The challenge of staying in shape: nuclear size matters.

Cellular organelles have unique morphology and the organelle size to cell size ratio is regulated. Nucleus is one of the most prominent, usually round in shape, organelle of a eukaryotic cell that occupies 8-10% of cellular volume. The shape and size of nucleus is known to undergo remodeling during processes such as cell growth, division and certain stresses.

Nucleolar size regulates nuclear envelope shape in .

Nuclear shape and size are cell-type specific. Change in nuclear shape is seen during cell division, development and pathology. The nucleus of is spherical in interphase and becomes dumbbell shaped during mitotic division to facilitate the transfer of one nucleus to the daughter cell.

Predicting subcellular localization of proteins using protein-protein interaction data.

The knowledge of subcellular localization of proteins can provide useful clues about their functions. The conventional methods to determine the subcellular localization are unable to keep pace with the rate at which the new data is being generated. Thus, though sequence information is available, the localization and function of a number of proteins remains unknown.