Publications by authors named "Guqiao Nie"
Understanding the Complexity of Hypertension with Sarcopenia by Scientometric Analysis.
J Multidiscip Healthc
December 2024
Objective: The scientometric analysis was aim to focus on recent studies and clarify new research directions on hypertension with sarcopenia. We hope to provide comprehensive insights or actionable recommendations for clinicians or policymakers.
Methods: The Web of Science Core Collection database (WoSCC) from 2004 to 2023 for analysis was used.
Article Synopsis
- * Denosumab is an anti-osteoporotic drug that reduces bone loss and may also improve aspects of sarcopenia, showing promise as a treatment for both conditions.
- * Current research on Denosumab's effectiveness for sarcopenia, particularly in China, is limited, highlighting the need for further studies to better understand its mechanisms and impacts.
Article Synopsis
- * Results indicated that severe OSAS significantly increases the risk of hypertension and that higher TyG-BMI levels correlate with an elevated risk of hypertension, especially in the highest quartile.
- * TyG-BMI was found to mediate 41.3% of the association between OSAS and hypertension, highlighting its importance for evaluating hypertension risk in OSAS patients.
Objective: Employing body composition analysis, this study aims to examine the influencing factors and conduct predictive analysis regarding sarcopenia incidence in the middle-aged and elderly population in China.
Methods: This study recruited inpatients from the General Medicine Department of Tongji Medical College Affiliated Union Hospital, Huazhong University of Science and Technology, as the subjects for a single-center retrospective study. Diagnosis was conducted according to the 2019 criteria from the Asian Working Group for Sarcopenia.
Article Synopsis
- The ZJU index, which measures obesity and insulin resistance through various health indicators, was studied for its correlation with the risk of obstructive sleep apnea syndrome (OSAS).
- In a study with 2,130 participants, results showed that higher ZJU index levels were linked to increased OSAS diagnoses, with an odds ratio of 2.046 for those at the highest levels.
- The study found that the ZJU index offers predictive capability for OSAS risk, with different effectiveness for males and females based on area under the curve (AUC) values, suggesting individuals with higher indexes are at notable risk.
Objectives: Sarcopenia is a known risk factor for non-alcoholic fatty liver disease (NAFLD). Studies evaluating the association between the fat-to-muscle ratio (FMR) and NAFLD are limited. Therefore, the aim of our study was to investigate the association between FMR and NAFLD.
View Article and Find Full Text PDFAssociation of hyperuricemia combined with sarcopenia on ASCVD risk.
BMC Cardiovasc Disord
June 2023
Background: Hyperuricemia and sarcopenia are both strongly linked to an increased risk of atherosclerotic cardiovascular disease (ASCVD), and this study was designed to look into the interactive effects of hyperuricemia on ASCVD risk.
Methods: This study collected information from patients (N = 2647) who underwent health check-ups at the Health Care Building of Wuhan Union Hospital between January 2019 and December 2020. Skeletal muscle mass was measured using bioelectrical impedance methods.
Purpose: Altered body composition and liver enzymes are known to be related to cardiometabolic risk. Our study aimed to evaluate the association between fat-to-muscle ratio (FMR), alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and cardiometabolic risk.
Methods: In total, 1557 participants aged ≥40 years were included.
Background: Currently, both metabolic syndrome and hyperuricaemia have attracted extensive attention in public health. The correlation between uric acid and metabolic syndrome is controversial. Research on the relationship between uric acid and metabolic syndrome in community-dwelling elderly people is relatively lacking.
View Article and Find Full Text PDFObjectives: To investigate the relationship between triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and metabolic syndrome in the elderly population of China, and to determine the best critical value of TG/HDL-C in higher risk of metabolic syndrome in this population.
Design: Cross-sectional study.
Setting: Our study was conducted in a community physical examination centre in Wuhan, China between 1 January 2016 and 31 December 2016.
Teneligliptin prevents doxorubicin-induced inflammation and apoptosis in H9c2 cells.
Arch Biochem Biophys
April 2020
Doxorubicin is a common chemotherapy treatment with numerous negative ramifications of use such as nephropathy and radiation-induced cardiotoxicity. Doxorubicin has been shown to cause overexpression of proinflammatory cytokines including MCP-1 and IL-1β via activation of the NF-κB pathway. Furthermore, apoptosis marked by dysregulation of the Bax/Bcl-2 ratio and oxidative stress and the production of reactive oxygen species (ROS) are also exacerbated by doxorubicin administration.
View Article and Find Full Text PDF