IGF2BP3 Triggers STAT3 Pathway by Stabilizing SRC RNA in an m6A-Dependent Manner to Promote Lymphatic Metastasis in LUAD.

Lymph node metastasis significantly affects the NSCLC patients' staging, treatment strategy, and prognosis. Studies have shown that IGF2BP3, an oncofetal protein and an m6A reader, overexpresses and correlates to lymph node metastasis and worse overall survival in histopathological studies including NSCLC, but its mechanism needs further study. This study explored IGF2BP3's function and mechanism in LUAD lymphatic metastasis using public databases, a human LUAD tissue microarray, human LUAD cells, and a lymphatic metastasis model in male BALB/c nude mice.

Modeling study of divertor particle flow pattern and in-out plasma density asymmetry due to drifts with SOLPS and BOUT+.

A study of the effects of drifts on the particle flow pattern and in-out divertor plasma density asymmetry for L-mode and H-mode plasmas is carried out for EAST discharges by the edge plasma transport codes SOLPS and BOUT++ . The simulation of L-mode plasmas is done by SOLPS while the simulation of H-mode plasmas is done by BOUT++ . The toroidal magnetic field direction for the simulated discharge is artificially reversed in the codes to study the effects of different drift directions on the divertor particle flow pattern and the in-out asymmetry of divertor plasma density.

Multienzyme Redox System with Cofactor Regeneration for Cyclic Deracemization of Sulfoxides.

Optically pure sulfoxides are noteworthy compounds applied in a wide range of industrial fields; however, the biocatalytic deracemization of racemic sulfoxides is challenging. Herein, a high-enantioselective methionine sulfoxide reductase A (MsrA) was combined with a low-enantioselective styrene monooxygenase (SMO) for the cyclic deracemization of sulfoxides. Enantiopure sulfoxides were obtained in >90 % yield and with >90 % enantiomeric excess (ee) through dynamic "selective reduction and non-selective oxidation" cycles.

[Chronic headache treated with acupuncture, Chinese massage and herbal medicine in Switzerland].

Objective: To observe the therapeutic effect of Chinese medicine on chronic disease in foreign country.

Methods: Forty-two cases of chronic headache were treated with acupuncture, Chinese massage and herbal medicine in Switzerland. The efficacy assessment was performed for the symptom score and the physical and mental improvements by the patients themselves before and after treatment.