[Prognosis criteria of optical coherence tomography angiography for the long-term efficacy of anti-VEGF therapy of neovascular age-related macular degeneration].

Purpose: The study aimed to determine the most significant optical coherence tomography angiography (OCTA) parameters in terms of predicting anti-VEGF therapy effectiveness during long-term (3-year) follow-up of patients with neovascular age-related macular degeneration (nAMD).

Material And Methods: The study included 122 patients (122 eyes) with mean age of 73.4±6.

[Three-year follow-up study of clinical effectiveness of antiangiogenic therapy for neovascular age-related macular degeneration].

Purpose: The study analyzes long-term (three years) clinical effectiveness of anti-VEGF treatment of neovascular age-related macular degeneration (nAMD) and attempts to identify the most clinically significant associations between the functional and structural parameters.

Material And Methods: The study included 122 patients (122 eyes) diagnosed with nAMD, mean age -73.4±6.

[New findings on pathogenetic mechanisms in the development of age-related macular degeneration].

Age-related macular degeneration (AMD) is a complex multifactorial disease that occurs due to disfunction and degeneration of retinal pigment epithelium (RPE) and choriocapillaris, as well as death of photoreceptors. The exact pathogenetic mechanism remains uncertain. The aging process is the main and the clearest risk factor of AMD.

[Anti-VEGF therapy for age-related macular degeneration].

Purpose: To evaluate the clinical effectiveness of aflibercept in treatment of patients with neovascular age-related macular degeneration (nAMD).

Material And Methods: The first group included 156 treatment-naive nAMD patients (156 eyes). The second group consisted of 29 patients (38 eyes) with nAMD who had previously received at least 3 loading injections of 0.

[Anti-VEGF therapy for diabetic macular edema. From theory to clinical practice].

Purpose: To evaluate clinical effectiveness of aflibercept therapy for patients with diabetic macular edema (DME) - both naïve to the drug and unresponsive to previous anti-VEGF treatment.

Material And Methods: The study included 127 patients (127 eyes) divided into two groups. The first group consisted of 100 primary DME patients (100 eyes) with mean age of 68.

Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome.

Introduction: This article presents the results of an international, multicenter, randomized, double-masked, placebo-controlled clinical study of Visomitin (Mitotech LLC, Moscow, Russian Federation) eye drops in patients with dry eye syndrome (DES). Visomitin is the first registered (in Russia) drug with a mitochondria-targeted antioxidant (SkQ1) as the active ingredient.

Methods: In this multicenter (10 sites) study of 240 subjects with DES, study drug (Visomitin or placebo) was self-administered three times daily (TID) for 6 weeks, followed by a 6-week follow-up period.

[Ultrasound biomicroscopy findings in the area of previous surgical intervention in refractory glaucoma patients under topical ocular hypotensive therapy].

Aim: to evaluate the effectiveness of different classes of topical hypotensive medications in refractory primary open-angle glaucoma (POAG), judging from structural changes in artificial pathways for intraocular fluid (IOF) visualized with ultrasound biomicroscopy (UBM).

Material And Methods: UBM analysis was performed in 104 eyes of 102 patients, mean age 68.4 ± 0.

[Clinical efficacy of dexamethasone intravitreal implant (Ozurdex) in patients with retinal vein occlusions].

Two cases of dexamethasone intravitreal implant (Ozurdex) use are reported. The drug promotes resolution of macular edema and ensures a long-term improvement of visual acuity. The latter may depend on such factors as the duration of the disease and localization of the occlusion.

[Perinatal risk factors of congenital glaucoma].

The aim is to estimate extragenital diseases, course of pregnancy and delivery in mothers of children with congenital glaucoma and to study somatic and neurological status of these children. Extragenital comorbidity was found in 76.3% of studied women.

[Computer visual syndrome and occupational ophthalmopathy in PC operators].

Information technologies development resulted in occupational ophthalmopathy in PC users. The article covers criteria to define the risk group for prevention and rehabilitation measures.

[Prematurely aging OXYS rats as an animal model of senile cataract in human].

Cataracts remain the major cause of blindness and acuity of vision deterioration in the elderly. To date there are no effective methods of preventive measures of this disease and surgical removal of cataract-damaged lenses remains the only way to restore vision. To explore cataract pathogenesis and development methods of its prophylaxis are necessary fundamental investigation, which is impossible without biological models.