Publications by authors named "Gursimran Dhamrait"

Article Synopsis
  • The study analyzed interpregnancy intervals (IPIs) and their impact on adverse outcomes in twin pregnancies, covering nearly 10,000 cases in Western Australia from 1980 to 2015.
  • Results indicated that short IPIs (less than 6 months) increased the risk of early preterm birth and low birth weight, while long IPIs (60 months or more) were also linked to higher risks of preterm birth and low birth weight.
  • The strongest negative associations were found with long IPIs, suggesting that both short and exceedingly long IPIs could lead to adverse birth outcomes in twin pregnancies.
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Outdoor play in the home yard is an important source of physical activity for many preschoolers. This study investigated if home yard size and vegetation are related to preschooler outdoor play time. High-resolution remotely sensed data were used to distinguish between types of vegetation coverage in the home yard.

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Background: Maternal exposure to air pollution during pregnancy is associated with adverse birth outcomes, although less is known for wildfire smoke. This systematic review evaluated the association between maternal exposure to wildfire smoke during pregnancy and the risk of perinatal, obstetric, and early childhood health outcomes.

Methods: We searched CINAHL Complete, Ovid/EMBASE, Ovid/MEDLINE, ProQuest, PubMed, Scopus, Web of Science, and Google Scholar to identify relevant epidemiological observational studies indexed through September 2023.

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Child obesity is a serious public health challenge affected by both individual choice and societal and environmental factors. The main modifiable risk factors for child obesity are unhealthy eating and low levels of physical activity, both influenced by aspects of the built environment. Coordinated government policy across jurisdictions, developed using strong research evidence, can enable built environments that better support healthy lifestyles.

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Objective: This study aimed to systematically review the literature on the associations between birth spacing and developmental outcomes in early childhood (3-10 years of age). Studies examining the associations between interpregnancy intervals and child development outcomes during and beyond the perinatal period have not been systematically reviewed.

Methods: We searched Ovid/MEDLINE, Global Health, PsycINFO, EMBASE, CINAHL Plus, Educational Source, Research Starters, ERIC, Scopus, PubMed, Social Science Research Network database, and ProQuest's Social Sciences Databases for relevant articles published between 1 January 1989 and 25 June 2021.

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Article Synopsis
  • The BEACHES study aims to explore the impact of built environments on childhood obesity and physical inactivity, both major risk factors for non-communicable diseases (NCDs) in children in Wales and Australia.
  • It utilizes data from five established cohorts to analyze how various environmental factors influence children's body mass index, physical activity, and dietary habits.
  • The research has obtained necessary ethical approvals and aims to share its findings with a wide range of stakeholders, including parents, schools, and government bodies, to inform policy and promote healthier environments for children.
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Background: This study investigated whether the timing of birth of the younger siblings was associated with the risk of the older siblings' developmental vulnerability in early childhood.

Methods: Linkage of population-level birth registration, hospital, and perinatal datasets to Australian Early Development Census (AEDC) records (2009-2015), enabled follow-up of a cohort of 32,324 Western Australia born singletons. Children with scores <10th percentile on an individual AEDC domain (Physical Health and Wellbeing; Social Competence; Emotional Maturity; Language and Cognitive Skills (school-based); and Communication Skills and General Knowledge) were classified as developmentally vulnerable.

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Background: Prevalence and exposures of adverse birth outcomes is well studied in low-and-middle-income countries but not well-established for the Pacific Island region. Our study mapped the available evidence on low birth weight (LBW), preterm birth, and small for gestational age (SGA)'s prevalence and their corresponding risks in the region.

Methods: We followed the five-staged Arksey and O'Malley's framework with clinicians' consultation in the region.

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The study aimed to investigate the association between interpregnancy interval (IPI) and parent-reported oppositional defiant disorder (ODD) in offspring at 7 and 10 years of age. We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC), an ongoing population-based longitudinal study based in Bristol, United Kingdom (UK). Data included in the analysis consisted of more than 3200 mothers and their singleton children.

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Studies have reported a dose-dependent relationship between gestational age and poorer school readiness. The study objective was to quantify the risk of developmental vulnerability for children at school entry, associated with gestational age at birth and to understand the impact of sociodemographic and other modifiable risk factors on these relationships. Linkage of population-level birth registration, hospital, and perinatal datasets to the Australian Early Development Census (AEDC), enabled follow-up of a cohort of 64,810 singleton children, from birth to school entry in either 2009, 2012, or 2015.

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Objective: To investigate the associations between interpregnancy intervals (IPIs) and developmental vulnerability in children's first year of full-time school (age 5).

Design: Retrospective cohort study using logistic regression. ORs were estimated for associations with IPIs with adjustment for child, parent and community sociodemographic variables.

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Objective: To investigate the prevalence of, and associations between, prenatal and perinatal risk factors and developmental vulnerability in twins at age 5.

Design: Retrospective cohort study using bivariate and multivariable logistic regression.

Setting: Western Australia (WA), 2002-2015.

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In previous preclinical studies, low (non-burning) doses of UV radiation (UVR) limited weight gain and metabolic dysfunction in mice fed with a high-fat diet. Here, we explored the effects of low-dose UVR on physical activity and food intake and mechanistic pathways in interscapular brown adipose tissue (iBAT). Young adult C57Bl/6J male mice, housed as individuals, were fed a high-fat diet and exposed to low-dose UVR (sub-oedemal, 1 kJ/m2 UVB, twice-a-week) or 'mock' treatment, with or without running wheel access (2 h, for 'moderate' physical activity) immediately after phototherapy.

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Article Synopsis
  • The study investigates how low-dose ultraviolet radiation (UVR) impacts metabolic health and obesity, showing that regular UVR exposure reduces weight gain and diabetes symptoms in mice on a high-fat diet through mechanisms involving nitric oxide release from the skin.
  • Researchers used a special type of mouse that helps track certain proteins (UCP-1) to monitor the effects of UVR on weight gain and fat metabolism, finding that UVR exposure improved glucose tolerance and reduced fat accumulation in the liver.
  • While UVR significantly increased UCP-1 expression in mice on a low-fat diet, its effects were not seen in those on a high-fat diet, indicating that the metabolic benefits of UVR may depend on
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The best management of vitamin D deficiency, defined as a 25-hydroxyvitamin D [(25(OH)D] level <50 nM, is unclear. Intramuscular (IM) injection of a large bolus of vitamin D (≥100 000 IU) is used, but its safety is uncertain. In 10 adults given an IM injection of 600 000IU vitamin D3, we measured at baseline and at 1, 2, 3, and 4 weeks postinjection the serum levels of vitamin D3, 25(OH)D3, 25(OH)D2, total 25(OH)D, 3-epi-25(OH)D3, and 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] using a standardized LC with tandem MS (MS/MS) assay; serum levels of 25(OH)D using the Abbott ARCHITECT i2000 immunoassay; and markers of bone metabolism.

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