Regulating Manganese-Site Electronic Structure via Reconstituting Nitrogen Coordination for Efficient Non-Oxygen-Dependent Sonocatalytic Therapy against Orthotopic Breast Cancer.

Sonocatalytic therapy (SCT) has emerged as a promising noninvasive modality for tumor treatment but is hindered by the insufficient generation of ultrasound-induced reactive oxygen species (ROS) and the hypoxic tumor microenvironments. Herein, we fabricated a carbon nanoframe-confined N-coordinated manganese single-atom sonocatalyst with a five-coordinated structure (MnN SA/CNF) using a phthalocyanine-mediated pyrolysis strategy. The precise coordination structure was identified by synchrotron X-ray absorption fine structure analyses.

Enhanced OER catalytic activity of single metal atoms supported by the pentagonal NiN monolayer: insight from density functional theory calculations.

Two-dimensional material-supported single metal atom catalysts have been extensively studied and proved effective in electrocatalytic reactions in recent years. In this work, we systematically investigate the OER catalytic properties of single metal atoms supported by the NiN monolayer. Several typical transition metals with high single atom catalytic activity, such as Fe, Co, Ru, Rh, Pd, Ir, and Pt, were selected as catalytic active sites.

A Malicious Code Detection Method Based on Stacked Depthwise Separable Convolutions and Attention Mechanism.

To address the challenges of weak model generalization and limited model capacity adaptation in traditional malware detection methods, this article presents a novel malware detection approach based on stacked depthwise separable convolutions and self-attention, termed CoAtNet. This method combines the strengths of the self-attention module's robust model adaptation and the convolutional networks' powerful generalization abilities. The initial step involves transforming the malicious code into grayscale images.

Precisely modulated 2D PdCu alloy nanodendrites as highly active peroxidase mimics for the elimination of biofilms.

Pd-based nanomaterials are good candidates for antibacterial applications because of their high catalytic activity and good biocompatibility. Nonetheless, there is still much work to do to improve the catalytic activity of Pd nanomaterials as antibacterial agents, particularly for anti-biofilms. In this work, Cu was introduced into Pd to form a series of 2D PdCu alloy nanodendrites (PdCu NDs) as high-performance peroxidase mimics based on flexible control of compositions.

Enhancing anti-tumor effect of ultrasensitive bimetallic RuCu nanoparticles as radiosensitizers with dual enzyme-like activities.

Radiotherapy (RT), through the generation of reactive oxygen species (ROS) and DNA damage to tumor cells caused by high-energy irradiation, has been a widely applied cancer treatment strategy in clinic. However, the therapeutic effect of traditional RT is restricted by the insufficient radiation energy deposition and the side effects on normal tissues. Recently, multifunctional nano-formulations and synergistic therapy has been developed as attractive strategies for used to enhancing the efficacy and safety of RT.

Macrophage-Targeted Sonodynamic/Photothermal Synergistic Therapy for Preventing Atherosclerotic Plaque Progression Using CuS/TiO Heterostructured Nanosheets.

Sonodynamic therapy (SDT) and photothermal therapy (PTT) are two effective strategies for the treatment of atherosclerotic plaques. However, the low yield of reactive oxygen species (ROS) of conventional organic sonosensitizers and the low biosafety of hyperthermia limit the therapeutic efficacy of SDT and PTT. Herein, we report copper sulfide/titanium oxide heterostructure nanosheets modified with hyaluronic acid (HA) and PEG (HA-HNSs) for low-intensity sonodynamic and mild-photothermal synergistic therapy for early atherosclerotic plaques.

Macrophage-Mediated Porous Magnetic Nanoparticles for Multimodal Imaging and Postoperative Photothermal Therapy of Gliomas.

Because of the blood-brain barrier and the high infiltration of glioma cells, the diagnostic accuracy and treatment efficiency of gliomas are still facing challenges. There is an urgent need to explore the integration of diagnostic and therapeutic methods to achieve an accurate diagnosis, guide surgery, and inhibit postoperative recurrence. In this work, we developed a macrophage loaded with a photothermal nanoprobe (MFeO-Cy5.

Photoacoustic and magnetic resonance imaging-based gene and photothermal therapy using mesoporous nanoagents.

The integration of photothermal therapy (PTT) with gene therapy (GT) in a single nanoscale platform demonstrates great potential in cancer therapy. Porous iron oxide nanoagents (PIONs) are widely used as magnetic nanoagents in the drug delivery field and also serve as a photothermal nanoagent for photothermal therapy. However, the therapeutic efficacy of PIONs-mediated GT has not been studied.

Smart Textiles Based on MoS Hollow Nanospheres for Personal Thermal Management.

Two-dimensional transition metal dichalcogenides are of particular interest in high-performance photothermal conversion, yet there remains a huge challenge in their practical application in smart textiles for healthcare, energy, and personal protection. Herein, we controllably prepared MoS hollow nanospheres with a high photothermal conversion efficiency of 36% via a microemulsion-hydrothermal method, which was further applied to construct photothermal fibers for personal thermal management after a hot-blast dip-drying process. Because of the prominent photothermal effect, the temperature of the photothermal fibers sharply increases from the room temperature value of 25.

Size-Dependent Selectivity of Electrochemical CO Reduction on Converted In O Nanocrystals.

The size modulation of catalyst particles represents a useful dimension to tune catalytic performances by impacting not only their surface areas but also local electronic structures. It, however, has remained inadequately explored and poorly elucidated. Here, we report the interesting size-dependent selectivity of electrochemical CO reduction on In O nanocrystals.

Hybridized Mechanical and Solar Energy-Driven Self-Powered Hydrogen Production.

Photoelectrochemical hydrogen generation is a promising approach to address the environmental pollution and energy crisis. In this work, we present a hybridized mechanical and solar energy-driven self-powered hydrogen production system. A rotatory disc-shaped triboelectric nanogenerator was employed to harvest mechanical energy from water and functions as a sufficient external power source.

PbS Quantum Dots/2D Nonlayered CdS Se Nanosheet Hybrid Nanostructure for High-Performance Broadband Photodetectors.

Two-dimensional (2D) nonlayered nanomaterials have attracted extensive attention for electronic and optoelectronic applications recently because of their distinct properties. In this work, we first employed a facile one-step method to synthesize 2D nonlayered cadmium sulfide selenide (CdS Se, x = 0.33) nanosheets with a highly crystalline structure and then we introduced a generic spin-coating approach to fabricate hybrid nanomaterials composed of PbS quantum dots (QDs) and 2D CdS Se nanosheets and demonstrated their potential for high-performance broadband photodetectors.

Synthesis of BiPO4/Bi2S3 Heterojunction with Enhanced Photocatalytic Activity under Visible-Light Irradiation.

BiPO4/Bi2S3 photocatalysts were successfully synthesized by a simple two-step hydrothermal process, which involved the initial formation of BiPO4 rod and then the attachment of Bi2S3 through ion exchange. The as-synthesized products were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and UV-vis diffuse reflectance spectra (UV-vis DRS). It was found that BiPO4 was regular rods with smooth surfaces.

Simple fabrication of N-doped mesoporous TiO2 nanorods with the enhanced visible light photocatalytic activity.

N-doped mesoporous TiO2 nanorods were fabricated by a modified and facile sol-gel approach without any templates. Ammonium nitrate was used as a raw source of N dopants, which could produce a lot of gasses such as N2, NO2, and H2O in the process of heating samples. These gasses were proved to be vitally important to form the special mesoporous structure.