Publications by authors named "Guoying Liao"
Article Synopsis
- The study investigates the mechanisms behind perioperative neurocognitive disorders (PND), particularly in older patients after anesthesia and surgery, focusing on cognitive dysfunction linked to sevoflurane anesthesia.
- Using advanced RNA sequencing, researchers analyzed gene expression changes in excitatory neurons of aged mice to understand how sevoflurane affects cognitive function.
- Results revealed that sevoflurane reduces glutamatergic synapses in the hippocampus, indicating a significant link between synaptic alterations and cognitive decline in aged mice.
Background: METTL3, an mRNA mA methyltransferase, has been implicated in various steps of mRNA metabolism, such as stabilization, splicing, nuclear transportation, translation, and degradation. However, whether METTL3 dysregulation is involved in Hirschsprung disease (HSCR) development remains unclear. In this study, we preliminarily elucidated the role of METTL3 in HSCR and sought to identify the associated molecular mechanism.
View Article and Find Full Text PDFBackground: There are numerous published studies on the association between polymorphisms and susceptibility to Hirschsprung disease (HSCR). However, some of the results are inconsistent and the studies were conducted with small sample sizes. Therefore, we performed a meta-analysis to clarify the relationship.
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