Publications by authors named "Guoxin Jin"
Article Synopsis
- Researchers created chiral structures like triangular prisms and cuboid cages using a self-assembly process driven by coordination chemistry.
- They utilized flexible tartrate ligands with diverse coordination properties to form these structures, carefully adjusting their lengths and metal components to achieve different designs.
- The study employed advanced techniques like X-ray diffraction and spectroscopy to analyze the assembled structures and established a method for building complex chiral cage-like entities.
Article Synopsis
- * The research successfully demonstrates a topological transformation from a figure-eight knot to a Solomon link by using amino acid ligands of varying lengths as bridge ligands.
- * This achievement marks the creation of the first heteroleptic Solomon link made from two different metallamacrocycles and showcases the ability to manipulate structures and properties through minor adjustments in the ligands.
Spinal scoliosis: insights into developmental mechanisms and animal models.
Spine Deform
January 2025
Spinal scoliosis, a prevalent spinal deformity impacting both physical and mental well-being, has a significant genetic component, though the exact pathogenic mechanisms remain elusive. This review offers a comprehensive exploration of current research on embryonic spinal development, focusing on the genetic and biological intricacies governing axial elongation and straightening. Zebrafish, a vital model in developmental biology, takes a prominent role in understanding spinal scoliosis.
View Article and Find Full Text PDFArticle Synopsis
- This research focuses on creating a new bipyridyl ligand (L1) using a noncoplanar terphenyl, which then forms two unique metalla-knots through coordination with half-sandwich metal units.
- The study explores the introduction of nitrogen atoms to L1 for managing steric repulsion during the assembly of these complexes, enabling a transition from metalla-knots to more complex structures like pseudo-Solomon links and molecular tweezer-like assemblies.
- Various techniques like NMR, ESI-TOF/MS, and X-ray diffraction were utilized to thoroughly characterize these assemblies, highlighting the interplay between steric hindrance and stacking interactions in structuring different molecular topologies.
Article Synopsis
- Researchers introduced a new method for assembling mechanically interlocked molecules (MIMs) using a combination of coordination and noncovalent interactions like π-π stacking and CH⋯π interactions to create complex structures like molecular links, knots, and Borromean rings.
- The assembly was achieved by utilizing specifically designed ligands combined with a certain type of organometallic clip, demonstrating how varying the size and properties of these components influenced the resulting molecular structures.
- This innovative approach not only provides a pathway for synthesizing intricate MIMs but also highlights the importance of noncovalent interactions in their formation, confirmed through various analytical techniques like NMR and X-ray diffraction.*
Article Synopsis
- Researchers aim to expand the use of carboranes, which have shown better stability in certain metal-carbon interactions compared to traditional alkyl or aryl groups.
- Experimental and theoretical studies revealed a unique M⋯C-H interaction where a carbon atom from an arene contributes electrons to a metal, distinguishing it from other types of metal-carbon bonding.
- The findings highlight the special electronic properties of carboranes and suggest that the M⋯C-H interaction can transform into a more stable C-H bond under specific conditions, opening up new possibilities in organometallic chemistry.
Article Synopsis
- The article discusses challenges in finding efficient and user-friendly methods for modifying molecular structures, specifically in postassembly transformations.
- It details successful experiments using a specific ligand and reactive components to create two types of molecular trefoil knots with high yields.
- The research highlights the importance of modifying the sterics of specific fragments to facilitate the conversion of trefoil knots to Solomon links, supported by advanced analytical techniques.
Article Synopsis
- A method was created to connect o-carborane groups to form new carboranyl dithioester ligands through a specific substitution process involving haloalkanes.
- These ligands allowed for a notable direct B-H activation with half-sandwich iridium (Ir(III)) complexes, achieving bimetallic or trimetallic structures without needing additional support from silver(I) or alkali.
- Analysis of the resulting complexes revealed successful B(3)-H activation and provided insight into their structures through single crystal analysis.
Efficient and Selective Construction of 4 Metalla-links Using Weak C-H⋅⋅⋅Halogen Interactions.
Angew Chem Int Ed Engl
June 2024
Article Synopsis
- - A coordination-driven self-assembly method produced four metalla-links and one tetranuclear monocycle with high selectivity and yield by altering the building block substituents, confirmed through various analytical techniques like X-ray crystallography and NMR spectroscopy.
