The Adsorption Behavior of Gas Molecules on Mn/N- and Mn-Doped Graphene.

By using density functional theory (DFT), the adsorption behavior of gas molecules on defective graphene doped with manganese and nitrogen were investigated. The geometric structure, electronic structure, and magnetic properties of two substrates were calculated and the sensing mechanism was also analyzed. The results indicate that the MnSV-GP and MnN-GP have stronger structural stability, in which Mn atoms and their coordination atoms will become the adsorption point for five gas molecules (CHO, CO, NO, SO, and NH), respectively.

The efficacy and safety of fluvoxamine in patients with COVID-19: A systematic review and meta-analysis from randomized controlled trials.

Background: Recently, several randomized controlled trials (RCTs) of fluvoxamine have been successfully conducted for the treatment of patients with coronavirus disease 2019 (COVID-19). This systematic review and meta-analysis was to evaluate the efficacy and safety of fluvoxamine in patients with COVID-19.

Methods: MEDLINE, EMBASE, Cochrane Library and clinicaltrials.

Pallidal versus subthalamic deep brain stimulation for Meige syndrome: A systematic review and meta-analysis.

Background: Globus pallidus internus (GPi) and subthalamic nucleus (STN) are two common deep brain stimulation (DBS) targets. This meta-analysis was to compared the efficacy and safety of these two DBS targets for the treatment of Meige syndrome (MS).

Methods: A systematic search was performed using EMBASE, MEDLINE, the Cochrane Library, and ClinicalTrials.

Ultrasound-guided radiofrequency ablation for the treatment of papillary thyroid carcinoma: a review of the current state and future perspectives.

Papillary thyroid carcinoma (PTC) is a highly prevalent cancer that typically exhibits indolent behavior and is associated with a favorable prognosis. The treatment of choice is surgical intervention; however, this approach carries the risk of complications, including scarring and loss of thyroid function. Although active surveillance can mitigate the risk of PTC overtreatment, the possibility of tumor growth and metastasis can elicit anxiety among patients.

Correction: Catalytic wet peroxide degradation of acrylonitrile wastewater by ordered mesoporous Ag/CeO: synthesis, performance and kinetics.

[This corrects the article DOI: 10.1039/D1RA01258D.].

Correction: Silver/silver halide supported on mesoporous ceria particles and photo-CWPO degradation under visible light for organic compounds in acrylonitrile wastewater.

[This corrects the article DOI: 10.1039/D1RA04465F.].

Multi-Residue Detection of Eight Glucocorticoids by Nano-Au/Fluticasone Propionate Electrochemical Immunosensor.

Based on an indirect competitive method, a novel nano-Au/fluticasone propionate electrochemical immunosensor was successfully fabricated by combining the nanoscale effect, superior conductivity of nano-Au, stable Au-S chemical bond as well as strong interaction between glucocorticoid and the receptor, which was used to simultaneously detect eight kinds of glucocorticoids. The modified immunosensors' electrochemical properties were explored by means of a cyclic voltammetry (CV) method and electrochemical impedance spectroscopy (EIS) measurements. Two factors (glucocorticoid receptor concentration, incubation time) were studied in order to obtain the optimal results.

Targeting EZH2 regulates the biological characteristics of glioma stem cells via the Notch1 pathway.

Glioma is the most common malignant brain tumor, and its behavior is closely related to the presence of glioma stem cells (GSCs). We found that the enhancer of zeste homolog 2 (EZH2) is highly expressed in glioma and that its expression is correlated with the prognosis of glioblastoma multiforme (GBM) in two databases: The Cancer Genome Atlas and the Chinese Glioma Genome Atlas. Additionally, EZH2 is known to regulate the stemness-associated gene expression, proliferation, and invasion ability of GSCs, which may be achieved through the activation of the STAT3 and Notch1 pathways.

Catalytic wet peroxide degradation of acrylonitrile wastewater by ordered mesoporous Ag/CeO: synthesis, performance and kinetics.

Ordered mesoporous Ag/CeO catalysts have been successfully synthesized by a microwave assisted soft template method. The morphology, structure and chemical composition of the catalyst were characterized by XRD, N adsorption-desorption, SEM, EDS, TEM and XPS. The study of catalytic performance and reaction kinetics of organic matter degradation in acrylonitrile wastewater was performed in a catalytic wet peroxide (CWPO) system.

The modulation effect of pi-pi interactions on the electronic and photochromic properties of viologen complexes containing ,'-bis(carboxyethyl)-4,4'-bipyridinium.

