Publications by authors named "Guoyan Shen"
Article Synopsis
- Hepatocellular carcinoma (HCC) is a serious cancer where the role of autophagy is complex, acting as both a promoter and inhibitor of tumor growth.
- A focus of the study is the autophagy-related protein WDR45B, which was found to be upregulated in HCC and can affect the Akt/mTOR signaling pathway, influencing essential autophagy markers.
- Knockdown of WDR45B not only inhibited cancer cell proliferation and migration but also suggested its potential as a new biomarker for assessing HCC prognosis and a target for future therapies.
Pancreatic cancer (PC) is one of the most fatal malignancies. Pyroptosis, a type of inflammatory cell death, likely plays a critical role in the development and progression of tumors. However, the relationship between pyroptosis-related genes (PRGs) and prognosis and immunity to PC is not entirely clear.
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- The study focuses on the role of WOX1 in cucumber leaf development, particularly how it influences lamina growth and vein formation.
- A mutant cucumber variant with a truncated WOX1 protein shows improper leaf expansion and vein structure, indicating WOX1's critical role in these processes.
- Research findings suggest that WOX1 regulates leaf development by affecting auxin transport and interacting with specific genes, which ultimately impacts leaf size and patterning.