Evaluation of deterioration degree and consolidation effectiveness in sandstone and clay brick materials based on the micro-drilling resistance method.

The quick and accurate measurement and evaluation of the deterioration degree and consolidation effectiveness on the surface of masonry relics is valuable for disease investigation and restoration work. However, there is still a lack of quantitative indices for evaluating the deterioration degree and consolidation effectiveness of masonry relics in situ. Based on the micro-drilling resistance method, new quantitative evaluation indices for the deterioration degree and consolidation of masonry materials were proposed.

Seismic response investigation of prestressed anchor cable supporting rock slope with weak interlayer in Qinghai-Tibet Plateau, China.

Earthquake-induced rock landslides in the eastern mountains of the Tibetan Plateau, especially landslides with weak interlayers pose a significant threat to major construction projects. Prestressed anchor cable is one of the main reinforcement methods of rock slopes. This paper combines shaking table model tests and numerical simulation to study the reinforcement effect and dynamic response characteristics of prestressed anchor cables applied to rock slopes with weak interlayers under strong earthquakes.

Isolation of a Virulent Strain from and Characterization by Whole-Genome Sequence Analysis.

() is an important veterinary pathogen and a noteworthy threat to human and animal health. Recently, there has been a significant rise in the number of moose fatalities caused by this rare, endemic species in China. Currently, there is an increasing trend in conducting whole-genome analysis of strains originating from pigs and chickens, whereas fewer studies have been undertaken on -originating strains at the whole-genome level.

Advanced photocatalytic disinfection mechanisms and their challenges.

Currently, microbial contamination issues have globally brought out a huge health threat to human beings and animals. To be specific, microorganisms including bacteria and viruses display durable ecological toxicity and various diseases to aquatic organisms. In the past decade, the photocatalytic microorganism inactivation technique has attracted more and more concern owing to its green, low-cost, and sustainable process.

Accelerated electron and mass transfer through constructing HWO/TiC/g-CN Z-scheme photocatalyst for environmental remediation.

The catalytic efficiency of photocatalysts highly depends on electron transport and mass transfer. Herein, we designed and prepared an effective HWO/TiC/g-CN (HTC) Z-scheme heterojunction through interfacial engineering strategy. The results manifested that 97.

Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.

Immuno-oncology (IO)-based therapies such as checkpoint inhibitors, bi-specific antibodies, and CAR-T-cell therapies have shown significant success in the treatment of several cancer indications. However, these therapies can result in the development of severe adverse events, including cytokine release syndrome (CRS). Currently, there is a paucity of in vivo models that can evaluate dose-response relationships for both tumor control and CRS-related safety issues.

The strong interaction and confinement effect of Ag@NH-MIL-88B for improving the conversion and durability of photocatalytic Cr(VI) reduction in the presence of a hole scavenger.

Selectively regulating active factors in photocatalytic reactions by designing materials is one of the very important factors. Herein, we prepared spindle-like core-shell Ag@NH-MIL-88B composites (Ag@NM-88) by a two-step hydrothermal method. The as-prepared Ag@NM-88 displayed superior photocatalytic activity for Cr(VI) reduction under LED light, compared with the activities of pure NH-MIL-88B (NM-88) and Ag/NM-88 (Ag was deposited on NH-MIL-88B).

Exceptional visible-light photoelectrocatalytic activity of dual Z-scheme Bi@BiOI-BiO/CN heterojunction for simultaneous remediation of Cr(VI) and phenol.

Developing highly efficient and stable photocatalysts remains a major challenge for the remediation of environmental pollutants. In this work, the Bi decorated BiOI-BiO/CN heterojunction (Bi@BiOI-BiO/CN) film was fabricated through ultrasonic stripping, I etching and in situ UV-reduction processes and then characterized thoroughly by various analytical techniques. The characteristics of simultaneous mitigation of phenol and Cr(VI) were evaluated over Bi@BiOI-BiO/CN photoanode under visible light.

The clinical value of indirect immunofluorescence for screening anti-rods and rings antibodies: A retrospective study of two centers in China.

Objective: To investigate the distribution and clinical significance of the rods and rings (RR) pattern in various diseases.

Methods: A total of 169,891 patients in Peking Union Medical College Hospital (PUMCH) and 29,458 patients in Inner Mongolia People's Hospital (IMPH) from January 2018 to December 2020 were included, and the results of ANA (antinuclear antibodies) and special antibodies were analyzed retrospectively.

Results: The positive rates of ANA and RR patterns were 34.

Highly Pathogenic Avian Influenza A (H5N1) Virus in Swans, Central China, 2021.

Six highly pathogenic avian influenza (HPAI) H5N1 viruses (clade 2.3.4.

Decreased CD57 expression of natural killer cells enhanced cytotoxicity in patients with primary sclerosing cholangitis.

Background/aims: Primary sclerosing cholangitis (PSC) is a chronic inflammatory biliary disease for which the immunopathological basis remains an enigma. Natural killer (NK) cells are key components of innate immunity and seemingly play diversified roles in different autoimmune disorders (AIDs). The aim of this study was to determine the role of NK cells in the pathogenesis of PSC.

Genetic and Pathogenic Characterization of Avian Influenza Virus in Migratory Birds between 2015 and 2019 in Central China.