Two viologen complexes containing ,'-bis(carboxyethyl)-4,4'-bipyridinium (BCEbpy) were prepared, namely [Zn(HO)]·(BCEbpy)·(-BDC)·3HO (1) and [Co(HO)]·(BCEbpy)·(-BDC)·3HO (2) (-HBDC = 1,4-benzenedicarboxylic acid), and their crystal structures, photochromism, frontier molecular orbitals, Hirshfeld surfaces and 2D fingerprint plots were investigated. The modulation effects of pi-pi interactions were explored on the electronic and photochromic properties of compounds 1 and 2. Due to the existence of photo-response viologen radicals, both complexes 1 and 2 display excellent photo-response properties in the sequence 1 < 2.

Silver/silver halide supported on mesoporous ceria particles and photo-CWPO degradation under visible light for organic compounds in acrylonitrile wastewater.

Silver/silver halide supported on ordered mesoporous ceria particles (Ag/AgCl/CeO) were rapidly prepared by microwave-assisted soft template method, deposition precipitation method and photoreduction method, using cerium nitrate and silver nitrate as raw materials and block copolymer F127 as a template. The morphology, structure and chemical composition of the catalyst were characterized by XRD, SEM, EDS, TEM, N adsorption-desorption and UV-Vis Drs. Catalytic wet peroxide system assisted with visible light photocatalysis (photo-CWPO) was conducted to investigate the performance of organics degradation by Ag/AgCl/CeO as a catalyst in acrylonitrile wastewater.

Adsorption Characteristics of Gas Molecules Adsorbed on Graphene Doped with Mn: A First Principle Study.

Herein, the adsorption characteristics of graphene substrates modified through a combined single manganese atom with a vacancy or four nitrogen to CHO, HS and HCN, are thoroughly investigated via the density functional theory (DFT) method. The adsorption structural, electronic structures, magnetic properties and adsorption energies of the adsorption system have been completely analyzed. It is found that the adsorption activity of a single vacancy graphene-embedded Mn atom (MnSV-GN) is the largest in the three graphene supports.

Safety and Efficacy of Tranexamic Acid in Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis of Randomized Controlled Trials.

Background: In recent decades, tranexamic acid (TXA) antifibrinolytic therapy before aneurysm clipping or embolization has been widely reported, but its safety and efficacy remain controversial. This meta-analysis evaluated the efficacy and safety of TXA therapy in aneurysmal subarachnoid hemorrhage (aSAH) patients, aiming to improve the evidence-based medical knowledge of treatment options for such patients.

Methods: Pubmed, Web of Science, and Cochrane Library databases were searched up to 1 March 2021 for randomized controlled trials (RCTs).

The Adsorption Behavior of Gas Molecules on Co/N Co-Doped Graphene.

Herein, we have used density functional theory (DFT) to investigate the adsorption behavior of gas molecules on Co/N co-doped graphene (Co/N-gra). We have investigated the geometric stability, electric properties, and magnetic properties comprehensively upon the interaction between Co/N-gra and gas molecules. The binding energy of Co is -5.

Formaldehyde Molecules Adsorption on Zn Doped Monolayer MoS: A First-Principles Calculation.

Based on the first principles of density functional theory, the adsorption behavior of HCO on original monolayer MoS and Zn doped monolayer MoS was studied. The results show that the adsorption of HCO on the original monolayer MoS is very weak, and the electronic structure of the substrate changes little after adsorption. A new kind of surface single cluster catalyst was formed after Zn doped monolayer MoS, where the ZnMo small clusters made the surface have high selectivity.

Detection of organophosphorus pesticides by nanogold/mercaptomethamidophos multi-residue electrochemical biosensor.

Based on the successful synthesis of mercaptomethamidophos as a substrate, a novel nanogold/mercaptomethamidophos multi-residue electrochemical biosensor was designed and fabricated by combining nanoscale effect, strong Au-S bonds as well as interaction between acetylcholinesterase (AChE) and mercaptomethamidophos, which can simultaneously detect 11 kinds of organophosphorus pesticides (OPPs) and total amount of OPPs using indirect competitive method. Electrochemical behavior of the modified electrode was characterized by differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). The AChE concentration and incubation time were optimized at 37.

Investigation of Carbon Nanotube Grafted Graphene Oxide Hybrid Aerogel for Polystyrene Composites with Reinforced Mechanical Performance.

The rational design of carbon nanomaterials-reinforced polymer matrix composites based on the excellent properties of three-dimensional porous materials still remains a significant challenge. Herein, a novel approach is developed for preparing large-scale 3D carbon nanotubes (CNTs) and graphene oxide (GO) aerogel (GO-CNTA) by direct grafting of CNTs onto GO. Following this, styrene was backfilled into the prepared aerogel and polymerized in situ to form GO-CNTA/polystyrene (PS) nanocomposites.

