Systemic inflammatory regulators and age-related macular degeneration: a bidirectional Mendelian randomization study.

Introduction: We investigated the relationship between systematic regulators of inflammation and the risk of age-related macular degeneration (AMD), both wet and dry forms, by using bidirectional, two-sample Mendelian randomization (MR).

Methods: We performed bidirectional two-sample Mendelian randomization analysis using genome-wide study (GWAS) data for 91 plasma proteins from 14,824 individuals of European descent across 11 study groups. Next, we utilized data from the FinnGen consortium to study AMD using the inverse- variance-weighted approach for Mendelian randomization.

Safety and Efficacy of a Novel Hemostatic Powder in Total Knee Arthroplasty.

This retrospective study evaluated the safety and efficacy of SURGICEL® Powder-Absorbable Hemostatic Powder (SP) made from oxidized regenerated cellulose (ORC) in total knee arthroplasty (TKA). Ninety-one patients who underwent TKA at Peking University Third Hospital between January 2024 and July 2024 were retrospectively analyzed. Hemostatic effectiveness was evaluated by comparing perioperative blood loss, hemoglobin (Hb) levels, hematocrit (HCT), and transfusion rates.

Cauda equina non-Hodgkin lymphoma and literature review: Report of 2 cases.

Primary non-Hodgkin's lymphoma (NHL) occurring in the cauda equina region within the spinal canal is exceedingly rare. It is characterized by severe clinical symptoms, a high rate of misdiagnosis, rapid progression, poor prognosis, and significant metastasis potential. In this paper, we report 1 case of a 58-year-old female with primary NHL and another case of a 69-year-old male with secondary NHL.

Miniaturized 3D-printed ratiometric electrochemical immunosensing platform for ultrasensitive detection of depression biomarker Apo-A4.

The lack of standardized objective approaches hinders the accurate diagnosis and treatment of depression. Herein, a novel electrochemical platform was created utilizing cost-effective and rapid 3D printing technology to overcome the constraints of conventional diagnostic methods. This method allows for highly sensitive detection of Apolipoprotein A4 (Apo-A4), an important biomarker for depression, using dual-signal outputs.

ISL1 and AQP5 complement each other to enhance gastric cancer cell stemness by regulating CD44 expression.

Background: Gastric cancer, a prevalent and life-threatening malignancy, is believed to involve cancer stem cells (CSCs) as a contributing factor to tumor progression. Insulin gene enhancer binding protein-1 (ISL1) is a transcription factor, and it has not been elucidated how ISL1 regulates gastric carcinogenesis. The aim of this paper is to investigate the role of ISL1 in gastric cancer development.

Strategy on rapid selection of woody species for phytoremediation in soils contaminated with copper, lead and zinc in Shanghai.

The use of woody species for the remediation of heavy metal-contaminated soils is an environmentally friendly and economically viable strategy. This study investigates the phytoextraction abilities of 15 woody species for copper, lead and zinc in contaminated soil. The results indicated that all species showed phytoextraction ability, with metal concentrations varying from 5.

Model analysis and experiment study for effects of thermal viscous and fluid flow on ventilated acoustic metamaterials labyrinth.

In many noise scenarios, ventilation is necessary. The practical realization of noise attenuation under the premise of ensuring ventilation is an urgent problem to be solved. In this paper, a ventilated acoustic metamaterial labyrinth (VAML) is proposed, and the corresponding analytical and numerical computational models are developed considering the thermal viscous effect (TVE).

Is Magnetic Resonance Imaging Able to Provide Specific Diagnoses? A Case Report of Clear Cell Sarcoma of Soft Tissue in the First Metacarpal of the Hand.

Introduction: Clear cell sarcoma (CCS) of the soft tissue is a type of tumor that primarily affects the deep soft tissues of the extremities and trunk. We report a case of CCS of soft tissue arising in the first metacarpal of the hand, focusing on the imaging features of CCS combined with the clinicopathological and immunological results.

Case Presentation: In this case, computed tomography images showed a soft tissue mass at the first metacarpal, with heterogeneous density, unclear boundaries, and bone destruction.

A case report of hepatic subcapsular hematoma: Newborn with an autoimmune hemolytic condition.

We report a case of hepatic subcapsular hematoma in a newborn baby detected with an autoimmune hemolytic condition due to ABO incompatibility. Magnetic resonance imaging could be helpful in differentiating hepatic subcapsular hematoma from other abdominal masses.

Construction of electrochemical immunosensor from MXene/multi-walled carbon nanotubes/gold nanoparticles for specific detection of carcinoembryonic antigen.

With the advancement of nanotechnology, various types of nanomaterials have been integrated into electrochemical immunoelectrodes to enhance their performance. Among these, MXene stands out as a promising candidate due to its high electron transfer capacity and abundant surface chemical groups. However, the improvement in electrode performance is often hindered by the self-restacking and agglomeration of MXene.

NUP37 accumulation mediated by TRIM28 enhances lipid synthesis to accelerate HCC progression.

Elevated intracellular lipid synthesis is important for hepatocellular carcinoma (HCC) progression. Our study aimed to identify the role of nucleoporin 37 (NUP37) in lipid synthesis and HCC progression. The expression of NUP37 was significantly upregulated in HCC and associated with a poor prognosis.

