MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease.

Parkinson's disease (PD), one of the most devastating neurodegenerative brain disorders, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN) and deposits of α-synuclein aggregates. Currently, pharmacological interventions for PD remain inadequate. The cell necroptosis executor protein MLKL (Mixed-lineage kinase domain-like) is involved in various diseases, including inflammatory bowel disease and neurodegenerative diseases; however, its precise role in PD remains unclear.

Rainwater extracting characteristics and its potential impact on DBPs generation: A case study.

Frequent extreme precipitation events due to global warming can lead to large amounts of pollutants entering source water bodies via surface runoff and wet deposition, thus posing a threat to water supply security. In order to better understand the source characteristics and leaching mechanisms of rainwater dissolved organic matter (DOM), as well as its disinfection by-products formation potential (DBPsFP) during disinfection processes, rainwater samples were collected and extracting experiments were conducted. Three components were identified in rainwater through Parallel factor (PARAFAC) analysis, which were microbial humic-like component C1 (63.

Formation characteristics and acute toxicity assessment of THMs and HAcAms from DOM and its different fractions in source water during chlorination and chloramination.

The formation characteristics of trihalomethanes (THMs) and haloacetamides (HAcAms) from dissolved organic matter and its fractions were investigated during chlorine-based disinfection processes. The relationships between water quality parameters, fluorescence parameters, and the formation levels of THMs and HAcAms were analyzed. The fractions contributing most to the acute toxicity were identified.

[Seasonal change of habitat selection of in Yancheng coastal wetlands, China].

Yancheng coastal wetlands are one of the main habitats and breeding grounds of wild Chinese water deer (). Based on GPS-GSM tracking data, we used the habitat selection index and MaxEnt model to simulate and analyze the distribution of suitable habitat of in different seasons as well as the main influencing factors. The results showed that mainly used reed marshes, with the usage rate in spring-summer and autumn-winter being 52.

p Components of Cluster-Lag Consensus for Second-Order Multiagent Systems With Adaptive Controller on Cooperative-Competitive Networks.

The consensus tracking problem means that a group of followers tracks the desired trajectory with local communication. In this article, partial components of cluster consensus have been considered. In this scenario, the p components of the followers in different clusters track the leader at different lag times, while p components of each agent in the same cluster reach a consensus, which is called p components of cluster-lag (PCCL) consensus.

Chronic effects of microcystin-LR at environmental relevant concentrations on photosynthesis of Typha angustifolia Linn.

Understanding the growth and development of aquatic plants in eutrophic water is of great significance for the selection of potential candidate plant for use in the phytoremediation of eutrophic aquatic ecosystems. The present study aimed to investigate the chronic effects of microcystin-LR (MC-LR) on photosynthesis in the leaves of Typha angustifolia Linn. Photosynthetic activity was stimulated in the leaves following exposure to 4.

Comparison of acetaminophen degradation in UV-LED-based advance oxidation processes: Reaction kinetics, radicals contribution, degradation pathways and acute toxicity assessment.

Ultraviolet light emitting diode (UV-LED)-based advanced oxidation processes (AOPs) including UV-LED/chloramine (UV-LED/NHCl), UV-LED/hydrogen peroxide (UV-LED/HO) and UV-LED/persulfate (UV-LED/PS), were adopted for acetaminophen (AAP) removal. Results showed that AAP could be effectively degraded by the hybrid processes compared to solely using with UV irradiation and oxidants. The AAP degradation in the three UV-LED-based AOPs were in the order of UV-LED/PS > UV-LED/HO > UV-LED/NHCl and followed a pseudo-first-order kinetics.

Nitrogen Metabolism in Acorus calamus L. Leaves Induced Changes in Response to Microcystin-LR at Environmentally Relevant Concentrations.

Acorus calamus L., a semiaquatic plant with a high capacity to remove nitrogen and phosphorus from polluted water, is a potential candidate plant for use in the restoration of eutrophic aquatic ecosystems. However, it is not clear how microcystins (MCs), commonly found in eutrophic water, influence plant growth since the effects of MCs are likely to be dose and species dependent.

Subcellular distribution, chemical forms, and physiological response to cadmium stress in Hydrilla verticillata.

This study investigated the subcellular distribution and chemical forms of cadmium (Cd) in Hydrilla verticillata and the physiological mechanism underlying H. verticillata responses to Cd stress. Hydrilla verticillata was grown in a hydroponic system and was treated with various Cd concentrations (0, 10, 50, 100, 125, and 150 µM) for 7 days.

Functional Silencing of in Prostate Cancer Promotes Disease Progression.

Purpose: Steroidogenic enzymes are essential for prostate cancer development. Enzymes inactivating potent androgens were not investigated thoroughly, which leads to limited interference strategies for prostate cancer therapy. Here we characterized the clinical relevance, significance, and regulation mechanism of enzyme in prostate cancer development.

Degradation of triclosan by chlorine dioxide: Reaction mechanism,2,4-dichlorophenol accumulation and toxicity evaluation.

The mechanism and toxicity of TCS degradation by ClO was investigated. Intermediate products during the oxidation process were identified by GC/MS and LC/MS. A microtox bioassay and a SOS/umu assay were employed to evaluate the acute toxicity and genotoxicity of the resulting solutions during the chlorination process.

