Multidimensional screen exposure and its impact on psychological well-being in toddlers.

Objective: Previous studies have indicated a link between screen exposure and children's mental health, but with the emergence of new screen media and a rise in screen content, uncertainties have grown. Our aim was to investigate the impact of screen use on psychological issues in 2- to 3-year-old children, considering screen time and types of screen media and content.

Methods: This cross-sectional study included participants from Shanghai, China, from February to July 2023.

Development of A Nanostructured Lipid Carrier-Based Drug Delivery Strategy for Apigenin: Experimental Design Based on CCD-RSM and Evaluation against NSCLC In Vitro.

Non-small-cell lung cancer (NSCLC) is the main cause of cancer-related deaths worldwide, with a low five-year survival rate, posing a serious threat to human health. In recent years, the delivery of antitumor drugs using a nanostructured lipid carrier (NLC) has become a subject of research. This study aimed to develop an apigenin (AP)-loaded nanostructured lipid carrier (AP-NLC) by melt sonication using glyceryl monostearate (GMS), glyceryl triacetate, and poloxamer 188.

Benefit from a high store visiting cost in an omnichannel with BOPS.

Omnichannel sales surge in the coronavirus pandemic. This paper establishes an analytical model to study when a firm can benefit from implementing the omnichannel strategy of buy-online and pick-up in-store (BOPS), where the market characteristics are captured by the two-dimensional heterogeneity of product valuation and online waiting cost. The increase in the store visiting cost will reduce BOPS consumers' willingness to pay, but it will also strengthen the encroachment of BOPS on traditional dual-channel.

An investigation of integrating the finite element method (FEM) with grey system theory for geotechnical problems.

Numerical simulation is very important to solve geotechnical problems. However, it is difficult to obtain required comprehensive and accurate information such as parameters, boundary conditions, and etc. In this paper, a grey distributed parameter model, which integrates the finite element method (FEM) with the grey system theory, was proposed to address the issue.

Screening for Autism Spectrum Disorder in Toddlers During the 18- and 24-Month Well-Child Visits.

Objective: Early screening contributes to the early detection of children with autism spectrum disorder (ASD). We conducted a longitudinal ASD screening study in a large community setting. The study was designed to investigate the diagnostic rate of ASD screening and determine the effectiveness of ASD screening model in a community-based sample.

Engineering Nanointerfaces of Au Clusters for Chaperone-Mediated Peptide Amyloidosis.

Synthetic nanomaterials possessing biomolecular-chaperone functions are good candidates for modulating physicochemical interactions in many bioapplications. Despite extensive research, no general principle to engineer nanomaterial surfaces is available to precisely manipulate biomolecular conformations and behaviors, greatly limiting attempts to develop high-performance nanochaperone materials. Here, we demonstrate that, by quantifying the length (-SCR, = 3-11) and charges (R = -COO, R = -NH) of ligands on Au gold nanochaperones (AuNCs), simulating binding sites and affinities of amyloid-like peptides with AuNCs, and probing peptide folding and fibrillation in the presence of AuNCs, it is possible to precisely manipulate the peptides' conformations and, thus, their amyloidosis via customizing AuNCs nanointerfaces.

Determination of the 90% Effective Dose of Phenylephrine Boluses to Treat Spinal Anesthesia-Induced Hypotension in Patients with Severe Preeclampsia during Cesarean Delivery: A Pilot Study.

Purpose: Treatment of spinal anesthesia-induced hypotension in patients with severe preeclampsia assumes special concern as hypotension may further reduce placental perfusion. Phenylephrine is still the first-line vasopressor for treating spinal anesthesia-induced hypotension. However, the optimal dose of phenylephrine used as intravenous (IV) boluses in patients with severe preeclampsia has not been clearly determined.

Decomposition analysis of industrial pollutant emissions in cities of Jiangsu based on the LMDI method.

Cities are faced with various kinds of pollution issues in the process of economic development, among which industrial pollution has become the most terrifying environmental issue in recent years, so that industrial pollution control should be emphasized. Finding out the key factors influencing industrial pollutant emissions is the basis of taking corresponding measures. Previous studies only focused on one pollutant without a comparative analysis of the contribution of influencing factors to multiple pollutants.

Rapid BMI Increases and Persistent Obesity in Small-for-Gestational-Age Infants.

In order to compensate for the early intrauterine growth restriction, small-for-gestational age (SGA) infants have "catch-up growth" after birth. Increased caloric intake has been suggested for SGA infants conventionally. It is important to determine if the early growth rate of body mass index (BMI) is associated with risk of persistent obesity later in life.

Long-lasting anti-bacterial activity and bacteriostatic mechanism of tea tree oil adsorbed on the amino-functionalized mesoporous silica-coated by PAA.

Tea tree oil (TTO) is an efficient natural antibacterial agent. However, the bacteriostatic effect of TTO does not prevail for a long period because of the volatile nature of the oil. Therefore, a novel sustained-release formulation of TTO should be developed for improving the applicability of TTO.

Understanding the Capability of an Ecosystem Nature-Restoration in Coal Mined Area.

