Plasma homocysteine in obese, overweight and normal weight hypertensives and normotensives.

Aim: The aim of the present study was to assess the interrelationship of obesity with plasma homocysteine levels as well as vitamin B12 and folic acid levels in hypertensive and normotensive subjects.

Methods: Sixty-five hypertensive and sixty-five normotensive patients were studied. Plasma homocysteine, vitamin B12 and folic acid, lipid parameters, blood pressure, pulse pressure levels, body mass index were estimated in all the subjects.

Interrelationships of Factor VII activity and plasma leptin with insulin resistance in coronary heart disease.

Objective: An increase of FVII activity (FVIIc) has been proposed to be an independent cardiovascular risk factor. Whether FVII is associated with insulin resistance in coronary heart disease (CHD) is still unknown. We tested the hypothesis that plasma FVII activity and leptin are associated with insulin resistance independently.

Plasma leptin in insulin-resistant and insulin-nonresistant coronary artery disease and its association with cardio-metabolic risk factors among Asian Indians.

Background: The relationship between plasma leptin and insulin resistance among coronary artery disease (CAD) subjects remains poorly understood. We determined plasma leptin levels in insulin-resistant and insulin-nonresistant CAD patients. We also examined the association of plasma leptin with several cardiometabolic risk factors in all of the study group subjects from an Asian Indian population.

The endothelial leukocyte adhesion molecule. Role in coronary artery disease.

Objectives: It is hypothesized that adhesion molecules could be an early predictor of coronary artery disease. The endothelial leucocyte adhesion molecule (ELAM) is expressed on activated endothelial cells only and it has been found to exist in a soluble form. This soluble form (sELAM) may be an important marker for endothelial cell damage.

Role of endothelin-1 in genesis of coronary artery disease.

Background: The endothelial cells produce the most potent vasoconstrictor known as endothelin-1. Elevated plasma levels of endothelin have been associated with coronary artery disease, essential hypertension and heart failure. The aims of the present study were, to compare the plasma endothelin-1 levels in coronary artery disease patients and healthy controls, to confirm endothelin-1 as surrogate marker for coronary artery disease and to compare the presence of endothelin-1 like immunoreactivity in aortic and internal mammary artery specimens obtained during coronary artery bypass graft surgery.