System dynamics modeling of collaborative governance in smart cities: a case study of Dongguan, China.

The smart city, characterized by its complexity and expansiveness, entails intricate collaborative governance processes involving a multitude of elements. We have established a smart city collaborative governance system and formulated a system dynamics model based on the interaction dynamics among the internal elements of the collaborative governance subsystems: the subject, object, and environment. Policy adjustment variables were carefully selected to simulate six policy combination scenarios, illustrating the developmental trajectory of Dongguan City's smart city collaborative governance system from 2015 to 2030, within the context of various policy paradigms.

Cracking the code of teacher burnout: the chain mediation of GPT integration degree through behavioral engagement and classroom atmosphere in a cross-level chain mediation model.

Chat GPT technology plays a pivotal role in global educational innovation and the enhancement of the quality of teaching and learning. In the field of education research, numerous studies have been conducted to investigate the effectiveness of GPT technology, teacher acceptance, and student engagement in depth. To date, few studies have considered the compounding effects of these factors on teacher burnout from the perspectives of psychology and behavioral sciences in conjunction with the dichotomous and complex relationship between teachers and students.

Investigating the Mechanical Characteristics and Fracture Morphologies of Basalt Fiber Concrete: Insights from Uniaxial Compression Tests and Meshless Numerical Simulations.

To explore the mechanical properties and fracture modes of basalt fiber-reinforced concrete, single-doped and hybrid-doped basalt fiber-reinforced concrete was prepared, and uniaxial failure tests under different basalt fiber-reinforced concrete contents were carried out. At the same time, the smooth kernel function in the traditional SPH method was improved, and the basalt fiber random generation algorithm was embedded in the SPH program to realize the simulation of the progressive failure of basalt fiber-reinforced concrete. The results show that under the circumstance with no basalt fiber, the specimen final failure mode is damage on the upper and lower surface, as well as the side edge, while the interior of the specimen center is basically intact, indicating that there is an obvious stress concentration phenomenon on the upper and lower surface when the specimen is compressed.

Nd:YVO/YVO cascaded Raman laser pumped dual-wavelength signal wave MgO:PPLN-OPO with wide range adjustable wavelength interval.

This article presents a dual-wavelength signal wave output system capable of generating a broad range of adjustable wavelength intervals. The setup involved the creation of a dual-wavelength cascaded Raman laser featuring composite cavities operating at 1176 nm and 1313 nm. Experimental investigations were carried out on an external cavity MgO:PPLN-OPO driven by the cascaded Raman laser.

Construction and Simulation of High-Quality Development of China's Resource-Based Cities Driven by Innovation Based on System Dynamics.

Innovation is the primary driving force for development; the high-quality development of resource-based cities is ultimately driven by innovation. We constructed an innovation-driven high-quality development system for resource-based cities, including resource, economic, social, and environmental subsystems; according to the interaction between the internal elements of each subsystem, a dynamic model of the innovation-driven high-quality development system of resource-based cities was established, and we selected policy adjustment variables to simulate six policy scenarios. Thus, we simulated high-quality development trends from 2008 to 2035.

Evolution of the Raman beam quality in a folded-coupled-cavity Nd:YVO/YVO Raman laser.

An end-pumped actively $Q$Q-switched ${\rm Nd}\!:\!{{\rm YVO}_4}/{{\rm YVO}_4}$Nd:YVO/YVO Raman laser with a folded coupled cavity is demonstrated to study the evolution of Raman beam quality. The theoretical mechanism of the beam cleanup effect of stimulated Raman scattering is analyzed. The beam quality ($M^2$M) of the Raman beam and the fundamental beams before and after the Raman conversion are measured experimentally.

Identification of distinct blood-based biomarkers in early stage of Parkinson's disease.

