Correction: Development of a carbon quantum dots-based fluorescent Cu probe suitable for living cell imaging.

Correction for 'Development of a carbon quantum dots-based fluorescent Cu probe suitable for living cell imaging' by Qiang Qu , , 2012, , 5473-5475, https://doi.org/10.1039/C2CC31000G.

Hierarchical Porous Aggregate-Enabled Chromatography-Inspired Single-Sensor E-Nose for Volatile Monitoring.

Monitoring volatile organic compounds (VOCs) is crucial for ensuring safety and health. In this study, we introduce a strategy to engineer a chromatography-inspired single-sensor (CISS) e-nose tailored for VOC monitoring. This approach overcomes the limitations of traditional methodologies and conventional e-noses.

Adaptive Phase-Locked E-Skin for Sports Physiology and Medicine.

The pursuit of creating materials that replicate the flexibility, stability, and advanced perceptual capabilities of human skin, attributes honed through natural evolution, represents a long-term objective in pioneering fields such as electronic skin (e-skin) research. However, conventional e-skin often struggles with stability and functionality in harsh sports environments, resulting in the degradation of the intimate interface over time. Inspired by the innate biphasic structure of human subcutaneous tissue, an adaptive phase-locked e-skin (APLE) is presented, designed to seamlessly conform to dynamic sports environments, offering robust applications in sports physiology and medical contexts without malfunctioning.

Biogel Library-Accelerated Discovery of All-Natural Bioelectronics.

Biogels prepared from natural biopolymers are ideal candidates for constructing bioelectronics from the perspective of commercialization and environmental sustainability. However, discovering all-natural biogels that meet specific properties, such as mechanical properties, optical transparency, and stability, remains challenging. Here, our study introduces a revolutionary biogel library, a novel resource that significantly accelerates the discovery and application of suitable all-natural biogel materials for bioelectronics.

Janus Separation-Sensing Membrane Hosted with Enzyme@MOF Nanoreactor for Real-Time Blood Sensing.

Plasma separation, rich in biomarkers crucial for diagnosis, is conventionally achieved via high-speed centrifugation, a method hindered by its blood usage, lengthy processes, and complex operations, which delays detection. We introduced a novel real-time blood sensing method based on a Janus membrane and enzymes @MOFs. Asymmetric driving of the janus membrane can realize spontaneous separation of plasma and prevent hemolysis during direct separation.

Rare Earth-Carbon Dots Nanocomposite-Modified Glass Nanopipettes: Electro-Optical Detection of Bacterial ppGpp.

As an important alarmone nucleotide, guanosine 3'-diphosphate-5'-diphosphate (ppGpp) can regulate the survival of bacteria under strict environmental conditions. Direct detection of ppGpp in bacteria with high sensitivity and selectivity is crucial for elucidating the role of ppGpp in bacterial stringent response. Herein, the terbium-carbon dots nanocomposite (CDs-Tb) modified glass nanopipet was developed for the recognition of ppGpp.

Ultrasensitive sensing urinary cystatin C via an interface-engineered graphene extended-gate field-effect transistor for non-invasive diagnosis of chronic kidney disease.

Early chronic kidney disease (CKD) has strong concealment and lacks an efficient, non-invasive, and lable-free detection platform. Cystatin C (Cys C) in urine is closely related to the progress of CKD (especially at the early stage), which is an ideal endogenous marker to evaluate the impairment of renal function. Thus, the accurate detection of urinary Cys C (u-Cys C) is great significant for early prevention and treatment and delaying the course of the disease of CKD patients.

Room temperature cost-effective synthesis of carbon quantum dots for fluorescence pattern recognition of metal ions.

Herein, a type of low-consuming carbon quantum dot (CD) has been synthesized at room temperature in just 45 minutes Schiff base reaction between -phthalaldehyde (OPA) and polyethyleneimine (PEI). These CDs are pH-dependent, so a novel label-free florescent sensor array can be constructed by utilizing buffers with various pH levels, which leads to distinctive fluorescence response patterns upon being challenged with metal ions for their pattern recognition. The results demonstrate that large-scale detection of metal ions can be achieved with as little as 3 types of sensors.

Multi-engineered Graphene Extended-Gate Field-Effect Transistor for Peroxynitrite Sensing in Alzheimer's Disease.

The expression of β-amyloid peptides (Aβ), a pathological indicator of Alzheimer's disease (AD), was reported to be inapparent in the early stage of AD. While peroxynitrite (ONOO) is produced excessively and emerges earlier than Aβ plaques in the progression of AD, it is thus significant to sensitively detect ONOO for early diagnosis of AD and its pathological research. Herein, we unveiled an integrated sensor for monitoring ONOO, which consisted of a commercially available field-effect transistor (FET) and a high-performance multi-engineered graphene extended-gate (EG) electrode.

