Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants Compared with Vitamin K Antagonists in Patients with Atrial Fibrillation and Type 2 Valvular Heart Disease: A Systematic Review and Meta-Analysis.

Purpose: This meta-analysis aimed to evaluate the efficacy and safety of non-vitamin K antagonist oral anticoagulants (NOACs) compared with vitamin K antagonists (VKAs) in patients with atrial fibrillation (AF) and type 2 valvular heart disease (VHD).

Methods: We searched the PubMed, LILACS, and MEDLINE databases to retrieve, randomized controlled trials (RCTs) comparing NOACs and VKAs in patients with AF and type 2 VHD, excluding mitral stenosis (moderate to severe, of rheumatic origin) or mechanical heart valves. The efficacy outcomes assessed were stroke and systemic embolism (SE), while safety outcomes included major bleeding and intracranial hemorrhage (ICH).

Biological characteristics of manganese transporter MntP in .

is an important opportunistic pathogen that causes a variety of infections. It is critical for bacteria to maintain metal homeostasis during infection. By using an isogenic deletion mutant of strain NTUH-K2044, we found that MntP was a manganese efflux pump.

GPR30 selective agonist G-1 induced insulin resistance in ovariectomized mice on high fat diet and its mechanism.

Background: Previous in vivo and in vitro studies have demonstrated that estrogen receptor agonist G-1 regulates glucose and lipid metabolism. This study focused on the effects of G-1 on cardiometabolic syndrome and anti-obesity under a high fat diet (HFD).

Methods: Bilateral ovariectomized female mice were fed an HFD for 6 weeks, and treated them with G-1.

[Niche of the mosses on floor in Shanghai City].

The mosses on the floor of 22 sites at 20 main parks and 2 chemical plants in Shanghai were sampled, and 75 moss species were recorded. Their niche breadths were calculated by Levins equation. The results indicated that most moss species had rather narrow niche breadth, 68% of them with a niche breadth less than 0.

[Distribution patterns of moss species in Shanghai city].

The mosses on the floor of 22 sites at 20 main parks and 2 chemical plants in Shanghai city were investigated and sampled. Based on 75 recorded moss species and their coverage, Two-way Indicator Species Analysis (TWINSPAN) and Detrended Correspondence Analysis (DCA) were used to analyze their distribution patterns. The results showed that the study sites could be identified as three groups.