Effect of Selenium and Selenoproteins on Radiation Resistance.

With the advancement of radiological medicine and nuclear industry technology, radiation is increasingly used to diagnose human health disorders. However, large-scale nuclear leakage has heightened concerns about the impact on human organs and tissues. Selenium is an essential trace element that functions in the body mainly in the form of selenoproteins.

Theoretical Analysis of Stacking Fault Energy, Elastic Properties, Electronic Properties, and Work Function of MnCoCrFeNi High-Entropy Alloy.

The effects of different Mn concentrations on the generalized stacking fault energies (GSFE) and elastic properties of MnCoCrFeNi high-entropy alloys (HEAs) have been studied via first-principles, which are based on density functional theory. The relationship of different Mn concentrations with the chemical bond and surface activity of MnCoCrFeNi HEAs are discussed from the perspectives of electronic structure and work function. The results show that the plastic deformation of MnCoCrFeNi HEAs can be controlled via dislocation-mediated slip.

Strengthening mechanism of sub-nano NiP and CuP phases particles on the Pb-Sn bronze alloy.

The influence of the sub-nano NiP and CuP phases on the microstructure, mechanical properties, and strengthening mechanism of Cu-20Pb-5Sn-xP (x = 0,0.05,0.1,0.

Trajectory model to analyze the effect of multi-metal exposures on sperm parameters and sex hormones of the MARHCS cohort in China.

Background: At present, several cross-sectional studies have found that exposure to metal/metalloid elements is closely associated with male reproduction. However, the long-term effects of metal exposure on male reproduction have not been explored.

Methods: In 2013, 796 volunteers were recruited, followed by first and second follow-ups in 2014 and 2015.

Deficiency of SIAH1 promotes the formation of filopodia by increasing the accumulation of FASN in liver cancer.

It has been shown that the formation of filopodia is a key step in tumor cell metastasis, but there is limited research regarding its mechanism. In this study, we demonstrated that fatty acid synthase (FASN) promoted filopodia formation in liver cancer cells by regulating fascin actin-bundling protein 1 (FSCN1), a marker protein for filopodia. Mechanistically, on the one hand, the accumulation of FASN is caused by the enhanced deubiquitination of FASN mediated by UCHL5 (ubiquitin c-terminal hydrolase L5).

Mixture of Synthetic Plant Volatiles Attracts More Stick Tea Thrips Priesner (Thysanoptera: Thripidae) and the Application as an Attractant in Tea Plantations.

The stick tea thrip () is one of the most serious sucking pests of tea plants () in China, North Korea, and Japan. Plant volatile lures are widely used for both monitoring and mass trapping. Previously, we demonstrated that sticky traps baited with -anisaldehyde, eugenol, farnesene, or 3-methyl butanal captured significantly more in tea plantations, with -anisaldehyde notably capturing the most.

DHTPY-Cu@ZOL-Enhanced Photodynamic Therapy: A Strategic Platform for Advanced Treatment of Drug-Resistant Bacterial Wound Infections.

Purpose: This research was to innovate a nanozyme-based therapeutic strategy that combines aggregation-induced emission (AIE) photosensitizers with copper nanozymes. This approach is designed to address the hypoxic conditions often found in bacterial infections and aims to boost the effectiveness of photodynamic therapy (PDT) by ensuring sufficient oxygen supply for reactive oxygen species (ROS) generation.

Methods: Our approach involved the synthesis of dihydroxyl triphenyl vinyl pyridine (DHTPY)-Cu@zoledronic acid (ZOL) nanozyme particles.

Efficacy of the efficacy between dexamethasone versus triamcinolone acetonide after cataract surgery: A systematic review and meta-analysis.

Purpose: To evaluate the clinical effects between dexamethasone and triamcinolone acetonide (TA) after phacoemulsification and intraocular lens implantation among cataract patients.

Methods: Pubmed, Embase, and the Cochrane Library were searched for studies published up to August 2020. The primary outcome was intraocular pressure.

CXCL1/IGHG1 signaling enhances crosstalk between tumor cells and tumor-associated macrophages to promote MC-LR-induced colorectal cancer progression.

Microcystin-leucine arginine (MC-LR) is a common cyantotoxin produced by hazardous cyanobacterial blooms, and eutrophication is increasing the contamination level of MC-LR in drinking water supplies and aquatic foods. MC-LR has been linked to colorectal cancer (CRC) progression associated with tumor microenvironment, however, the underlying mechanism is not clearly understood. In present study, by using GEO, KEGG, GESA and ImmPort database, MC-LR related differentially expressed genes (DEGs) and pathway- and gene set-enrichment analysis were performed.

Correlation Analysis of Digital Mammography, Ultrasonography, and Pathologic Features in Pure Invasive Micropapillary Carcinoma of the Breast (PIMPC).

Purpose: This study determined the digital mammography and ultrasonography imaging features of pure invasive micropapillary carcinoma of the breast (PIMPC) and the correlation with pathologic features.

Patients Methods: Nineteen patients diagnosed with PIMPC at Yantaishan Hospital from October 2015 to February 2022 were included in the study group. Forty patients with breast masses diagnosed as nonspecific invasive ductal carcinoma of the breast (NIDC) from July to December 2021 were included in the control group.