Publications by authors named "Gurashvili T"

Unlabelled: This research article elucidates the pivotal role of radiopharmacy in the contemporary landscape, underscoring its potential therapeutic efficacy in addressing symptoms associated with aged-related neurocognitive processes. Clinical trials, characterized by the judicious application of modest radiation doses, exemplified by low-dose radon, have yielded affirmative outcomes in the amelioration of aged, related symptoms.

Material And Methods: The study was conducted on an animal model.

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In order to explore the distant results of exposition of little doses of lead, for the objective of the experiment model we have selected 32 mongral rats, of different age, but aged of both sex. Experimental animals were divided in two groups. During first two month from the beginning of the experiment, together with permissible food, animals were given the water, in which was open Pb(NO3)2 - to first group 1.

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Transcranial direct current stimulation (tDCS) is a promising and well-tolerated method of non-invasive brain stimulation, by which cortical excitability can be modulated. However, the effects of tDCS on the developing brain are still unknown, and knowledge about its tolerability in children and adolescents is still lacking. Safety and tolerability of tDCS was assessed in children and adolescents by self-reports and spectral characteristics of electroencephalogram (EEG) recordings.

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The role of the posterior parahippocampal area of the brain in spatial types of memory in conditions of one-trial visual perception of the positions of objects was studied by training eight cats to remember the spatial positions of either two different objects covering two of three feeders placed on a test tray (tests for the "object-place" association) or the positions of two of three feeders (tests for place). Each trial used new objects and new positions for the two of three feeders. After training, four cats were subjected to electrolytic lesioning of the posterior parahippocampal area, primarily the parahippocampal cortex, parasubiculum, and presubiculum; the remaining four cats underwent all the surgical procedures except electrocoagulation of nervous tissue; this was the sham-operated control group.

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To determine the contribution of the posterior parahippocampal region to spatial form of one-trial memory in cats, we trained 8 cats to remember the spatial positions of either two different trial-unique objects overlying two of three feeders in a feeder test tray (object-place trials) or simply two of the three feeders (place trials). Four cats then received electrolytic lesions restricted to the posterior parahippocampal region (experimental group) including mainly parahippocampal cortex, parasubiculum and presubiculum. Four other cats comprised sham-operated control group.

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Memory for visual recognition in primates is at least partially mediated by the peripheral and entorhinal (i.e., rhinal) areas of the cerebral cortex.

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Visual recognition memory in primates is mediated at least in part by the perirhinal and entorhinal (i.e., rhinal) cortices.

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The ability of normal cats to perform delayed matching- and nonmatching-to-sample with trial-unique stimuli was investigated both in a modified Wisconsin General Testing Apparatus requiring manipulatory responses and in a Nencki-type testing room requiring locomotor responses. Cats trained in the WGTA learned the two tasks at about the same rate, on average, as that reported for monkeys. However, unlike monkeys, whose strong preference for novelty facilitates their learning of the nonmatching rule and retards their learning of the matching rule, the cats learned the two different rules at about the same rate, suggesting that cats do not share the monkey's strong preference for novelty.

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