Degradation behavior of triclosan by co-exposure to chlorine dioxide and UV irradiation: influencing factors and toxicity changes.

This study investigated the transformation of triclosan (TCS) following co-exposure to UV irradiation and ClO. Special attention was given to understand the influencing of water quality parameters and toxicity changes during the co-exposure process. The results show that the co-exposure process prompted TCS elimination quickly and effectively, with more than 99% of TCS degraded under the experimental conditions.

[Efficiency and Kinetics of Triclosan Degradation in Aqueous Solution by UV/Sodium Persulfate].

UV activated sodium persulfate was employed to remove triclosan (TCS) in aqueous solution. The effects of several factors such as UV wavelength,UV intensity,sodium persulfate dosage,pH value,and HA on TCS degradation were investigated. The second-order rate constants of free radicals (·OH, SO) reacting with TCS and their contributions to TCS removal were determined,respectively.

The Effects of Occupational Exposure of Carbon Disulfide on Sexual Hormones and Semen Quality of Male Workers From a Chemical Fiber Factory.

Objective: This study is aimed to analyze the relationship between occupational CS2 exposure and reproductive impairments.

Methods: Seventy-six CS2-exposed (9.73 ± 2.

DEVELOPMENT AND IMPLEMENTATION OF A PRACTICAL PUBLIC HEALTH TRAINING SYSTEM IN CHINA.

Public health education is becoming an increasing priority among educators of medicine. In China, little attention has been paid to public health education reform. A new public health training system was introduced in China in 2007.

[Removal of triclosan with the method of UV/ClO2 and its degradation products].

The UV/ClO2 process for triclosan ( TCS) removal was studied. The influences of several factors such as the initial pH, dose of ClO2, initial concentration of TCS and humic acid( HA) on TCS degradation in the UV/ClO2 combined process were discussed. The results showed that the UV/ClO2 process could effectively remove TCS and had a synergistic effect.

Role of Endoplasmic reticulum apoptotic pathway in testicular Sertoli cells injury induced by Carbon disulfide.

The exposure of Carbon disulfide (CS2) is associated with germ cell injury and male infertility in animals and humans. However, the molecular mechanism is currently unknown. This study show here that CS2-induced Sertoli cells injury via Endoplasmic reticulum (ER) apoptotic pathway.

Carbon disulfide induces rat testicular injury via mitochondrial apoptotic pathway.

Carbon disulfide (CS2), one of the most important volatile organic chemicals, was shown to have serious impairment to male reproductive system. But the underline mechanism is still unclear. In the present study, we aim to investigate the male germ cell apoptosis induced by CS2 exposure alone and by co-administration with cyclosporin A (CsA), which is the inhibitor of membrane permeability transition pore (MPTP).

[Effect of carbon disulfide on mitochondrial apoptosis-related proteins in cytoplasm of testicular tissue among male rats].

Objective: To investigate the role of mitochondrial pathway in the apoptosis of spermatogenic cells induced by inhalation of carbon disulfide in male rats.

Methods: Twenty-four male Sprague-Dawley rats (clean grade) were divided into four groups according to their body weights: three CS(2) exposure groups (CS(2) concentrations: 50, 250, and 1250 mg/m(3)) and a control group. The rats in CS(2) exposure groups were exposed to CS(2) by static inhalation for 10 weeks (2 h/d, 5 d/w), while the rats in control group were exposed to air.

[Effect of carbon disulfide on mitochondrial respiratory chain in spermatogenic cells in male rats].

Objective: To investigate the effect of carbon disulfide (CS(2)) on the mitochondrial respiratory chain in testicular spermatogenic cells in male rats and to explore the possible mechanism of reproductive system damage caused by CS(2) in male rats.

Methods: Twenty-four male Sprague-Dawley rats (clean grade) were randomly divided into four groups: three CS(2) exposure groups (CS(2) concentrations: 50, 250, and 1250 mg/m(3)) and a control group. The rats in CS(2) exposure groups were exposed to CS(2) by static inhalation for 10 weeks (2 h/d, 5 d/w), while the rats in control group were exposed to air.

[Effect of maternal BDE-209 exposure on sexual development in male offspring rats].

Objective: To investigate the effect of maternal decabromodiphenyl ether (BDE-209) exposure on the sexual development in male offspring rats.

Methods: Twenty-four pregnant Sprague-Dawley rats were randomly divided into three BDE-209 exposure groups and one control group. The three BDE-209 exposure groups were given BDE-209 (100, 300, and 900 mg/kg) by gavage on gestational days 12∼18, and the control group was given corn oil.

Nitric oxide mediated effects on reproductive toxicity caused by carbon disulfide in male rats.

This study investigated nitric oxide (NO) mediation of carbon disulfide (CS(2)) toxicity that compromised male rat spermatogenesis and endocrine function. Rats were exposed to multiple levels of CS(2) concentration (0, 50, 250, 1250 mg/m(3)). A 1250 mg/m(3) CS(2)+sodium nitroprusside (SNP) group and a 1250 mg/m(3) CS(2)+NG-monomethyl-L-arginine (L-NMMA) group were established to explore the role of NO in mediating CS(2) toxicity.