Edaravone Improves Motor Dysfunction Following Brachial Plexus Avulsion Injury in Rats.

Brachial plexus root avulsion (BPRA) is often caused by road collisions, leading to total loss of motor function in the upper limb. At present, effective treatment options remain limited. Edaravone (EDA), a substance that eliminates free radicals, exhibits numerous biological properties, including neuroprotective, antioxidant and anti-inflammatory effects.

study on the effect of peucedanol on the activity of cytochrome P450 enzymes.

Context: Peucedanol is a major extract of Thunb. (Apiaceae) roots, which is a commonly used herb in paediatrics. Its interaction with cytochrome P450 enzymes (CYP450s) would lead to adverse effects or even failure of therapy.

Upregulated expression of long non-coding RNA MEG3 serves as a prognostic biomarker in severe pneumonia children and its regulatory mechanism.

Severe pneumonia is a high-mortality disorder in children. The expression and underlying effects of lncRNA maternally expressed 3 (MEG3) were detected. The relationships between MEG3 and other parameters were reported by Pearson correlation.

Clinical significance of miR-181a in patients with neonatal sepsis and its regulatory role in the lipopolysaccharide-induced inflammatory response.

Neonatal sepsis (NS) poses a serious threat to the health of neonates worldwide. The present study aimed to investigate the diagnostic value of microRNA (miR)-181a in patients with NS and the regulatory role of miR-181a in lipopolysaccharide (LPS)-induced inflammation. A total of 102 neonates with NS and 50 neonates without sepsis were enrolled in the present study.

A primary model of THz and far-infrared signal generation and conduction in neuron systems based on the hypothesis of the ordered phase of water molecules on the neuron surface I: signal characteristics.

In this paper, we use the theory of quantum optics and electrodynamics to study the electromagnetic field problem in the nervous system based on the assumption of an ordered arrangement of water molecules on the neuronal surface. Using the Lagrangian of the water molecule-field ion, the dynamic equations for neural signal generation and transmission are derived. Perturbation theory and the numerical method are used to solve the dynamic equations, and the characteristics of high-frequency signals (the dispersion relation, the time domain of the field, the frequency domain waveform, etc.

Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats.

Omeprazole and astragaloside IV (AS-IV) are widely used for the treatment of gastric ulcers in China clinics. This study investigates the effects of AS-IV on the pharmacokinetics of omeprazole in rats. The pharmacokinetics of orally administered omeprazole (2 mg/kg), with or without AS-IV (100 mg/kg/day for 7 days) pretreatment, were investigated in male Sprague-Dawley rats (two groups of six animals each) using LC-MS/MS.

Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model.

BACKGROUND Bile acids (BAs) are signaling molecules that participate in maintaining glucose homeostasis. Acute enteral infusion of BAs potently reduces the glycemic response to glucose, associated with an increase of incretin hormones. However, the effect of long-term supplementation of BAs on glucose metabolism has not been fully investigated.

High-efficiency coaxial relativistic backward wave oscillator.

This paper studies the coaxial relativistic backward wave oscillator (CRBWO) through analytical, numerical, and experimental methods. This new type of device is remarked by its high efficiency of more than 35%, which is predicted by the theoretical calculation and the numerical simulation and validated by experiment. The two primary hindrances preventing CRBWO from achieving the expected high efficiency, the poor coaxiality and the power capacity, are discussed in detail and some advanced methods are developed.

All-solid-state repetitive semiconductor opening switch-based short pulse generator.

The operating characteristics of a semiconductor opening switch (SOS) are determined by its pumping circuit parameters. SOS is still able to cut off the current when pumping current duration falls to the order of tens of nanoseconds and a short pulse forms simultaneously in the output load. An all-solid-state repetitive SOS-based short pulse generator (SPG100) with a three-level magnetic pulse compression unit was successfully constructed.