[Diagnostic capabilities of sound-breathing test in assessment of pulmonary ventilation function in children and adults (retrospective review and prospect)].

Objective: To develop and try out a convenient and accessible for use technology for testing the pulmonary function in children and adults, including in patients with chronic bronchopulmonary pathology.

Material And Methods: The article presents the results of Lazarev sound-breathing test (LST) in different cohorts of children and adults, including pregnant women and children suffering from chronic bronchopulmonary diseases, in particular cystic fibrosis.

Results: A direct dependence of the LST indicators' level from the age of children and adolescents has been obtained.

Effect of Platform Type on Clinical Efficacy of SARS-CoV-2 Vaccines in Prime Vaccination Settings: A Systematic Review and Meta-Regression of Randomized Controlled Trials.

This systematic review investigated the association between platform type and the clinical efficacy of SARS-CoV-2 vaccines using the meta-regression of randomized controlled trials to compare the rates of the first appearance of symptomatic COVID-19 on the platforms. The trial search was conducted using PubMed, ClinicalTrials.gov, and the EU Clinical Trials Register.

Tuning humidity sensing properties grafting fluorine and nitrogen-containing species on single-walled carbon nanotubes.

The effect of humidity on the electrical conductivity of single-walled carbon nanotube (SWCNT) films depends on both the conductivity of individual nanotubes and the electrical contacts between them. Here, we study these factors by comparing the sensor response of nanotubes with fluorine- and nitrogen-containing groups attached to the sidewalls. Experiments carried out in a wide range of relative humidity (RH) at room and elevated temperatures showed that the conductivity of non-functionalized SWCNTs and contacts between them decreases upon the adsorption of water molecules.

Effect of Titanium and Molybdenum Cover on the Surface Restructuration of Diamond Single Crystal during Annealing.

Diamond is an important material for electrical and electronic devices. Because the diamond is in contact with the metal in these applications, it becomes necessary to study the metal-diamond interaction and the structure of the interface, in particular, at elevated temperatures. In this work, we study the interaction of the (100) and (111) surfaces of a synthetic diamond single crystal with spattered titanium and molybdenum films.

[Time-restricted eating as a novel strategy for treatment of obesity and it's comorbid conditions].

The article provides a review of the current literature about time-restricted eating (TRE) as a new tool for the treatment of obesity and comorbid conditions. The search for new nutritional strategies in obesity, one of which is TRE, is due to the weak adherence of patients to hypocaloric diets in the long term, as well as the available data on the importance of -desynchronization of food intake with natural circadian rhythms in the development and progression of obesity and cardio--metabolic complications. The article describes the main mechanisms that regulate the circadian rhythms of food intake and nutrient absorption, substantiates the importance of adhering to a physiological diet for maintaining metabolic health.

Efficacy and safety of iGlarLixi versus IDegAsp: Results of a systematic literature review and indirect treatment comparison.

Aim: To assess the efficacy and safety of iGlarLixi, a fixed-ratio combination of basal insulin glargine 100 U/mL and lixisenatide (glucagon-like peptide-1 receptor agonist) versus IDegAsp, a co-formulation of basal insulin degludec 100 U/mL with rapid-acting insulin aspart.

Materials And Methods: A systematic literature search of randomized controlled trials (RCTs) was performed. Outcomes from eligible RCTs were compared by an indirect treatment comparison using a Bayesian framework.

Enhancement of Volumetric Capacitance of Binder-Free Single-Walled Carbon Nanotube Film via Fluorination.

Robust electrode materials without the addition of binders allow increasing efficiency of electrical storage devices. We demonstrate the fabrication of binder-free electrodes from modified single-walled carbon nanotubes (SWCNTs) for electrochemical double-layer capacitors (EDLCs). Modification of SWCNTs included a sonication in 1,2-dichlorobenzene and/or fluorination with gaseous BrF at room temperature.

[Alexithymia and its relation with eating disorders and obesity].

This manuscript provides a review of current literature on the relationship between overweight and alexithymia as a psychological factor associated with obesity, as well as the role of alexithymia in the development of various abnormalities and eating disorders (ED). Obesity is a multifactorial disease, and lifestyle characteristics are the most important pathogenetic links on its development, as well as a complex of genetic, epigenetic, biological and psychological factors that cause accumulation of excessive fat and prevent effective reduction and retention of body weight. One possible reason for the increased prevalence of obesity in adults is poor emotional management, which can affect healthy eating behavior and lifestyle.

