Anticonvulsant activity and toxicity evaluation of Cu(II) and Zn(II) metal complexes derived from triazole-quinoline ligands.

A novel Cu(II) and Zn(II) complexes of triazolo-quinoline derivatives were synthesized by in situ method and were characterized by the spectro-analytical methods and their pharmacological properties were evaluated. The compound C3 has exhibited promising anticonvulsant activity towards the electroshock induced seizures in Wistar rats and possesses low toxicity, providing a high safety profile.

Synthesis and spectroscopy of Co(II), Ni(II), Cu(II) and Zn(II) complexes derived from 3,5-disubstituted-1H-pyrazole derivative: a special emphasis on DNA binding and cleavage studies.

A series of novel Co(II), Ni(II), Cu(II) and Zn(II) complexes of 1H-pyrazole-3,5-dicarboxylic(2'-hydroxy-3'-hydrazinequinoxaline) has been prepared and characterized by the spectral and analytical techniques. Cu(II) ion reacts with the ligand LH(3) and forms the complex in one compartment of the ligand whereas, the other compartment remains free. In Co(II), Ni(II) and Zn(II) complexes both compartments of LH(3) are involved in the coordination.

Synthesis, structure, electrochemistry and spectral characterization of (D-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich ascites carcinoma in Swiss albino mice.

The novel glycosyl saccharide derivative, (D-glucopyranose)-4-phenylthiosemicarbazide (LH) and its complexes, with cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized, characterised and tested for cytotoxic effects. The copper complex, [CuLCl] inhibited Ehrlich Ascites Carcinoma (EAC) induced cancer cell lines in Swiss albino mice at LC50=1.94 x 10(-8) (LC50=2.