Publications by authors named "Guotu Du"
Article Synopsis
- * The Hippo signaling pathway, crucial for regulating organ size and tissue health, is linked to Yes-associated protein 1 (YAP1), which is found to be overexpressed in bladder cancer and associated with worse outcomes, including tumor recurrence and resistance to treatments.
- * The review focuses on how YAP1 contributes to the onset and progression of bladder cancer, while also exploring its potential role in improving diagnosis and treatment strategies for the disease.
Background: Bladder cancer (BLCA) was recognized as a significant public health challenge due to its high incidence and mortality rates. The influence of molecular subtypes on treatment outcomes was well-acknowledged, necessitating further exploration of their characterization and application. This study was aimed at enhancing the understanding of BLCA by mapping its molecular heterogeneity and developing a robust prognostic model using single-cell and bulk RNA sequencing data.
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