Light-Induced Sulfur Transport inside Single-Walled Carbon Nanotubes.

Filling of single-walled carbon nanotubes (SWCNTs) and extraction of the encapsulated species from their cavities are perspective treatments for tuning the functional properties of SWCNT-based materials. Here, we have investigated sulfur-modified SWCNTs synthesized by the ampoule method. The morphology and chemical states of carbon and sulfur were analyzed by transmission electron microscopy, Raman scattering, thermogravimetric analysis, X-ray photoelectron and near-edge X-ray absorption fine structure spectroscopies.

[Prevention of paracolostomic hernia].

Aim: To improve the prevention of paracolostomic hernias.

Material And Methods: We studied the prevention of paracolostomic hernia using mesh allograft. The study involved 73 patients with low-ampullary rectal cancer.

New mutations in the human p53 gene--a regulator of the cell cycle and carcinogenesis.

Mutations in the tumor suppressor gene p53 often lead to disarrangement of the cell cycle and of genetic integrity control of cells that may contribute to tumor development. We studied p53 gene mutations in 26 primary tumors of colorectal cancer patients. Mutations in p53 were found in 17 tumors (65.

Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients.

Antibodies to cancer antigens can often be detected in the sera of patients, although the mechanism of the underlying humoral immune response is poorly understood. Using immunoscreening of tumor-derived cDNA expression libraries (SEREX), we identified human histone deacetylase 3 (HDAC3) as serologically defined antigen in colon cancer. Closely related HDAC1 and HDAC2 do not elicit humoral response in colon cancer patients.

Randomized study of antibodies to IFN-gamma and TNF-alpha in secondary progressive multiple sclerosis.

Studies of cytokines in multiple sclerosis (MS) have shown that immune mechanisms connected with disturbance of the synthesis of cytokines probably play critical roles in the initiation and prolongation of MS. In a double-blind, placebo-controlled trial, 45 patients with active secondary progressive MS were randomized to three groups of 15 patients, each receiving a short course of antibodies to IFN-gamma, to tumor necrosis factor (TNF)-alpha, or a placebo. After 12 months with analysis of disability (Expanded Disability Status Scale scores), accompanied by interval determinations of lymphocyte subpopulations, cytokine production levels, MRI, and evoked potentials, it was found that only patients who received antibodies to IFN-gamma showed statistically significant improvement compared to the placebo group--a significant increase in the number of patients without confirmed disability progression.

[Kapromed - antibacterial suture material].

The paper gives data on the composition and strength characteristics and experimental and clinical findings of resolving antimicrobial suture materials, such as Capromed-type one, based on the modified caproic fiber coated by the biocompatible polymer PPB-1 which contains antimicrobial drugs. Capromed threads are demonstrated to have high strength characteristics and resolve in the body within 8-9 months. Coating the modified caproic fibers with the biocompatible copolymer imparts them pseudomonfilament characteristics and prevents the penetration of cellular elements to the thickness of threads.

[The role of the liver in regulating the blood iron biorhythms of rabbits with acute alcoholic intoxication].

Experiments with male California rabbits were carried out different intervals of acute alcohol intoxication induced by intragastric administration of 40% ethanol solution in a dose of 10 ml/kg to examine daily changes of concentration of iron, alpha-tocopherol and lipid peroxidation products in the blood plasma from vena portal and vena hepatis. Acute alcohol intoxication was demonstrated to be accompanied by inversion in temporal organization of lipid peroxidation products, sideremia and alpha-tocopherol levels in the blood of vena hepatis. The invariability of the circadian rhythms of iron, alpha-tocopherol and lipid peroxidation products levels in vena portal blood a considered to prove participation of the liver in regulation of iron metabolism temporal organization in California rabbits with acute alcohol intoxication.

[Morphofunctional adjustments in the microvasculature of the conjunctiva of the human eye at different stages of the postnatal period of ontogenesis].

By means of the biomicroscopy method under vital conditions, conjunctival microvessels in the eyeball have been investigated in 240 healthy boys 7-17 years of age at the state of rest and at the antiorthostatic action. The rearrangement of the conjunctival microcirculatory bed of the eyeball completes on the whole by 13-14 years of age and is characterized by transition from diffuse to a more refulate structure (the number of the main magistrals lessens, they become larger, the number of capillaries functioning simultaneously decreases, the role of the shunting blood stream becomes more important). With this process in ontogenesis, certain changes in reactivity of microvessels are connected.