Continuous Preparation of Semiconducting Polymer Nanoparticles with Varied Sizes for Online Fluorescence Sensing via a Laser-Tailored 3D Microfluidic Chip.

Microfluidic chips are in critical demand for emerging applications in material synthesis and biosensing. Herein, we relied on ultrafast laser-processing technology to fabricate a three-dimensional (3D) microfluidic chip, in which semiconducting polymer nanoparticles (SPNs) were continuously synthesized with tunable size and SPN-involved online fluorescence sensing was implemented. A homogeneous distribution of SPNs can be readily realized due to the efficient mixing and powerful vortices of the 3D microfluidic chip, which prevents SPNs from aggregating throughout the synthesis process.

Tailoring Food Biopolymers into Biogels for Regenerative Wound Healing and Versatile Skin Bioelectronics.

An increasing utilization of wound-related therapeutic materials and skin bioelectronics urges the development of multifunctional biogels for personal therapy and health management. Nevertheless, conventional dressings and skin bioelectronics with single function, mechanical mismatches, and impracticality severely limit their widespread applications in clinical. Herein, we explore a gelling mechanism, fabrication method, and functionalization for broadly applicable food biopolymers-based biogels that unite the challenging needs of elastic yet injectable wound dressing and skin bioelectronics in a single system.

Au/Lum/RhB@Ag-DMcT ICP-Based Double-Ratio Colorimetric and Fluorometric Dual Mode Assay and Multi-Responsive Coffee Ring Chips for Point-of-Use Analysis of Phosphate Ions.

In this work, by fully exploring the stimulus response of the guest-functionalized infinite coordination polymers (ICPs), a double-ratio colorimetric and fluorometric dual mode assay and multi-responsive coffee ring chips for point-of-use analysis of phosphate ions (Pi) were proposed. First, the complex host-guest interactions were rationally designed to obtain Au/Lum/RhB@Ag-DMcT ICPs. The composite ICPs exhibited a purple-blue color resulted from the modulated localized surface plasmon resonance (LSPR) of the Au core, and a blue fluorescence color stemmed from the unique aggregation-induced-emission (AIE) of Luminol (Lum) and the aggregation-caused-quenching (ACQ) of rhodamine B (RhB).

Wearable Clinic: From Microneedle-Based Sensors to Next-Generation Healthcare Platforms.

The rapid development of wearable biosensing calls for next-generation devices that allow continuous, real-time, and painless monitoring of health status along with responsive medical treatment. Microneedles have exhibited great potential for the direct access of dermal interstitial fluid (ISF) in a minimally invasive manner. Recent studies of microneedle-based devices have evolved from conventional off-line detection to multiplexed, wireless, and integrated sensing.

Ultrasensitive therapeutic drug monitoring of methotrexate by a structure-switching aptamer with cascade primer exchange reaction.

As a folate antagonist, methotrexate (MTX) has been widely used in clinics with good effects on various tumors and inflammatory diseases. While the optimum dosage and total body clearance of MTX usually varies between individuals and even low-dose MTX has side effects, high-dose MTX may cause life-threatening side effects. Therefore, a convenient and simple method toward MTX sensing is highly demanded.

Stimuli-responsive polymers for interface engineering toward enhanced electrochemical analysis of neurochemicals.

Neurochemical monitoring can provide important insights into the chemical communications in the brain and neurological diseases. Although electrochemical sensors have promoted the development of neurochemical analysis, the limited analytical performance of the existing sensors restrict our understanding of the roles that chemical signals play in the brain. The central nervous system is composed of a large number of neurochemical species.

Modular Assembly of MXene Frameworks for Noninvasive Disease Diagnosis via Urinary Volatiles.

Volatile organic compounds (VOCs) in urine are valuable biomarkers for noninvasive disease diagnosis. Herein, a facile coordination-driven modular assembly strategy is used for developing a library of gas-sensing materials based on porous MXene frameworks (MFs). Taking advantage of modules with diverse composition and tunable structure, our MFs-based library can provide more choices to satisfy gas-sensing demands.

Aptamer-engineered extended-gate field-effect transistor device for point-of-care therapeutic drug monitoring.

Herein, we report a portable point-of-care testing (POCT) device based on an aptamer-engineered extended-gate field-effect transistor (EG-FET) for therapeutic monitoring of the drug methotrexate. This method was shown to be highly sensitive, efficient, and convenient to use, features contributing to its realizing a clinical detection of drugs in blood.

Debonding-On-Demand Polymeric Wound Patches for Minimal Adhesion and Clinical Communication.

