Publications by authors named "Guoying Luo"

It is commonly known that radiotherapy is still a key modality for treatment of cancer. Though this effect is desirable during radiotherapy, it leads to radiotoxicity on normal healthy cells. In the present research, we designed, synthesized and analyzed a series of nitronyl nitroxide radical (NITR) spin-labeled resveratrol (RES) derivatives.

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A novel reversed/hydrophilic chromatographic stationary phase based on dialdehyde microcrystalline cellulose (DMCC)-functionalized C was prepared by covalent bonding between the amino groups of octadecylamine with the aldehyde groups of DMCC, which was used in reversed-phase liquid chromatography (RPLC) and hydrophilic interaction liquid chromatography (HILIC) modes. The prepared DMCC-functionalized C modified silica (C-DMCC/SiO) stationary phase exhibited good hydrophobic selectivity and aromatic selectivity by separating alkylbenzenes and polycyclic aromatic hydrocarbons (PAHs) in the RPLC mode. Polar compounds, including anilines, phenols, and glycosides were chosen as analytes to evaluate the polar selectivity of this column in the RPLC mode, and the evaluation results were satisfactory compared with the commercial C column.

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A new strategy for the preparation of mixed-mode chromatographic stationary phases based on modified dialdehyde cellulose was proposed. Two novel mixed-mode chromatographic stationary phases, dicarboxyl cellulose-modified silica (DCC/SiO) and (S)-α-phenylethylamine-bonded DCC/SiO ((S)-α-PEA/DCC/SiO), were prepared by utilizing the easy functionalization characteristics of dialdehyde cellulose. The chromatographic evaluation showed that DCC/SiO column could be used in hydrophilic interaction liquid chromatography (HILIC) and ion exchange chromatography (IEC) modes, (S)-α-PEA/DCC/SiO column could be used in HILIC, IEC and chiral separation modes.

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Broad spectrum separation of chiral compounds is a challenge task for analysts. It is significant for preparation of chiral stationary phase and selection of separation technology in the field. Here, we present a novel nanocellulose crystals (NCCs) which were derivation with 3,5-dimethylphenyl isocynate (DMPC) and silane with 3-triethoxysilylpropylisocyanate form sol in tetraethylorthosilicate (TEOS) and layer-by-layer self-assembly in the inner of capillary to fabricate the organic-inorganic hybrid open tubular capillary column (DMPC/NCCs-OTC) for enantiomers separation by capillary electrochromatography technology (CEC).

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A concise and stereoselective synthesis of the trioxadispiroketal motif that embodies the DEF-ring of the marine macrolide (+)-spirastrellolide A is described. The synthetic approach features a sequence of cyclic acetal tethered ring-closing metathesis and Suárez oxidative cyclization, thereby constituting a viable strategy for constructing the Northern Half.

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