Dissimilar Gas Tungsten Arc Welding of (FeCoNi)Al High-Entropy Alloy and Q235 Structural Steel.

(FeCoNi)A high-entropy alloy (HEA) is a new material with a strength similar to that of commercial Q235 structural steel, and its elongation is nearly three times greater than that of Q235 steel. Studying the welding process of the (FeCoNi)Al HEA and Q235 steel is expected to further expand the application range of commercial Q235 structural steel and provide a foundation for the engineering application of the (FeCoNi)Al HEA. This study focuses on the dissimilar welded components of (FeCoNi)Al HEA and Q235 steel and analyzes the forming quality, microstructure, and mechanical properties of dissimilar welded samples under different currents.

Effect of Bias Arc on Microstructure and Corrosion Resistance of Q235/304 Dissimilar-Steel-Welded Joints.

To fully exploit the advantages of steel, the welding connection of dissimilar steels has been developed. In this work, the metallographic microstructures, elemental distributions, and electrochemical corrosion properties of the Q235 and 304 welds under different bias arcs were investigated. The arc bias caused the Q235-side heat-affected zone to widen, the microstructure consisted of ferrite and pearlite, and the ratio varied with decreasing distance from the fusion line.

POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6.

POU5F1 plays an important role in maintaining the cancer stem cell (CSC) -like properties of gastric cancer (GC) cells. The impact of POU5F1 on the proliferation and metastasis of GC was examined, along with the potential of ATRA as a specific therapeutic agent for GC. The dysregulation of POU5F1 expression in GC tissues was analyzed using public databases and bioinformatics techniques, and the disparity in POU5F1 expression between normal gastric tissues and GC tissues was further assessed through western blot, RT-qPCR, and immunohistochemistry.

Process Optimization, Microstructure and Mechanical Properties of Wire Arc Additive Manufacturing of Aluminum Alloy by Using DP-GMAW Based on Response Surface Method.

Double-pulsed gas metal arc welding (DP-GMAW) is a high-performance welding method with low porosity and high frequency. Periodic shrinkage and expansion of the melt pool during DP-GMAW leads to unusual remelting, and the re-solidification behavior of the weld metal can significantly refine the weld structure. The advantages of DP-GMAW have been proven.

A clinically applicable prediction model for the risk of in-hospital mortality in solid cancer patients admitted to intensive care units with sepsis.

Purpose: To develop and validate a user-friendly model to predict the risk of in-hospital mortality in solid cancer patients admitted to the ICU with sepsis.

Methods: Clinical data of critically ill patients with solid cancer and sepsis were obtained from Medical Information Mart for Intensive Care-IV database and randomly assigned to the training cohort and validation cohort. The primary outcome was in-hospital mortality.

Upregulation of CRABP2 by TET1-mediated DNA hydroxymethylation attenuates mitochondrial apoptosis and promotes oxaliplatin resistance in gastric cancer.

Oxaliplatin is the main chemotherapy drug for gastric cancer (GC), but quite a few patients are resistant to oxaliplatin, which contributes to the poor prognosis of GC patients. There is therefore an urgent need to identify potential targets for reversing chemotherapy resistance in GC patients. In this study, we analyzed the tumor samples of GC patients who received neoadjuvant chemotherapy based on oxaliplatin through quantitative proteomics and identified the potential chemoresistance-related protein cellular retinoic acid binding protein 2 (CRABP2).

FBXO39 predicts poor prognosis and correlates with tumor progression in cervical squamous cell carcinoma.

Background: Cancer/testis antigen (CTA) is a class of antigen molecules mainly expressed in the germinal epithelium of testis and some tumor tissues. FBXO39, also known as F-box protein 39, is a crucial CTA molecule. F-box protein 39 (FBXO39) is overexpressed in cervical squamous cell carcinomas (CESCs), however its function in cancer development and clinical significance are still unknown.

