Synthesis of Blue Emissive Quaternary 9,9-Disubstituted -Methyl-7-azaindole-Appended (Phenylethynyl)-fluorene Derivatives.

A highly functionalized 9,9-disubstituted (phenylethynyl)-fluorene-appended -methyl-7-azaindole derivatives has been synthesized from various fluorene propargylic alcohols and substituted-7-azaindoles using BFOEt as a catalyst. The scope of the reaction was demonstrated by selecting a range of fluorene propargylic alcohols and substituting 7-azaindoles. A plausible reaction mechanism for forming title compounds via propargylic carbocation is postulated.

Synthesis, Characterization, Computational Studies, Molecular Docking, and Anticancer Activity of Dihydropyrano[3,2-]chromene and 2-Aminobenzochromene Derivatives.

2-Aminobenzochromenes and dihydropyranochromenes represent a unique class of biologically active compounds. Recent organic syntheses focus on the development of environmentally benign synthetic protocols, and as a part of this concept, we have taken a considerable interest in the synthesis of this class of biologically active compounds using an environment-friendly, reusable heterogeneous Amberlite IRA 400-Cl resin catalyst. This work further aims to highlight the importance and advantages of these compounds and to compare the experimental data obtained with those of the theoretical calculations made using the density functional theory (DFT) method.

Biological evaluation of polycyclic chalcone based acrylamides in human MCF-7 and HeLa cancer cell lines.

Breast and cervical cancer account for the majority of cancer-narrated fatalities among women worldwide, necessitating the development of novel, effective therapeutic ways to combat the disease. In this study, we synthesized 6-methoxy naphthalene and anthracene-based acrylamide chalcone (NBA and ABA) and evaluated its activity for cell multiplication inhibition against two cancer cell lines from humans such as MCF-7 (Human Breast) and HeLa (Cervical) by MTT assay. Physiochemical characterization, such as FT-IR and NMR analyses, validated the synthesized NBA and ABA.

Facile Multicomponent Synthesis, Computational, and Docking Studies of Spiroindoloquinazoline Compounds.

Synthesis of spiroindoloquinazolines via one-pot three-component condensation reactions of tryptanthrin, malononitrile or ethylcyanoacetate, and nucleophiles was carried out in MeOH using triethylamine as the base catalyst under reflux conditions. This method has the advantages of short reaction time, excellent yields, and an easy work-up procedure. The structural properties of the compound {2-amino-6-methyl-spiro-[12]Indolo(2,1-)quinazoline-12-one]12',4-pyrano(2,3-)pyrazole]-3-carbonitrile} and the obtained crystal were analyzed by the DFT theoretical calculation method, using the B3LYP 6-311G(d,p) basis set and were found to be in agreement with the experimental results.