Publications by authors named "Guoxia Fan"
Potential Action Mechanism of Erianin in Relieving MNNG-triggered Chronic Atrophic Gastritis.
Cell Biochem Biophys
September 2024
Article Synopsis
- Chronic atrophic gastritis (CAG) is a key precursor for gastric cancer, and Erianin has potential as a treatment for its precancerous lesions.
- The study aimed to explore Erianin's effects on CAG by creating a cell model from human gastric epithelium and assessing cell viability, inflammation, oxidative stress, and autophagy.
- Results showed that Erianin reversed the negative impacts of MNNG treatment on cell viability and inflammation while inhibiting the mTOR/MAPK signaling pathway, suggesting it may enhance autophagy and contribute to CAG management.
Diabetic nephropathy (DN), a common microvascular complication of type 2 diabetes mellitus (T2DM), causes increasing mortality and morbidity due to its high prevalence and severe consequences. Hence, it is urgent to search for effective agents that provide new insights into novel molecular therapeutic targets for DN. This study was designed to investigate the critical role of Akebia saponin D (ASD) in kidney damage, inflammation and apoptosis of renal tubular cells in DN.
View Article and Find Full Text PDF[Study of gene chips in the detection of YMDD mutations in the region of HBV polymeras].
Zhonghua Yi Xue Za Zhi
March 2003
Objective: To understand mutations of the HBV polymerase from the level of molecule-biology and to guide reasonably antiviral therapy in clinic and predict prognosis of the patients, the gene chips were applied to detect YMDD mutations for the serum samples with HBV DNA position before antiviral therapy.
Methods: The serum samples from 150 HBV DNA positive patients non-antiviral therapy were detected by nowly advanced gene chip technique for YMDD wildtype and YVDD and/or YIDD mutations in the region of HBV polymerase. Several positive samples had been testified by gene sequences.