Cancer stem cells in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is one of the most intractable challenges among human diseases with poor prognosis and shortness of effective therapeutic options. Cancer stem cells (CSCs), a tumor sub-population, are considered the cause of tumor growth, differentiation, metastasis and therapeutic resistance, etc. In this review, we discuss the known methods for isolation and verification of ESCC CSCs, the biomarkers of ESCC CSCs and their significance in diagnosis and prognosis.

NSF-Based Analysis of the Structural Stressing State of Trussed Steel and a Concrete Box Girder.

This paper analyses the characteristics of the mechanical behavior of a trussed steel and concrete box beam under bending conditions based on the structural stressing state theory and the numerical shape function method. Firstly, the parametric generalized strain energy density was introduced to characterize the structural stressing state of trussed steel stud concrete box girders, and the strain energy density sum was plotted. Then the Mann-Kendall criterion was used to discriminate the leap point of the curve change and to redefine the structural failure load.

Stressing State Analysis of Partially Prestressed Concrete Beams with High Strength Reinforcement Based on NSF Method.

This paper analyzes the flexural behavior of a partially prestressed steel high-strength reinforced concrete beams based on the structural stress state theory and the numerical shape function method. First, the generalized strain energy density is formed by the measured strain data of the test beam to reflect the structural stress state of the beams, and then the Mann-Kendall criterion is used to judge characteristic points of the generalized strain energy density curve. Two characteristic points, namely, post-elastic boundary load and failure load, are detected, so that the whole loading process is divided into three structural stressing state stages.

UBQLN4 is activated by C/EBPβ and exerts oncogenic effects on colorectal cancer via the Wnt/β-catenin signaling pathway.

Ubiquilin 4 (UBQLN4) is an important member of the ubiquitin-like protein family. An increasing number of studies have shown that UBQLN4 is an important regulator of tumorigenesis. Nevertheless, the biological function and detailed mechanisms of UBQLN4 in colorectal cancer (CRC) development and progression remain unclear.

Poor histologic tumor response after adjuvant therapy in basal-like HER2-positive breast carcinoma.

Aims: HER2-positive breast carcinomas are all treated with first-line anti-HER2 therapy. However, immunohistochemical and molecular profiling demonstrates significant heterogeneity among HER2-positive carcinomas. Basal-like HER2-positive breast carcinomas are poorly differentiated from pure HER2-positive breast carcinomas.

Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305/TGF-β2/SMAD3 pathway.

Circular RNAs (circRNA) are abundantly present in the exosome. Yet, the role of exosome-transmitted circRNA in colorectal cancer (CRC) remains unclear. In this study, we examined the function and mechanism of circCOG2 in CRC.

Bond Behavior of Reinforced Concrete Considering Freeze-Thaw Cycles and Corrosion of Stirrups.

In relatively cold environments, the combination of freeze-thaw and steel bar corrosion is a key factor affecting the durability of concrete. The adjustment of the stirrup ratio would change the mechanical performance of surrounding concrete, while the circumferential compressive stress can further improve the bonding performance. Hence, based on eccentrically tensioned specimens, the influence of corrosion of stirrups and freeze-thaw of concrete on bond properties is discussed in this paper.

Prognostic Significance of Signet-Ring Cell Components in Patients With Gastric Carcinoma of Different Stages.

Gastric carcinoma (GC), which contains signet ring cell (SRC) components are frequently observed in postoperative pathological assessment. This study aims to study the prognostic significance of SRC components in GC patients. From 2003 to 2017, surgically resected primary GC patients were retrospectively reviewed.

Experimental Investigation on the Static Performance of Stud Connectors in Steel-HSFRC Composite Beams.

In this research, high strength fiber reinforced concrete (HSFRC) was used to replace the normal strength concrete (NSC) in steel-concrete composite beams to improve their working performance, which might change the static performance of stud connectors. Firstly, push-out tests were conducted to investigation on the static performance of stud connectors in steel-HSFRC composite beams and compared with steel-NSC composite beams. Studs of 8 sizes, 13 mm, 16 mm, 19 mm and 22 mm in diameter and 80 mm and 120 mm in height were adopted to study the influence of stud dimension.

Stressing State Analysis of Reinforced Concrete Beam Strengthened by CFRP Sheet with Anchoring Device.

