FTO activates PD-L1 promotes immunosuppression in breast cancer via the m6A/YTHDF3/PDK1 axis under hypoxic conditions.

Introduction: Altered epigenetic reprogramming enables breast cancer cells to adapt to hypoxic stress. Hypoxic microenvironment can alter immune cell infiltration and function, limiting the effectiveness of immunotherapy.

Objectives: The study aimed to identify how fat mass and obesity-associated protein (FTO) helps breast cancer cells cope with the hypoxic microenvironment and the mechanisms behind breast cancer cell resistance to tumor immunity.

Time-variant parity-time symmetry in frequency-scanning systems.

Parity-time (PT) symmetry is an active research area that provides a variety of new opportunities for different systems with novel functionalities. For instance, PT symmetry has been used in lasers and optoelectronic oscillators to achieve single-frequency lasing or oscillation. A single-frequency system is essentially a static PT-symmetric system, whose frequency is time-invariant.

NAT10/ac4C/JunB facilitates TNBC malignant progression and immunosuppression by driving glycolysis addiction.

Background: N4-Acetylcytidine (ac4C), a highly conserved post-transcriptional mechanism, plays a pivotal role in RNA modification and tumor progression. However, the molecular mechanism by which ac4C modification mediates tumor immunosuppression remains elusive in triple-negative breast cancer (TNBC).

Methods: NAT10 expression was analyzed in TNBC samples in the level of mRNA and protein, and compared with the corresponding normal tissues.

InsigHTable: Insight-driven Hierarchical Table Visualization with Reinforcement Learning.

Embedding visual representations within original hierarchical tables can mitigate additional cognitive load stemming from the division of users' attention. The created hierarchical table visualizations can help users understand and explore complex data with multi-level attributes. However, because of many options available for transforming hierarchical tables and selecting subsets for embedding, the design space of hierarchical table visualizations becomes vast, and the construction process turns out to be tedious, hindering users from constructing hierarchical table visualizations with many data insights efficiently.

Sticky Links: Encoding Quantitative Data of Graph Edges.

Visually encoding quantitative information associated with graph links is an important problem in graph visualization. A conventional approach is to vary the thickness of lines to encode the strength of connections in node-link diagrams. In this paper, we present Sticky Links, a novel visual encoding method that draws graph links with stickiness.

CoInsight: Visual Storytelling for Hierarchical Tables With Connected Insights.

Extracting data insights and generating visual data stories from tabular data are critical parts of data analysis. However, most existing studies primarily focus on tabular data stored as flat tables, typically without leveraging the relations between cells in the headers of hierarchical tables. When properly used, rich table headers can enable the extraction of many additional data stories.

Intraarticular botulinum toxin type A versus corticosteroid or hyaluronic acid for painful knee osteoarthritis: A meta-analysis of head-to-head randomized controlled trials.

Intraarticular botulinum toxin type A (BTA) has been shown to be effective for painful knee osteoarthritis (KOA), while the efficacy and safety of intraarticular BTA compared to corticosteroid and hyaluronic acid (HA) remains unknown. A meta-analysis was performed to compare. A search was conducted in Medline (PubMed), CENTER (Cochrane Library), Embase (Ovid), Web of Science, Wanfang, and CNKI to find head-to-head randomized controlled trials (RCTs) directly compare the efficacy and safety between intraarticular BTA and intraarticular corticosteroid or HA for patients with painful KOA.

Adaptive therapy: a tumor therapy strategy based on Darwinian evolution theory.

Cancer progression is a dynamic process of continuous evolution, in which genetic diversity and heterogeneity are generated by clonal and subclonal amplification based on random mutations. Traditional cancer treatment strategies have a great challenge, which often leads to treatment failure due to drug resistance. Integrating evolutionary dynamics into treatment regimens may be an effective way to overcome the problem of drug resistance.

LncRNA TINCR impairs the efficacy of immunotherapy against breast cancer by recruiting DNMT1 and downregulating MiR-199a-5p via the STAT1-TINCR-USP20-PD-L1 axis.