- - The introduction of halogens (F, Cl, Br, I) enhanced weak C-H⋅⋅⋅X interactions, which significantly contributed to the formation of the metalla-links.
- - The study also explored how metalla-links convert to monocyclic rings in methanol solution, utilizing quantitative H NMR techniques for analysis.
Intervertebral disc degeneration (IDD) poses a significant health burden, necessitating a deeper understanding of its molecular underpinnings. Transcriptomic analysis reveals 485 differentially expressed genes (DEGs) associated with IDD, underscoring the importance of immune regulation. Weighted gene co-expression network analysis (WGCNA) identifies a yellow module strongly correlated with IDD, intersecting with 197 DEGs.
View Article and Find Full Text PDFmiR-221-3p has been reported to attenuate the osteogenic differentiation of annulus fibrosus cells (AFs), which has been implicated in intervertebral disk degeneration (IVDD) development. This study aimed to elucidate miR-221-3p's role in osteogenic differentiation and apoptosis of AFs in an IVDD model. After successfully establishing an IVDD rat model by annulus fibrosus needle puncture, AFs were isolated.
View Article and Find Full Text PDFArticle Synopsis
- Researchers successfully created a linear metalla[4]catenane in a single step using a special ligand and a rhodium precursor, overcoming previous challenges in the field.
- The assembly was driven by strong interactions such as π-π stacking and non-classical hydrogen bonding among the components.
- They also discovered that changing the aromatic groups on the rhodium precursor allowed for the creation of two different metalla[2]catenanes, with their structures confirmed using X-ray diffraction and other techniques.
Controllable Topological Transformations of 8 Molecular Metalla-knots by Oxidation of Thiazole-Based Ligands.
Angew Chem Int Ed Engl
November 2023
By exploiting coordination-driven self-assembly, high yields of two 8 molecular metalla-knots could be obtained using a thiazole-moiety-containing asymmetric dipyridyl ligand 2-(pyridin-4-yl)-5-(pyridin-4-ylethynyl)benzo[d]thiazole (L ), as confirmed using X-ray crystallographic analysis, electrospray ionization-time-of-flight/mass spectrometry (ESI-TOF/MS), and detailed liquid-state nuclear magnetic resonance (NMR) spectroscopy. To modulate the self-assembled structures, m-chloroperbenzoic acid (m-CPBA) was utilized to oxidize thiazole-based ligand L to N-thiazole-oxide-based ligand 2-(pyridin-4-yl)-5-(pyridin-4-ylethynyl)benzo[d]thiazole 3-oxide (L ), which enabled the selective construction of the corresponding tetranuclear macrocycles. Notably, two molecular metalla-knots could be topologically transformed from 8 knots to simple monocycles because the L alkyne bond was inert toward m-CPBA, as confirmed by liquid-state NMR spectroscopy, ESI-TOF/MS, and elemental analysis.
View Article and Find Full Text PDFArticle Synopsis
- * Challenges in carborane development, such as activating B-H bonds, can be addressed through careful selection of metal centers and ligands.
- * Although research in this area is still emerging, recent findings on weak interactions in carboranes suggest potential advancements in supramolecular applications, particularly for alkane separation.
Article Synopsis
- Developing new methods for assembling supramolecular compounds has been a challenging area of research.
- This study combines B-C coupling reactions with a process called "cage walking" to create supramolecular cages using dipyridine linkers.
- By varying the length of the linkers, researchers can control the size and type of structures formed, which could lead to innovative applications in supramolecular chemistry.
Intricately interwoven topologies are continually being synthesized and are ultimately equally versatile and significant at the nanoscale level; however, reports concerning ravel structures, which are highly entwined new topological species, are extremely rare and fraught with tremendous synthesis challenges. To solve the synthesis problem, a tetrapodontic pyridine ligand L1 with two types of olefinic bond units and two Cp*M-based building blocks (E1, M=Rh; E2, M=Ir) featuring large conjugated planes was prepared to perform the self-assembly. Two unprecedented [5+10] icosanuclear molecular 4-ravels containing four crossings were obtained by parallel-displaced π⋅⋅⋅π interactions in a single-step strategy.
View Article and Find Full Text PDFArticle Synopsis
- * The research shows how varying the length of bipyridyl ligands can facilitate the transformation from a binuclear D-shaped ring to a tetranuclear [2]catenane.