This paper investigates the working performance of reinforcement concrete (RC) beams strengthened by Carbon-Fiber-Reinforced Plastic (CFRP) with different anchoring under bending moment, based on the structural stressing state theory. The measured strain values of concrete and Carbon-Fiber-Reinforced Plastic (CFRP) sheet are modeled as generalized strain energy density (GSED), to characterize the RC beams' stressing state. Then the Mann-Kendall (M-K) criterion is applied to distinguish the characteristic loads of structural stressing state from the curve, updating the definition of structural failure load.

Hsa_circ_0026416 promotes proliferation and migration in colorectal cancer via miR-346/NFIB axis.

Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. Circular RNAs (circRNAs), a novel class of non-coding RNAs, have been confirmed to be key regulators of many diseases. With many scholars devoted to studying the biological function and mechanism of circRNAs, their mysterious veil is gradually being revealed.

Histological Differentiated/Undifferentiated Mixed Type Should Not Be Considered as a Non-Curative Factor of Endoscopic Resection for Patients With Early Gastric Cancer.

Background: Histological differentiated/undifferentiated mixed-type adenocarcinomas are frequently found in patients with early gastric cancer (EGC). Yet it is unclear whether these mixed-type adenocarcinomas can be treated by endoscopic resection (ER) in EGC patients.

Aims: To evaluate the lymph node metastasis (LNM) rate and long-term outcomes in mixed-type EGC patients and assess the feasibility of ER in these patients.

Preservation of the left colic artery and superior rectal artery in laparoscopic surgery can reduce anastomotic leakage in sigmoid colon cancer.

Background: The aim was to study the clinical significance in the preservation of the left colic artery (LCA) and superior rectal artery (SRA) for the laparoscopic resection of sigmoid colon cancer (SCC).

Patients And Methods: A total of 316 patients with SCC were divided into two groups. Group A received D3 resection with preservation of LCA and SRA, whereas Group B ligatured artery at the root of the inferior mesenteric artery.

Primary gastric squamous cell carcinoma presenting as a large submucosal mass: A case report and literature review.

Rationale: Primary gastric squamous cell carcinoma (SCC) is rarely encountered clinically. SCC, which presents as a submucosal tumor, is even rarer. Without the support of pathological evidence, it is difficult to make a correct preoperative diagnosis.

Circular noncoding RNA circMBOAT2 is a novel tumor marker and regulates proliferation/migration by sponging miR-519d-3p in colorectal cancer.

Colorectal cancer (CRC) is a common malignant tumor with a poor prognosis. However, its pathogenesis has not been fully elucidated, accounting for poor overall survival. Circular RNA (circRNA) is a class of noncoding RNAs discovered many years ago.

Total Tumor Volume Should be Considered as an Important Prognostic Factor for Synchronous Multiple Gastric Cancer Patients with Curative Gastrectomy.

Synchronous multiple gastric cancer (SMGC) was a special type of gastric cancer with relatively low incidence. This article was designed to demonstrate that the total tumor volume (TTV) should be treated as an important prognostic factor in SMGC patients with curative gastrectomy. This study retrospective analyzed 140 SMGC patients who received curative gastrectomy between December 2004 and December 2014 in our hospital.

Post-therapy pathologic tumor volume predicts survival in gastric cancer patients who underwent neoadjuvant chemotherapy and gastrectomy.

Background: To demonstrate that post-therapy pathological tumor volume (ypTV) should be considered as an independent prognostic factor in advanced gastric cancer (GC) patients who underwent neoadjuvant chemotherapy (NAC) and gastrectomy.

Methods: A total of 253 GC patients who received gastrectomy between January 2010 and December 2016 in our hospital were enrolled in this study. Clinicopathologic factors were evaluated using univariable and multivariable analysis.

The prognostic value of immunoscore in patients with colorectal cancer: A systematic review and meta-analysis.

The tumor immune infiltrate, as recently evaluated with the immunoscore methodology, has been reported to be related to colorectal cancer (CRC) progression. Nevertheless, results varied from different studies. A meta-analysis was conducted to solve this problem.