Ecosystem issues have been severely concerned and studied when the coal resource is one of major energy generators, and green mining innovation techniques involving artificial-restorations have addressed and significantly lessened negative impacts on the ecological environment. The ecosystem of a coal-mined area, however, is able to naturally restore with the processes of natural succession, similar to the human body system that has the immune ability to self-heal a wound over time if the wound does not deeply hurt the health. Here we analyze multiple discipline real data from two mining sites, and evidently show an ability of nature that the coal mining related problems such as geological cracks, damaged aquifers and destroyed soils in Quaternary period can naturally recover around a half-year after the end of mining.

Improving the early screening procedure for autism spectrum disorder in young children: Experience from a community-based model in shanghai.

Most children with autism spectrum disorder (ASD) are not diagnosed until the age of 4, thus missing the opportunity for early intervention. The objective of this study was to investigate the feasibility of an early screening program for ASD applied during well-child visits in a community-based sample. The study lasted for 4 years and was divided into two stages.

[Research on Denoising Ultraviolet Spectrum Signal with An Improved Effective Singular Value Selection Method].

Spectrum denoising is an important part of spectrum detection. As we know, spectral signal is susceptible to thermal noise, mechanical vibration on site and random noise, etc. However, online monitoring systems require to reduce the impact of parameter selection caused by human operation on denoising, so a method based on singular value decomposition is proposed to denoise spectrum signal.

[Studies of the norm and psychometrical properties of the ages and stages questionnaires, third edition, with a Chinese national sample].

Objective: To introduce the Ages and Stages Questionnaires, Third Edition (ASQ-3), to China, created ASQ-Chinese (ASQ-C) and carried out studies of its national norm and the psychometrical properties in the children aged 1-66 months in the mainland of China in collaboration with the author of the ASQ System and under the authorizations from its publisher on translation, researches, publication and distribution of the ASQ-3.

Method: The ASQ-3 questionnaires were translated and adapted into a Simplified Chinese version, the ASQ-C, with six steps such as translation, back-translation and adaptation and so on to ensure consistency with the core of the original document and to have the cultural relevance in China.A stratified cluster sampling method was utilized to recruit children aged 1-66 months with respect to demographic characteristics such as the proportion of population in each administrative region and in urban and rural areas and so on that are representative of 2010 China census data.

[Early warning for various internal faults of GIS based on ultraviolet spectroscopy].

As the basis of accurate diagnosis, fault early-warning of gas insulation switchgear (GIS) focuses on the time-effectiveness and the applicability. It would be significant to research the method of unified early-warning for partial discharge (PD) and overheated faults in GIS. In the present paper, SO2 is proposed as the common and typical by-product.

[An ultraviolet spectroscopy method for rapid partial discharge detection in GIS].

By detecting the stable by-products of SF6 through ultraviolet spectroscopy, the present paper achieved the rapid detection of the GIS partial discharge fault. First derivative and the S-G filter were used for the spectral denoising and smoothing. The discharge experiment was used for validating feature selection.

[Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population].

Objective: In this study, we evaluate the association profiles of the lysyl oxidase-like 1 ( LOXL1) gene polymorphisms with exfoliation syndrome in XFS Uygur population.

Methods: Case-control study. Sixty-four unrelated Uygur patients with XFS (including 7 patients with Exfoliation Syndrome Glaucoma) and 127 Uygur control subjects were included.

Effects of neurotrophin-3 on the differentiation of neural stem cells into neurons and oligodendrocytes.

In this study, cells from the cerebral cortex of fetal rats at pregnant 16 days were harvested and cultured with 20 μg/L neurotrophin-3. After 7 days of culture, immunocytochemical staining showed that, 22.4% of cells were positive for nestin, 10.

[Dimensional accuracy of dental gypsum casts after immersion in stable chlorine dioxide disinfectant].

Objective: To evaluate the changes in dimensional accuracy of dental gypsum casts after immersion in stable chlorine dioxide (SCD) disinfectant solution.

Methods: Each of 90 specimens was made of type III,type IV and type V dental stone, respectively,which were further divided into 9 groups (n=10). The gypsum casts were immersed in 3.

(E)-3-Dimethyl-amino-1-(4-pyrid-yl)prop-2-en-1-one.

The title compound, C(10)H(12)N(2)O, is approximately planar, the r.m.s.

[Analysis on content of Ni-Cr in gingival and blood of hares after wearing non-noble porcelain-fused-to-metal crown].

Objective: Purpose of the study was to investigate the content of Nickel (Ni) and Chromium (Cr) ion in gingival tissue and blood, and to discuss the reason of gray line in gingival after wearing non-noble Porcelain-Fused-to-Metal crown.

Methods: 38 rabbits were selected as experimental animals which were divided into three groups: control group, group 1 (3 months) and group 2 (6 months). The content of Ni and Cr ion in gingival tissue and blood was detected by atomic absorption spectrometer.

[Expression of proliferating cell nuclear antigen/bcl-2 in gray gingival tissue].

Objective: To study the expression of PCNA/bcl-2 protein in gray and normal gingival tissue, and to investigate the biological effect of procelain-fused-to-metals (PFM).

Methods: Gray gingival tissue animal model was established by PFM prosthesis and immunohistochemistry S-P method was used to detect the PCNA/bcl-2 protein expression in gingival tissue after 3 months, 6 months in PFM groups and control group.

Results: The expression of PCNA had significant difference between the 3th month group and the control group (P < 0.