Active surveillance of avian influenza virus (AIV) in wetlands and lakes is important for exploring the gene pool in wild birds. Through active surveillance from 2015 through 2019, 10,900 samples from wild birds in central China were collected, and 89 AIVs were isolated, including 2 subtypes of highly pathogenic AIV and 12 of low-pathogenic AIV; H9N2 and H6Ny were the dominant subtypes. Phylogenetic analysis of the isolates demonstrated that extensive intersubtype reassortments and frequent intercontinental gene exchange occurred in AIVs.

Ecology of avian influenza viruses in migratory birds wintering within the Yangtze River wetlands.

Migratory birds are considered natural reservoirs of avian influenza A viruses (AIVs). To further our viral ecology knowledge and understand the subsequent risk posed by wild birds, we conducted a 4-year surveillance study of AIVs in the bird wintering wetlands of the Yangtze River, China. We collected over 8000 samples and isolated 122 AIV strains.

E. coli and the etiology of human PBC: Antimitochondrial antibodies and spreading determinants.

Background And Aims: The increased frequency of urinary tract infections in patients with primary biliary cholangitis (PBC) and the cross-reactivity between the lipoyl domains (LD) of human pyruvate dehydrogenase complex (hPDC-E2) and Escherichia coli PDC-E2 (ePDC-E2) have long suggested a role of E. coli in causality of PBC. This issue, however, has remained speculative.

Emerging highly pathogenic avian influenza (H5N8) virus in migratory birds in Central China, 2020.

Eleven highly pathogenic avian influenza H5N8 viruses (clade 2.3.4.

Glycomic analysis of antibody indicates distinctive glycosylation profile in patients with autoimmune cholangitis.

Glycosylation of antibodies, particularly in the Fc domain, critically modulate the ability of antibodies to bind to FcRs, maintaining immune quiescence to achieve a finely orchestrated immune response. The removal of sialic acid and galactose residues dramatically alters the physiological function of IgGs, and alterations of Ig glycosylation have been associated with several autoimmune disorders. However, Ig glycosylation has not been extensively studied in autoimmune cholangitis.

Novel Reassortant Avian Influenza A(H9N2) Virus Isolate in Migratory Waterfowl in Hubei Province, China.

In December 2017, an influenza A(H9N2) virus (B51) was isolated from migratory waterfowl in Hubei Province, China. Phylogenetic analysis demonstrated that B51 is a novel reassortant influenza virus containing segments from human H7N4 virus and North American wild bird influenza viruses. This suggest that B51 has undergone multiple reassortment events.

Estimation of nonlinear water-quality trends in high-frequency monitoring data.

Recent advances in high-frequency water-quality sensors have enabled direct measurements of physical and chemical attributes in rivers and streams nearly continuously. Water-quality trends can be used to identify important watershed-scale changes driven by natural and anthropogenic influences. Statistical methods to estimate trends using high-frequency data are lacking.

Cholangiocarcinoma in Patients with Primary Sclerosing Cholangitis (PSC): a Comprehensive Review.

Cholangiocarcinoma (CCA) is the most common malignancy in patients with primary sclerosing cholangitis (PSC) and carries a high rate of mortality. Although the pathogenesis of CCA in PSC is largely unknown, inflammation-driven carcinogenesis concomitant with various genetic and epigenetic abnormalities are underlying factors. The majority of CCA cases develop from a dominant stricture (DS), which is defined as a stricture with a diameter < 1.

Therapeutic trials of biologics in primary biliary cholangitis: An open label study of abatacept and review of the literature.

Primary biliary cholangitis (PBC) is a classic autoimmune disease in which humoral, cytotoxic, and innate immune responses have been implicated with the specific targeting of a mitochondrial antigen. The mainstay of treatment remains the bile acid ursodeoxycholic acid (UDCA). Corticosteroids may have some benefits, but to date, clinical trials of biologics targeting B cells and IL-12/23 have not shown any efficacy.

Microbiota and Food Allergy.

Emerging evidence suggests that the increasing prevalence of food allergies is associated with compositional and functional changes in our gut microbiota. Microbiota-host interactions play a key role in regulating the immune system. Development of a healthy gut microbiota and immune system occurs early in life and is largely shaped by exposure to maternal microbes through vaginal/natural delivery and breast milk, whereas use of antibiotics can disrupt gut homeostasis and significantly raise the risk of allergic diseases.

Anti-drug Antibodies Against a Novel Humanized Anti-CD20 Antibody Impair Its Therapeutic Effect on Primary Biliary Cholangitis in Human CD20- and FcγR-Expressing Mice.

There is considerable interest in expanding B cell-targeted therapies in human autoimmune diseases. However, clinical trials in human primary biliary cholangitis (PBC) using a chimeric antibody against human CD20 (hCD20) have showed limited efficacy. Two potential explanations for these disappointing results are the appearance of anti-drug antibodies (ADAs) and the high frequency of patients with moderate PBC or patients who had failed ursodeoxycholic acid treatment.

Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016.

Since 2016, the highly pathogenic avian influenza H5N8 virus has emerged in the Central Asian flyway and Europe, causing massive deaths in poultry and wild birds. In this study, we isolated and identified three H5N8 viruses from swan goose and black swans in Hubei province during the 2016/2017 winter season. Whole-genome sequencing and phylogenetic analysis revealed that the three viruses clustered into a group of H5N8 viruses from Qinghai Lake and Europe.