Precipitation of Magnetic Iron Oxide Induced by Cells.

() is bacterium notable for its highly efficient urea degradation ability. Due to its high urease activity, has been successfully utilized in applications including solidifying soil or sand, termed "bio-concrete". In addition to calcium carbonate precipitation, urease isolated from the jack bean plant was recently demonstrated to induce the formation of magnetic iron oxide particles from soluble ferrous ion in a designed reaction.

Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures.

Marine-derived fungi are well known as rich sources of bioactive natural products. Growing evidences indicated that indole alkaloids, isolated from a variety of marine-derived fungi, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities, and therefore, indole alkaloids have potential to be pharmaceutical lead compounds. Systemic compilation of the relevant literature.

BRD4 regulates self-renewal ability and tumorigenicity of glioma-initiating cells by enrichment in the Notch1 promoter region.

Bromodomain and extraterminal domain (BET) family proteins are considered to be epigenetic readers that regulate gene expression by recognizing acetyl lysine residues on histones and nonhistone chromatin factors and have been classified as curative targets for a variety of cancers. Glioma-initiating cells (GICs), which commit self-renewal, perpetual proliferation, multidirectional differentiation, and vigorous tumorigenicity, sustain the peculiar genetic and epigenetic diversification in the GBM patients, thus, GICs result in tumor recurrence. Abundant evidence demonstrates that BET proteins regulate differentiation of stem cells.

Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC.

Glioblastoma (GBM) is the deadliest primary brain tumor that is highly resistant to current treatments. Polo-like kinase 1 (PLK1) and signal transducer and activator of transcription 3 (STAT3) are highly expressed in gliomas, especially GBM. Previous studies have shown reciprocal activation between PLK1 and STAT3 and that they regulate the same pools of MYC downstream.

Detection of Six β-Agonists by Three Multiresidue Immunosensors Based on an Anti-bovine Serum Albumin-Ractopamine-Clenbuterol-Salbutamol Antibody.

According to an indirect competitive immunoassay, six β-agonists (clenbuterol (CL), salbutamol (SAL), ractopamine (RAC), terbutaline (TER), mabuterol (MAB), and tulobuterol (TUL)) were detected by three novel multiresidue immunosensors on the basis of the successful preparation of bovine serum albumin (BSA)-RAC-CL-SAL multideterminant antigen and anti-BSA-RAC-CL-SAL antibody. A new strategy was reported to detect six β-agonists by combining nanotechnology, electrochemical detection, and specific immune technology. At the same concentration, the amperometric response for detection of six β-agonists was in a sequence of GCE/GNP/SAL > GCE/GNP/RAC > GCE/GNP/CL.

Detection of four phenolic oestrogens by a novel electrochemical immunosensor based on a hexestrol monoclonal antibody.

Using a sandwich-type immunoassay, a novel electrochemical immunosensor based on the successful preparation of a hexestrol (HEX) monoclonal antibody was successfully constructed to detect four phenolic oestrogens: HEX, diethylstilboestrol (DES), dienestrol (DE) and bisphenol A (BPA). An innovative strategy to design the HEX monoclonal antibody/mercapto acetic acid (MACA)/nanogold immunosensor was developed by combining a nanosized effect, self-assembly and specific immune technology. The differential pulse voltammetry (DPV) response for four phenolic oestrogens was in the order BPA > DE > HEX > DES with detection limits of 0.

Theoretical Insights on the High Pressure Behavior of Pentazolate Anion Complex [Co(HO)(N)]·4HO.

Periodic dispersion corrected density functional theory (DFT) calculations were carried out to examine the Hirshfeld surface, two dimensional (2D) fingerprint plots, crystal structure, molecular structure and density of state of all-nitrogen pentazolate anion complex [Co(HO)(N)]·4HO under hydrostatic pressure from 0 to 20 GPa. The GGA/PW91-OBS method was applied in the present study. The intercontacts in [Co(HO)(N)]·4HO were analyzed by Hirshfeld surfaces and 2D fingerprint plots.

High pressure behavior of crystal [2,2'-bi(1,3,4-oxadiazole)]-5,5'-dinitramide: A DFT investigation.

Density functional theory (DFT) computation was carried out to investigate the crystal, molecular and electronic structures of high energy crystal [2,2'-bi(1,3,4-oxadiazole)]-5,5'-dinitramide (BODN) with the pressure 0-120 GPa. The relaxed crystal structure by the GGA/PBE-TS functional matches well with the experimental data at ambient pressure condition. With the intensifying of pressure, the lattice parameters, volumes, bond lengths, H-bond energies, atomic charges, bond populations, band gaps and density of states of crystal BODN change gently.