Down-regulation of long non-coding RNA ITGB2-AS1 inhibits osteosarcoma proliferation and metastasis by repressing Wnt/β-catenin signalling and predicts favourable prognosis.

Osteosarcoma is the most common and highly aggressive bone neoplasm often occurs among adolescents and young people. In despite of the major advances in the treatment, the overall survival of osteosarcoma patients remains poor. Long non-coding RNAs (lncRNAs) have been identified as key regulators involved in tumorigenesis and progression of osteosarcoma.

Long noncoding RNA OIP5-AS1 accelerates CDK14 expression to promote osteosarcoma tumorigenesis via targeting miR-223.

The critical roles for long non-coding RNAs (lncRNAs) have been demonstrated for series of cancers, including osteosarcoma. Nevertheless, the accurate mechanism of lncRNAs in osteosarcoma is elusive. In this assay, mechanical researches are performed to investigate the effect and mechanism of lncRNA OIP5-AS1 in osteosarcoma tumorigenesis.

Relationship between sagittal spinal alignment and the incidence of vertebral fracture in menopausal women with osteoporosis: a multicenter longitudinal follow-up study.

Purpose: To investigate the relationship between sagittal spinal alignment and the incidence of vertebral fracture in patients with osteoporosis.

Methods: A cohort of 1,044 postmenopausal women with osteoporosis were prospectively observed for the incidence of lumbar vertebral fracture. Baseline characteristics of the subjects were recorded, including age, year post-menopause, body height and weight, lumbar spine BMD (LSBMD) and femoral neck BMD (FNBMD).

Overexpression of fibroblast activation protein and its clinical implications in patients with osteosarcoma.

Background And Objectives: Fibroblast activation protein (FAP) expression has been detected in fibroblastic component of osteosarcomas. The aim of this study was to analyze the correlation of FAP expression with the clinicopathological features of osteosarcoma.

Methods: FAP mRNA and protein expression levels in human osteosarcoma tissues were, respectively detected by RT-PCR, Western blot, and immunohistochemistry assays.