Parkinson's disease (PD) is a slowly progressive geriatric disease, which can be one of the leading causes of serious socioeconomic burden in the aging society. Clinical trials suggest that prompt treatment of early-stage Parkinson's disease (EPD) may slow down the disease progress and have a better response. Therefore, conducting proteomics study to identify biomarkers for the diagnosis and disease-modifying therapies of EPD is vital.

IL-18 induced IL-23/IL-17 expression impairs Aβ clearance in cultured THP-1 and BV2 cells.

Recent studies have provided overwhelming evidence of the involvement of microglia-related molecular networks in the pathogenesis of Alzheimer's diseases (AD). The potential involvement of pro-inflammatory cytokines interleukin (IL)-18, IL-23 and IL-17 on amyloid (Aβ) clearance is still unclear. In this study, we addressed that there might be a net relationship among IL-18, IL-23, and IL-17 and they can affect Aβ clearance in cultured macrophage/microglia cells.

TRPC6 mRNA levels in peripheral leucocytes of patients with Alzheimer's disease and mild cognitive impairment: A case-control study.

Background: Transient receptor potential canonical (TRPC) 6 inhibits Aβ in Alzheimer's disease (AD) mouse brain and improves the behavioral performance.

Aims: To evaluate the association of TRPC6 expression in peripheral leucocytes from AD and mild cognitive impairment (MCI) patients and to explore its potential value in early diagnosis of AD.

Methods: TRPC6 mRNA levels in peripheral leucocytes were detected by quantitative real-time PCR.

Association of neck circumference and cognitive impairment among Chinese elderly.

Objectives: To investigate the association between neck circumference (NC) and cognitive impairment and interactions between relevant variables to the risk of cognitive impairment.

Methods: A population-based survey was conducted among elderly inhabitants aged 60 years and over from a community in Shanghai suburb. Multivariate logistic regression analyses were performed to evaluate associations and log likelihood ratio tests to examine interactions.

Serum haptoglobin in Chinese patients with Alzheimer's disease and mild cognitive impairment: A case-control study.

Background: Serum level of Haptoglobin (Hp) maybe associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI).

Objective: To investigate associations between serum Hp and AD, as well as between Hp and MCI.

Methods: Serum levels of Hp were measured and analyzed for 51 patients with AD, 139 patients with MCI and their healthy controls matched with sex and age.

Metabolic Syndrome and Mild Cognitive Impairment: A Case-Control Study among Elderly in a Shanghai Suburb.

Background: Metabolic syndrome (MetS) maybe associated with mild cognitive impairment (MCI).

Objective: To investigate the relationship between MetS, with its individual or combined components, and MCI among elderly.

Methods: A case-control study was conducted among the elderly aged 65 years and over in a community located in the southwestern suburb of Shanghai, China.

Peripheral Blood MicroRNA Expression Profiles in Alzheimer's Disease: Screening, Validation, Association with Clinical Phenotype and Implications for Molecular Mechanism.

A series of investigations have been performed regarding microRNA (miRNA, miR) of Alzheimer's disease (AD) patients. However, most of these used microarray with neither validation by PCR nor any follow-up on the biological mechanism implicated by findings. Further, there were rarely any analyses linking clinical phenotype of de novo, drug-naive patients to cellular pathogenic mechanism(s) to date.

Increased serum levels of interleukin-18, -23 and -17 in Chinese patients with Alzheimer's disease.

Aims: To evaluate the serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with Alzheimer's disease (AD), and explore correlations between the three cytokines and relevant parameters.

Methods: Serum concentrations of IL-18, IL-23 and IL-17 were measured by ELISA for 53 AD patients and 53 sex- and age-matched healthy controls in a community of elderly individuals in a Shanghai suburb.

Results: Serum concentrations of IL-18, IL-23 and IL-17 were significantly higher in AD patients than controls.

Cognitive impairment among elderly individuals in Shanghai suburb, China: association of C-reactive protein and its interactions with other relevant factors.

Objectives: To investigate the association between serum C-reactive protein (CRP) concentration and cognitive impairment as well as interactions between CRP and other relevant factors.