Herein, a multifunctional bilayer wound patch is developed by integrating a debonding-on-demand polymeric tissue adhesive (DDPTA) with an ionic conducting elastomer (ICE). As a skin adhesive layer, the DDPTA is soft and adherent at skin temperature but hard and non-tacky when cooled, so it provides unique temperature-triggered quick adhesion and non-forced detachment from the skin. During use, the dense surface of the DDPTA prevents blood infiltration and reduces unnecessary blood loss with gentle pressing.

Rational design of MoS QDs and Eu as a ratiometric fluorescent probe for point-of-care visual quantitative detection of tetracycline via smartphone-based portable platform.

The abuse of the antibiotic tetracycline (TC) has resulted in its residues in the environment and animals, which has caused irreversible damage to public health safety and environments. Therefore, it is urgently needed to develop alternative sensitive and low-cost for quickly and accurately detection the TC residues in the environments. We innovatively rational design of MoS QDs and Eu to construct ratiometric fluorescent probe to detect TC.

Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations.

Wound dressings based on nanomaterials play a crucial role in wound treatment and are widely used in a whole range of medical settings, from minor to life-threatening tissue injuries. This article presents an educational review on the accumulating knowledge in this multidisciplinary area to lay out the challenges and opportunities that lie ahead and ignite the further and faster development of clinically valuable technologies. The review analyzes the functional advantages of nanomaterial-based gauzes and hydrogels as well as hybrid structures thereof.

Rational design of a self-assembled surfactant film in nanopipettes: combined fluorescence and electrochemical sensing.

Herein, a generalizable method based on the formation of a self-assembled surfactant film was reported to build a nanopipette system. Using this nanopipette, it was found that arginine metabolism shows an age-related difference in Alzheimer's disease.

High-Performance Extended-Gate Field-Effect Transistor for Kinase Sensing in Aβ Accumulation of Alzheimer's Disease.

An amyloid-beta peptide (Aβ) is generally believed to be a pathological marker of Alzheimer's disease (AD), but it is still of great significance to explore the upstream and downstream relationship of Aβ in AD. It is previously reported that c-Abl, a nonreceptor tyrosine kinase, can be activated by Aβ, but the interaction between Aβ and c-Abl is still unknown. Herein, an extended-gate field-effect transistor (EG-FET)-based sensor has been developed to monitor the level of c-Abl with high sensitivity and selectivity.

Interface engineering with self-assembling Au@Ag@β-cyclodextrin bimetal nanoparticles to fabricate a ring-like arrayed SERS substrate for sensitive recognition of phthalate esters based on a host-guest interaction and the coffee ring effect.

Herein, Au@Ag@β-cyclodextrin (β-CD) nanoparticles with a relatively uniform shape and size of ∼13 nm in diameter have been successfully synthesized, and the surfaces of the synthesized nanoparticles are successful modified by β-CD. A highly efficient synthetic approach was developed for the preparation of a surface-enhanced Raman spectroscopy (SERS) substrate, which self-assembles Au@Ag@β-CD nanoparticles and analytes into a coffee ring pattern the coffee ring effect. The coffee ring effect can make phthalates (PAEs) aggregate to the edge together with the Au@Ag@β-CD nanoparticles and concentration enrichment can be achieved.

Monitoring of pH in Subacute PD Mouse Brains with a Ratiometric Electrochemical Microsensor Based on Poly(melamine) Films.

monitoring of cerebral pH is of great significance because its disturbance is related to some pathological processes such as neurodegenerative diseases, for example, Parkinson's disease (PD). In this study, we developed an electrochemical microsensor based on poly(melamine) (P) films for ratiometric monitoring of pH in subacute PD mouse brains. In this microsensor, P films were prepared from a simple electropolymerization approach in a melamine-containing solution, serving as the selective pH recognition membrane undergoing a 2H/2e process.

A dual-channel colorimetric and fluorescent sensor for the rapid and ultrasensitive detection of kanamycin based on gold nanoparticles-copper nanoclusters.

In this work, a dual-channel assay was constructed for the colorimetric and fluorescent detection of kanamycin (KAN) based on gold nanoparticles (Au NPs) and copper nanoclusters (Cu NCs). Initially, the fluorescence of Cu NCs was quenched by 4-amino-3-hydrazino-5-mercapto-1,2,4-triazole (AHMT)-functionalized Au NPs due to the inner filter effect (IFE). The existence of KAN acted as a molecular bridge to interact with AHMT hydrogen bonds and induced the aggregation of AHMT-Au NPs, leading to a change in the color of the gold colloidal solution from reddish-violet to blue within 2 min.