Although programmed death-ligand 1 (PD-L1) inhibitors have achieved some therapeutic success in breast cancer, their efficacy is limited by low therapeutic response rates, which is closely related to the immune escape of breast cancer cells. Tissue differentiation inducing non-protein coding RNA (TINCR), a long non-coding RNA, as an oncogenic gene associated with the progression of various malignant tumors, including breast cancer; however, the role of TINCR in tumor immunity, especially in breast cancer, remains unclear. We confirmed that TINCR upregulated PD-L1 expression in vivo and in vitro, and promoted the progression of breast cancer.

Revealing the Potential Markers of N(4)-Acetylcytidine through acRIP-seq in Triple-Negative Breast Cancer.

Understanding the causes of tumorigenesis and progression in triple-receptor negative breast cancer (TNBC) can help the design of novel and personalized therapies and prognostic assessments. Abnormal RNA modification is a recently discovered process in TNBC development. TNBC samples from The Cancer Genome Atlas database were categorized according to the expression level of NAT10, which drives acetylation of cytidine in RNA to N(4)-acetylcytidine (ac4C) and affects mRNA stability.

Increasingly detailed insights in animal behaviours using continuous on-board processing of accelerometer data.

Background: Studies of animal behaviour, ecology and physiology are continuously benefitting from progressing biologging techniques, including the collection of accelerometer data to infer animal behaviours and energy expenditure. In one of the most recent technological advances in this space, on-board processing of raw accelerometer data into animal behaviours proves highly energy-, weight- and cost-efficient allowing for continuous behavioural data collection in addition to regular positional data in a wide range of animal tracking studies.

Methods: We implemented this latest development in collecting continuous behaviour records from 6 Pacific Black Ducks Anas superciliosa to evaluate some of this novel technique's potential advantages over tracking studies lacking behavioural data or recording accelerometer data intermittently only.

GoTreeScape: Navigate and Explore the Tree Visualization Design Space.

Declarative grammar is becoming an increasingly important technique for understanding visualization design spaces. The GoTreeScape system presented in the paper allows users to navigate and explore the vast design space implied by GoTree, a declarative grammar for visualizing tree structures. To provide an overview of the design space, GoTreeScape, which is based on an encoder-decoder architecture, projects the tree visualizations onto a 2D landscape.

A novel nomogram for decision-making assistance on exemption of axillary lymph node dissection in T1-2 breast cancer with only one sentinel lymph node metastasis.

Background: T1-2 breast cancer patients with only one sentinel lymph node (SLN) metastasis have an extremely low non-SLN (NSLN) metastatic rate and are favorable for axillary lymph node dissection (ALND) exemption. This study aimed to construct a nomogram-based preoperative prediction model of NSLN metastasis for such patients, thereby assisting in preoperatively selecting proper surgical procedures.

Methods: A total of 729 T1-2 breast cancer patients with only one SLN metastasis undergoing sentinel lymph node biopsy and ALND were retrospectively selected from Harbin Medical University Cancer Hospital between January 2013 and December 2020, followed by random assignment into training (n=467) and validation cohorts (n=262).

HiTailor: Interactive Transformation and Visualization for Hierarchical Tabular Data.

Tabular visualization techniques integrate visual representations with tabular data to avoid additional cognitive load caused by splitting users' attention. However, most of the existing studies focus on simple flat tables instead of hierarchical tables, whose complex structure limits the expressiveness of visualization results and affects users' efficiency in visualization construction. We present HiTailor, a technique for presenting and exploring hierarchical tables.

Toward Exempting from Sentinel Lymph Node Biopsy in T1 Breast Cancer Patients: A Retrospective Study.

Background And Objective: Sentinel lymph node biopsy (SLNB) is used to assess the status of axillary lymph node (ALN), but it causes many adverse reactions. Considering the low rate of sentinel lymph node (SLN) metastasis in T1 breast cancer, this study aims to identify the characteristics of T1 breast cancer without SLN metastasis and to select T1 breast cancer patients who avoid SLNB through constructing a nomogram.

Methods: A total of 1,619 T1 breast cancer patients with SLNB in our hospital were enrolled in this study.

A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer.

