of the stenosis and constriction of the arterial lumen by 40 to 80%. Systolic pressure gradient disappeared completely in 17 cases and persisted at a level of 10 to 40 mm Hg in 7 cases.

[The morphological changes in liver hemangiomas and in organ tissue after endovascular occlusion of branches of the hepatic artery based on the results of a study of surgical material].

30 haemangiomas and surrounding liver tissues removed surgically are studied histologically. 11 patients underwent endovascular occlusion of the hepatic artery peripheral branches at various intervals before the operations. The lack of reaction of the vascular wall to the X-ray noncontrast emboli and minimal reaction to the X-ray contrast emboli were found.

[Preoperative roentgeno-endovascular occlusion of the branches of the hepatic artery in focal lesions of the liver].

Preoperative roentgenendovascular occlusion of branches of the hepatic artery was performed in 22 patients with local alterations of the liver. The occlusion was fulfilled with artificial emboli from hydrogel of a spherical and cylindrical form. Metallic spirals were additionally introduced into the artery lumen to 13 patients.