Carmiseconapine A as a Promising Antidepressant Candidate: An Adenosine 5'-Monophosphate-Activated Protein Kinase Agonist with an Unprecedented Chemical Skeleton.

A novel rearranged C-diterpenoid alkaloid, carmiseconapline A (), featuring a unique 10,20:11,12-di--napelline skeleton with a fused 5/6/5/6/7 pentacyclic ring system, was isolated from Debeaux. Compound exhibited remarkable antidepressive activity, being twice as potent as fluoxetine (10 mg/kg) at 0.06 mg/kg in mice.

NOD-like receptor protein 3 inhibitors in St. John's wort and their potential antidepressant effects.

Depression is a chronic mental disorder characterized by persistent low mood and loss of interest, often associated with dysregulation of neuroinflammatory pathways. Inhibition of NOD-like receptor protein 3 (NLRP3), a key mediator of neuroinflammation, is a promising strategy for alleviating depressive symptoms by modulating inflammatory responses in the brain. Seven polycyclic polyprenylated acylphloroglucinols (PPAPs), including six new hyperioxides A-F (1-6) and furohyperforin (7) were isolated from St.

Amelioration of gap junction dysfunction in a depression model by loganin: Involvement of GSK-3β/β-catenin signaling.

Ethnopharmacological Relevance: Cornus officinalis Sieb. et Zucc has significant neuroprotective activity and has been widely studied for its potential to improve cognitive function. Our team's previous research has found that loganin isolated from Cornus officinalis has an antidepressant effect.

New polycyclic polyprenylated acylphloroglucinols with antidepressant activities from Hypericum perforatum L.

Six new polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperidiones A-F (1-6), were obtained from Hypericum perforatum L. Their structures were characterized via extensive spectroscopic analyses, the circular dichroism data of the in situ formed [Mo(OCOCH)] complexes, the nuclear magnetic resonance calculation with DP4 probability analysis, and the calculated electronic circular dichroism (ECD) spectra. Compounds 1-6 are bicyclic polyprenylated acylphloroglucinols with a major bicyclo[3.