Breast cancer (BRCA) is one of the leading causes of death among women worldwide, and drug resistance often leads to a poor prognosis. Necroptosis is a type of programmed cell death (PCD) and exhibits regulatory effects on tumor progression, but few studies have focused on the relationships between necroptosis-associated lncRNAs and BRCA. In this study, we established a signature basis of 7 necroptosis-related lncRNAs associated with prognosis and divided BRCA patients into high- and low-risk groups.

Effect of Alginate Gelatin Hydrogel Composited with Nano-Zinc on Cesarean Section Wound Healing.

The Surgical procedure of cesarean section (CS) causes a large wound that any delay in its healing could increase the rate of stress, inconvenience, and dissatisfaction among the women who underwent CS procedure about six weeks after childbirth. The present study is trying to evaluate the effect of alginate and gelatin hydrogel composited with nanozinc effective extensibility and compressibility as a wound dressing nursing care after CS. The number of participants was 700 individuals enrolled all who underwent C-sections at Medical College in the Second Affiliated Hospital of Xi'an Jiaotong University (from September 2017 until September 2020).

Leveraging a Joint learning Model to Extract Mixture Symptom Mentions from Traditional Chinese Medicine Clinical Notes.

This paper addresses the mixture symptom mention problem which appears in the structuring of Traditional Chinese Medicine (TCM). We accomplished this by disassembling mixture symptom mentions with entity relation extraction. Over 2,200 clinical notes were annotated to construct the training set.

Question Answering System Based on Knowledge Graph in Traditional Chinese Medicine Diagnosis and Treatment of Viral Hepatitis B.

This article uses the real medical records and web pages of Chinese medicine diagnosis and treatment of hepatitis B to extract structured medical knowledge, and obtains a total of 8,563 entities, 96,896 relationships, 32 entity types, and 40 relationship types. The structured data was stored in the Neo4j graph structure database, and a knowledge graph of Chinese medical diagnosis and treatment of hepatitis B was constructed. The knowledge map is used as a structured data source to provide high-quality knowledge information for the medical question and answer system based on hepatitis B disease.

Knockdown of NAA25 Suppresses Breast Cancer Progression by Regulating Apoptosis and Cell Cycle.

gene variants were reported as risk factors for type 1 diabetes, rheumatoid arthritis and acute arterial stroke. But it's unknown whether it could contribute to breast cancer. We identified rs11066150 in , which contributes to breast cancer, in our earlier genome-wide long non-coding RNA association study on Han Chinese women.

Riddle of the Sphinx: Emerging Role of Transfer RNAs in Human Cancer.

The dysregulation of transfer RNA (tRNA) expression contributes to the diversity of proteomics, heterogeneity of cell populations, and instability of the genome, which may be related to human cancer susceptibility. However, the relationship between tRNA dysregulation and cancer susceptibility remains elusive because the landscape of cancer-associated tRNAs has not been portrayed yet. Furthermore, the molecular mechanisms of tRNAs involved in tumorigenesis and cancer progression have not been systematically understood.

Bandwidth superposition of linearly chirped microwave waveforms based on a Fourier domain mode-locked optoelectronic oscillator.

Optoelectronic oscillators (OEOs) are promising for radar, communication and electronic countermeasure systems. Among them, frequency-scanning OEOs with wide instantaneous bandwidth are needed for many advanced applications. In this work, we demonstrate a novel system to generate bandwidth-doubled linearly chirped microwave waveforms (LCMWs) based on bandwidth superposition using a Fourier domain mode-locked OEO (FDML OEO).

Laser-triggered combination therapy by iron sulfide-doxorubicin@functionalized nanozymes for breast cancer therapy.

Background: The use of magnetic nanozymes (NZs) with the ability to synchronize gas therapy through photodynamic and chemotherapy in the treatment of breast cancer has received much attention.

Results: Hence, in this study, we designed a bovine lactoferrin-coated iron sulfide NZs containing doxorubicin (abbreviated as: FeS-Dox@bLf NZs) by wet-chemical synthesis method. Then, the physicochemical characteristics of synthesized NZs were explored by several methods.