Inhibiting the MAPK pathway improves heart failure with preserved ejection fraction induced by salt-sensitive hypertension.

Heart failure (HF) preserved ejection fraction (HFpEF) accounts for almost 50% of HF, and hypertension is one of the pathogenies. The MAPK signaling pathway is closely linked to heart failure and hypertension; however, its function in HEpEF resulting from salt-sensitive hypertension is not well understood. In this work, a salt-sensitive hypertension-induced HEpEF model was established based on deoxycorticosterone acetate-salt (DOCA-salt) hypertension mice.

The function of guanylate binding protein 3 (GBP3) in human cancers by pan-cancer bioinformatics.

As a guanylate binding protein (GBPs) member, GBP3 is immune-associated and may participate in oncogenesis and cancer therapy. Since little has been reported on GBP3 in this field, we provide pan-cancer bioinformatics to investigate the role of GBP3 in human cancers. The GBP3 expression, related clinical outcomes, immune infiltrates, potential mechanisms and mutations were conducted using tools including TIMER2.

Rectal nonsteroidal anti-inflammatory drugs, glyceryl trinitrate, or combinations for prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis: A network meta-analysis.

Background: Acute pancreatitis is the most common and severe complication of endoscopic retrograde cholangiopancreatography (ERCP). Recent evidence suggests that combinations based on rectal nonsteroidal anti-inflammatory drugs (NSAIDs) are more beneficial in preventing post-ERCP pancreatitis (PEP). Randomized controlled trials (RCTs) have also demonstrated the efficacy of glyceryl trinitrate (GTN).

Infection as a Risk Factor for Abnormal Serum Protein Levels in General Population of China.

Background: (HP) infection is considered as a risk factor for nutritional and metabolic abnormalities, and serum protein is an important marker of the nutritional and immune status. It is still unknown whether HP infection affects serum protein levels.

Methods: The participants who underwent health screening from July 2020 to August 2021 were included, among whom, 1485 subjects with 14C-urea breath test (14C-UBT) values ≥100 disintegrations per minute (dpm) were defined as HP-positive cases, and 4864 cases with 14C-UBT values <100 dpm were defined as HP-negative cases.

PDM-16QAM transmission of 135 GBaud enabled by 120 GSa/s DAC and Tomlinson-Harashima pre-coding.

We experimentally verified that Tomlinson-Harashima (TH) pre-coding for an optical coherent system can enhance the speed of polarization division multiplexing (PDM) 16 quadrature amplitude modulation (QAM) signal to be higher than 135 GBaud with 120 GSa/s digital-to-analog converter (DAC) and electrical/optical/electrical bandwidth of the system narrower than 57 GHz at -30. The improvement of achievable capacity based on the received SNR in optical back-to-back conditions could be obviously observed by comparing the PDM-16QAM signal with and without TH pre-coding. The normalized generalized mutual information of the 135 GBaud PDM-16QAM signal for 120 km standard single mode fiber transmission was much higher than the threshold of error-free operation of a 5/6 code rate of digital video broadcasting satellite second generation low-density parity check forward error correction.

Effect of computer navigation-assisted minimally invasive direct lateral interbody fusion in the treatment of patients with lumbar tuberculosis: A retrospective study.

The benefits of navigation-assisted technologies are not entirely understood. Therefore, this study aimed to examine the outcomes of patients with lumbar tuberculosis who received computer navigation-assisted minimally invasive direct lateral interbody fusion (DLIF).This was a retrospective study of 33 patients with lumbar tuberculosis who underwent minimally invasive DLIF at the Department of Spine and Orthopedics of Guigang People's Hospital (Guangxi, China) between January 2015 and December 2016.

Straightforward method for measuring optical fiber's nonlinear coefficient based on phase mismatching FWM.

A novel method for measuring optical fiber's nonlinear coefficient, based on phase mismatching four-wave mixing is proposed. Measurements for both high nonlinearity dispersion shifted fiber and low nonlinearity standard single mode fiber are demonstrated with simple setup. Chromatic dispersion is also measured with high precision simultaneously, and therefore its effect to the nonlinear coefficient measurement can be removed.

All-optical technique for modulation format conversion from NRZ-OOK to RZ-16QAM employing nonlinear optical loop mirror with 1:2 coupler.

All-optical technique for modulation format conversion from 4 channels non-return-to-zero on-off-keying (OOK) to return-to-zero 16 quadrature amplitude modulation (16QAM) employing nonlinear optical loop mirror with 1:2 coupler configuration is proposed and experimentally demonstrated at 10Gs/s. The experimentally converted 16QAM signal was distorted in its phase by cross-phase modulation induced amplitude-to-phase noise conversion. The effect of amplified spontaneous emission noise in the amplified OOK signals to the converted 16QAM's phase was theoretically discussed.