Publications by authors named "Gupta S"

Nursing homes (NHs) have long struggled with nurse shortages, leading to a greater reliance on agency nurses. The purpose of this study was to examine the impact of NH ownership on agency nurse utilization. Data were derived from multiple sources, including the Payroll-Based Journal and NH Five-Star Facility Quality Reporting System (n: 38,550 years: 2020-2022).

View Article and Find Full Text PDF

The NLRP3 inflammasome is a multiprotein complex that upon activation by the innate immune system drives a broad inflammatory response. The primary initial mediators of this response are pro-IL-1β and pro-IL-18, both of which are in an inactive form. Formation and activation of the NLRP3 inflammasome activates caspase-1, which cleaves pro-IL-1β and pro-IL-18 and triggers the formation of gasdermin D pores.

View Article and Find Full Text PDF

Background: This study aimed to objectively assess the laparotomy pads to potential hemorrhage sites proximity in pelvic fracture patients who underwent post-pre peritoneal packing (PPP) CT scans with packs in situ.

Methods: The CT scans of 19 patients were assessed to measure the distance between laparotomy pads and predetermined pelvic anatomical landmarks.

Results: A total of 38 measurements showed that the median pack-to-point distance for the sacroiliac joint was 2.

View Article and Find Full Text PDF

There is growing demand for the utilization of first-row transition metal complexes in light-driven processes instead of their conventional noble metal counterparts due to the greater sustainability of first-row transition metal complexes. However, their major drawback is the ultrafast lifetime of the electronic excited states of these first-row transition metal complexes, particularly those of d square-planar systems such as Ni(II) complexes, wherein low-lying metal-centered (MC) states provide the deactivation pathway. To increase the excited-state lifetime and broaden their applications, it is important to develop sterically bulky, strong field ligands with low-lying π* orbitals and a highly σ-donating nature to augment the energy of MC states.

View Article and Find Full Text PDF
Article Synopsis
  • Osseous tumors of the foot and ankle are rare, representing only 3% of bone neoplasms, and distinguishing between benign and malignant types can be challenging, leading to misdiagnosis and litigation risks.
  • A study analyzed 288 cases over 10 years, finding most new referrals were benign tumors (52.4%), with notable examples being osteoid osteoma and osteosarcoma, stressing the importance of early and accurate diagnosis as symptoms often persisted for an average of 5 months before referral.
  • The conclusion emphasizes the need for improved understanding and recommended management protocols to help reduce misdiagnoses and improve treatment outcomes for these conditions.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates porokeratosis localized to the penis and scrotum, analyzing data from patients diagnosed between 2000 and 2022.
  • Nine patients were included, with a median age of 51, and most had either penile or scrotal lesions, while one had extensive lesions affecting multiple areas.
  • The findings indicate that clinical diagnosis can be challenging and highlights the importance of histopathological examination, as follow-ups showed no recurrence or malignant transformation in patients after biopsy removal.
View Article and Find Full Text PDF

Polymorphous adenocarcinoma (PAC) of head and neck tumors is a rare salivary gland neoplasm of indolent course. We reported a 63-year-old female who presented as an asymptomatic mass in buccal space. The patient, after metastatic workup, underwent complete excision of the lesion with a negative margin.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the structural and magnetic properties of the GdRhIn compound, revealing a hexagonal crystal structure through X-ray diffraction.
  • It identifies two key magnetic transitions: one from antiferromagnetic to ferromagnetic at 16 K and another from ferromagnetic to paramagnetic at 34 K, confirmed by heat capacity measurements.
  • The compound exhibits a significant magnetocaloric effect, with calculated refrigerant capacities suggesting its potential use in magnetic refrigeration at low temperatures.
View Article and Find Full Text PDF

The landscape of clinical management for metastatic melanoma (MM) and other solid tumors has been modernized by the advent of immune checkpoint inhibitors (ICI), including programmed cell death-1 (PD-1), programmed cell death-ligand 1 (PD-L1), and cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibitors. While these agents demonstrate efficacy in suppressing tumor growth, they also lead to immune-related adverse events (irAEs), resulting in the exacerbation of autoimmune diseases such as rheumatoid arthritis (RA), ulcerative colitis (UC), and Crohn's disease (CD). The immune checkpoint inhibitors offer promising advancements in the treatment of melanoma and other cancers, but they also present significant challenges related to irAEs and autoimmune diseases.

View Article and Find Full Text PDF

Gender-affirming surgery (GAS) is a highly personalized decision for transgender and gender diverse (TGD) individuals. However, the proportion of TGD individuals who desire GAS is unknown. A questionnaire was created after identifying themes surrounding experiences with gender-affirming medical care by community focus groups.