Methods: Patients with cognitive impairment and 1 to 2 age- and sex-matched controls nested from a population-based study among residents aged 60 years and older in Shanghai suburb. The associations of serum CRP concentration and other relevant factors were examined with logistic regression analysis.

Dementia among elderly in Shanghai suburb: a rural community survey.

The number of elderly in the world is increasing rapidly, especially in China. The prevalence of dementia among elderly was investigated in a community of Sheshan town, located in the Southwest suburb of Shanghai, China. Face-to-face interviews were conducted to collect relevant information with prepared questionnaires.

The association of weight status with cognitive impairment in the elderly population of a Shanghai suburb.

Objective: A population-based survey was conducted to analyze the association of under-weight, blood pressure, glucose and lipid metabolism with cognitive impairment in people, 60 years and over, living in 2 towns of Shanghai.

Methods: Face-to-face interviews were carried out to collect relevant information with questionnaires. Anthropometric indices of height, weight, waist circumference (WC) and hip circumference were measured.

Serum level of interleukin-6 in Chinese patients with multiple sclerosis.

The aim of this study was to investigate the serum concentration of interleukin (IL)-6 in patients with relapsing-remitting MS (RR-MS), compare the difference between males and females, and explore the correlation between the serum concentration of IL-6 and clinical parameters like the current age, the age at onset, disease duration, disability (expanded disability status scale, EDSS), and the number of relapse. We compared the serum concentration of IL-6 in 39 patients with MS and 39 healthy controls matched with sex and age. The serum IL-6 concentration was measured by FlowCytomix.

Serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with multiple sclerosis.

It has been reported that cytokines play an important role in the pathogenesis of multiple sclerosis (MS). The aim of this study was to evaluate the serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with MS. We compared the serum concentrations of pro-inflammatory cytokines IL-18, IL-23 and IL-17 in 39 patients with MS and 39 healthy controls matched with sex and age.

Evaluation of anthropometric indices for metabolic syndrome in Chinese adults aged 40 years and over.

Background: The prevalence of metabolic syndrome (MetS) is increasing worldwide with a marked impact in cardiovascular disease (CVD) and diabetes risk.

Aim Of The Study: To evaluate the anthropometric indices for metabolic syndrome (MetS) and determine the optimal cut-off values of waist circumference (WC), body mass index (BMI), and waist height ratio (WHtR) for MetS in Chinese adults aged 40 years and over.

Methods: A sample of Chinese adults aged 40 years and over including 430 men and 638 women was investigated.

Serotonin transporter gene polymorphism in Chinese patients with poststroke depression: a case-control study.

Background And Purpose: We sought to compare the distribution of the serotonin transporter gene SLC6A4 polymorphism between depressed and nondepressed poststroke patients.

Methods: Patients with cerebral stroke admitted to hospital during a 1-year period were enrolled in a 1:1 case-control study. All cases and controls were genotyped for polymorphism of the serotonin transporter-linked promoter region and the single-nucleotide polymorphism rs25531.

Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: a HuGE review and meta-analysis.

The association between glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms and oral cancer is not consistent across studies, and data on their interaction with smoking in oral cancer are lacking. The authors systematically searched PubMed and SciVerse Scopus for case-control studies examining the association between null genotypes of the GSTM1 and GSTT1 genes and oral cancer. Twenty-eight case-control studies published in English were identified.

Time interval between stroke onset and hospital arrival in acute ischemic stroke patients in Shanghai, China.

Objective: To observe the time interval between stroke onset and hospital arrival (time-to-hospital) in acute ischemic stroke patients and analyze its putatively associated factors.

Methods: During the period from November 1, 2006 to August 31, 2008, patients with acute ischemic stroke admitted consecutively to the Department of Neurology, Ninth Hospital, Shanghai, were enrolled in the study. Information of the patients was registered including the time-to-hospital, demographic data, history of stroke, season at attack, neurological symptom at onset, etc.