- * Different naphthyl group positions on the bipyridyl ligand enable the selective synthesis of [2]catenane and Borromean rings under the same experimental conditions.
Article Synopsis
- The text discusses the creation of metalla-links, which are complex structures made up of molecular Borromean rings and cyclic catenanes, achieved through specific chemical interactions.
- These structures were synthesized using unique tri-methoxyl-dinuclear complexes as cationic guests, leading to high yield formations.
- The arrangement and type of metalla-links were meticulously controlled by choosing two different dipyridyl ligands, with their configuration analyzed using X-ray crystallography and advanced NMR techniques.
Constructing the backbones of polymers with metal atoms is an attractive strategy to develop new functional polymeric materials, but it has yet to be studied due to synthetic challenges. Here, metal atoms are interconnected as the backbones of polymers to yield metal-backboned polymers (MBPs). Rational design of multidentate ligands synthesized via an efficient iterative approach leads to the successful construction of a series of nickel-backboned polymers (NBPs) with well-defined lengths and up to 21 nickel atoms, whose structures are systematically confirmed.
View Article and Find Full Text PDFOrganometallic Borromean Rings and [2]Catenanes Featuring Di-NHC Ligands.
Angew Chem Int Ed Engl
March 2023
Article Synopsis
- This research focuses on creating organometallic Borromean rings (BRs) and [2]catenanes using benzobiscarbene ligands through self-assembly with specific dinickel complexes and a bridging ligand.
- Solvophobic effects significantly influence both the formation and stability of these interlocked structures, with stability being enhanced by longer alkyl substituents on the precursors.
- An equilibrium between [2]catenanes and their building blocks is established in solution, and higher concentrations of [2]catenanes are favored in concentrated solutions or polar solvents, further improved by longer N-alkyl substituents.
Stereoselective Construction of Chiral Linear [3]Catenanes and [2]Catenanes.
J Am Chem Soc
January 2023
We have successfully constructed a chiral linear [3]catenane stereoselectively by coordination-driven self-assembly using a ditopic monodentate ligand containing l-valine residues with a binuclear half-sandwich organometallic rhodium(III) unit. Furthermore, by increasing the steric hindrance of the amino acid residues in the ligand, a chiral [2]catenane was obtained, which can be regarded as the factor catenane of the chiral linear [3]catenane from a topological viewpoint. Notably, the resulting molecular catenanes all exhibit complex coconformational mechanical helical chirality and planar chirality ascribed to the point chirality of the ligands.
View Article and Find Full Text PDFArticle Synopsis
- Researchers developed rectangular carborane-based metallacycles that can effectively separate -pentane from mixtures with -pentane and -pentane, addressing challenges in distinguishing alkanes with similar structures.
- The metallacycles achieve a high purity level of 97% in the separation process, thanks to their ability to selectively interact with -pentane through size matching and specific chemical interactions.
- The carborane-based metallacycles can be recycled for repeated use after separation, and their design allows for potential applications in various separation challenges across different chemical compounds.
Article Synopsis
- Recent advancements in supramolecular architecture synthesis have led to the creation of new metalla[2]catenanes and Borromean ring assemblies using specific Cp*Rh building blocks and alkynyl pyridine ligands.
- Minor variations in the ligand structure caused significant differences in the resulting topology of these assemblies, highlighting the impact of structural design.
- The study found that π-π stacking interactions are essential for stabilizing these complexes and enhancing their near-infrared photothermal conversion efficiencies, making them promising materials for future applications in materials science.
Article Synopsis
- Separation of light hydrocarbons, like cyclohexane, is crucial for various industries, and boron clusters offer unique structures that can enhance this process.
- Researchers designed a special metallacage that uses specific ligands to efficiently capture cyclohexane from a mixture with benzene, achieving a high purity of 98.5%.
- The selective trapping of cyclohexane and cyclohexene in the metallacage is due to various weak interactions and suggests potential future applications in advanced chemistry for separating hydrocarbons.
We report a design strategy for integrative assembly of heteromeric [2]catenanes. The design focuses on the shape and functional group match of two different metalla-rectangles. A series of dipyridyl ligands with different lengths, widths and functional groups were designed and used for assembly experiments.
View Article and Find Full Text PDF