View Article and Find Full Text PDF
Article Synopsis
  • Experimental autoimmune encephalomyelitis (EAE) is used as a model for studying CNS diseases like multiple sclerosis, and this research focuses on improving the production of recombinant human MOG (rhMOG) to study EAE in mice.
  • The new protocol utilizes SHuffle E. coli cells to produce high-yield, soluble rhMOG, overcoming the challenges of using bacterial cells which often lead to insolubility and ineffective protein folding.
  • The effective production of rhMOG not only allows for B cell-dependent EAE induction in wild-type mice but also sets the stage for further research into the role of MOG in CNS demyelinating diseases.
View Article and Find Full Text PDF

Red fluorescent protein (RFP)-based fluorescent probes that can selectively interact with specific nucleic acids are of great importance for therapeutic and bioimaging applications. Herein, we have reported the synthesis of RFP chromophores for selective recognition of G-quadruplex nucleic acids in vitro and ex vivo. We identified as a fluorescent turn-on probe that binds to the dimeric NG16 parallel quadruplex with superior selectivity and sensitivity over various parallel, antiparallel, and hybrid topologies.

View Article and Find Full Text PDF
Article Synopsis
  • Understanding the gut microbiome is crucial for sustainable aquaculture as it affects fish digestion, metabolism, health, and growth.
  • The Salmon Microbial Genome Atlas has compiled 211 high-quality bacterial genomes from wild and farmed Atlantic salmon, revealing diverse taxonomic classifications and new species.
  • The study characterized key bacterial populations that can break down dietary fibers and produce beneficial compounds, providing a valuable resource for future research on salmon nutrition and health.
View Article and Find Full Text PDF

Developing a molecular-level understanding of the properties of water is central to numerous scientific and technological applications. However, accurately modeling water through computer simulations has been a significant challenge due to the complex nature of the hydrogen-bonding network that water molecules form under different thermodynamic conditions. This complexity has led to over five decades of research and many modeling attempts.

View Article and Find Full Text PDF

DFT-based calculations were undertaken to, first, fully optimize and study the structural and electrical properties of bare BP nanowire (NW) in its hexagonal wurtzite (WZ) phase. The bare BP NW was found to have an indirect bandgap of 1.362 eV.

View Article and Find Full Text PDF

Recent discoveries have established the pivotal role of IL-9-secreting immune cells in a wide spectrum of inflammatory and autoimmune diseases. However, little is known about how IL-9 contributes to the etiology of inflammatory bone loss in PMO. We observed that IL-9 has a pathological impact on inflammatory bone loss in ovariectomized (Ovx) mice.

View Article and Find Full Text PDF

Intensity-modulated radiation therapy (IMRT) has brought about interest in adaptive radiotherapy (ART) due to its benefit of accurately prescribing doses to tumors and sparing normal critical organs. Critical dosimetric errors and geometrical misses can occur due to anatomical changes during radiotherapy. In the present study, five patients with head and neck malignancies undergoing radiation therapy were assessed for changes in primary gross tumor volume (GTVp), nodal gross tumor volume (GTVn), and clinical target volume-high risk (CTV-HR) using weekly megavoltage-cone beam computed tomography (MV-CBCT) scans.

View Article and Find Full Text PDF

Introduction: Tooth discoloration is a common issue for oral health practitioners. Whitening treatments remove surface and deep stains using either chemicals or over-the-counter products. Due to harmful chemical effects, organic whitening products are increasingly preferred.

View Article and Find Full Text PDF

Introduction: Health care providers caring for youth with physical disabilities encourage them to be as independent as possible, which includes obtaining higher education when feasible. However, little is known about the experiences of higher education students in managing their toileting.

Methods: We performed 1:1 semi-structured interviews with 13 current college students with physical disabilities (4 male, 9 female), of whom six were on a formal bladder and/or bowel management program.

View Article and Find Full Text PDF
Article Synopsis
  • * Cybernetic modeling is a technique that simulates regulatory mechanisms in cellular metabolism, specifically examining how arachidonic acid (AA) and eicosapentaenoic acid (EPA) compete for the cyclooxygenase (COX) enzyme, which affects inflammatory responses.
  • * This study validated a cybernetic model that accurately predicts how AA and EPA levels influence inflammation in macrophages, showcasing a shift from a pro-inflammatory state to an anti-inflammatory state with EPA-supplementation and providing insights into concentrations needed for this transition.
View Article and Find Full Text PDF

Prion disease is a fatal and infectious neurodegenerative disorder caused by the trans-conformation conversion of PRNP/PrP to PRNP/PrP. Accumulated PRNP/PrP-induced ER stress causes chronic unfolded protein response (UPR) activation, which is one of the fundamental steps in prion disease progression. However, the role of various ER-resident proteins in prion-induced ER stress is elusive.

View Article and Find Full Text PDF
Article Synopsis
  • Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is rising in incidence, especially in countries like India, where it has become the second highest in the world.* -
  • The disease is linked to an inappropriate immune response involving various helper T cell subsets and their cytokines, which contribute to gut inflammation and severity.* -
  • The review discusses how different T cell types, including CD8, NKT, and γδT cells, affect IBD outcomes and also explores potential therapeutic options for managing the disease.*
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session4p5gh185d32ueeq4h65d20qdhitij5es): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: A non-numeric value encountered

Filename: controllers/Author.php

Line Number: 219

Backtrace:

File: /var/www/html/application/controllers/Author.php
Line: 219
Function: _error_handler

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: A non-numeric value encountered

Filename: libraries/Pagination.php

Line Number: 413

Backtrace:

File: /var/www/html/application/controllers/Author.php
Line: 274
Function: create_links

File: /var/www/html/index.php
Line: 316
Function: require_once