Publications by authors named "Gursimran Singh Kochhar"
Disproportionately Increasing Incidence of Inflammatory Bowel Disease in Females and the Elderly: An Update Analysis from the Global Burden of Disease Study 2021.
Am J Gastroenterol
October 2024
Objective: To update the global burden of Inflammatory Bowel Disease (IBD) using data from the Global Burden of Disease (GBD) 2021.
Methods: Data from GBD 2021 were analyzed to assess the IBD burden.
Results: In 2021, there were 375,140 new cases and 3.
Background And Aims: Inflammatory Bowel Disease (IBD) represents a significant health threat worldwide. However, there are deficiencies in large-scale epidemiological research focusing on these issues, especially among young women. We aim to examine the trend of IBD in young females globally.
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- * A thorough diagnostic process, including clinical and imaging assessments, is crucial for effective treatment, which varies for simple and complex fistulas, often including antibiotics and immunomodulators.
- * For hard-to-treat cases, advanced therapies like anti-tumor necrosis factors and new treatments such as stem cell therapy are being explored, but many patients still need surgery.
Article Synopsis
- Inflammatory bowel disease (IBD) is increasingly affecting the elderly, with about 10% of cases now occurring in patients over 65, and this demographic shows greater vulnerability to complications compared to younger patients.
- A study tracked trends in elderly-onset IBD over a decade, revealing that 13% of all IBD cases are now in older adults, with a rise in incidence among males but a decline in females, particularly notable in the Western Pacific region.
- Despite a decreasing trend in mortality and disability-adjusted life years (DALYs), the highest burden of elderly-onset IBD is concentrated in America and high sociodemographic index (SDI) countries, underscoring the need for improved public health
Role of hyperbaric oxygen therapy in patients with inflammatory bowel disease.
Curr Opin Gastroenterol
July 2023
Purpose Of Review: Hypoxia is a known contributor to inflammation in inflammatory bowel diseases (IBD), and a growing interest has emerged in pharmacologically targeting hypoxia response pathways to treat IBD. The most basic form of treatment for hypoxia is delivering higher amounts of oxygen to the intestinal mucosa. In this review, we summarize the evidence in support of hyperbaric oxygen therapy (HBOT), a mechanism to deliver high amounts of oxygen to tissue, for treating IBD.
View Article and Find Full Text PDFThe tip of the "J" of the ileal pouch is the vulnerable location for leak after restorative proctocolectomy, which has normally been treated with surgery. We aimed to describe a novel endoscopic method to treat the same. A cohort of 12 consecutive patients with a leak at the tip of the "J" was identified in our prospectively maintained Pouch Registry.
View Article and Find Full Text PDFCeliac disease is a multisystem autoimmune disorder that can cause symptoms involving the gastrointestinal tract and other organ systems such as the skin and bones. This paper reviews the pathogenesis, diagnosis, and management of celiac disease and associated diseases.
View Article and Find Full Text PDFBackground And Aim: Gastric varices are associated with high mortality. There have been conflicting reports on whether endoscopic treatment with cyanoacrylate or the placement of a transjugular intrahepatic portosystemic shunt (TIPS) is more effective in the treatment of gastric varices. We compared the outcomes of patients treated with cyanoacrylate glue or TIPS for the management of acute gastric variceal bleeding.
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