Association between sleep patterns and galectin-3 in a Chinese community population.

Background: Irregular sleep patterns have been associated with inflammation. Galectin-3, a novel biomarker, plays an important role in inflammation. We investigated the relationship between sleep patterns and galectin-3 in a Chinese population.

Effective evaluation of HGcnMLP method for markerless 3D pose estimation of musculoskeletal diseases patients based on smartphone monocular video.

Markerless pose estimation based on computer vision provides a simpler and cheaper alternative to human motion capture, with great potential for clinical diagnosis and remote rehabilitation assessment. Currently, the markerless 3D pose estimation is mainly based on multi-view technology, while the more promising single-view technology has defects such as low accuracy and reliability, which seriously limits clinical application. This study proposes a high-resolution graph convolutional multilayer perception (HGcnMLP) human 3D pose estimation framework for smartphone monocular videos and estimates 15 healthy adults and 12 patients with musculoskeletal disorders (sarcopenia and osteoarthritis) gait spatiotemporal, knee angle, and center-of-mass (COM) velocity parameters, etc.

A Precise Hip Protection System with Multi-scale Fall Warning Algorithm Based on Offset Displacement.

Falls occur frequently in daily life and the damage to the body is irreversible. Therefore, it is crucial to implement timely and effective warning and protection systems for falls to minimize the damage caused by falls. Currently, the fall warning algorithm has shortcomings such as low recognition rates for falls and fall-risk movements and insufficient lead-time, the time before the subject impacts the floor, making it difficult for falling protection devices to function effectively.

Impact of healthy lifestyles on risk of hypertension in the Chinese population: finding from SHUN-CVD study.

Introduction: Lifestyle factors are known to play a role in the development of hypertension. We aimed to study the relationship between lifestyle and hypertension in a Chinese population.

Methods: This study involved 3,329 participants (1,463 men and 1,866 women) aged 18-96 years in the Shenzhen-Hong Kong United Network on Cardiovascular Disease.

Association of beta-2-microglobulin, cystatin C and lipocalin-2 with stroke risk in the general Chinese population.

Introduction: Beta-2-microglobulin (B2M), cystatin C and lipocalin-2 (LCN-2) are established renal biomarkers, yet their roles in stroke have not been fully evaluated. We aimed to investigate the relationship of B2M, cystatin C, and LCN-2 with stroke risk in a general Chinese population.

Methods: We used ordinal regression to study the relationship between serum B2M, cystatin C, and LCN-2 with stroke risk in 1060 participants (mean age 45.

A fuzzy granular logistic regression algorithm for sEMG-based cross-individual prosthetic hand gesture classification.

Prosthetic systems are used to improve the quality of life of post-amputation patients, and research on surface electromyography (sEMG)-based gesture classification has yielded rich results. Nonetheless, current gesture classification algorithms focus on the same subject, and cross-individual classification studies that overcome physiological factors are relatively scarce, resulting in a high abandonment rate for clinical prosthetic systems. The purpose of this research is to propose an algorithm that can significantly improve the accuracy of gesture classification across individuals.

The reliability and validity of gait analysis system using 3D markerless pose estimation algorithms.

Quantifying kinematic gait for elderly people is a key factor for consideration in evaluating their overall health. However, gait analysis is often performed in the laboratory using optical sensors combined with reflective markers, which may delay the detection of health problems. This study aims to develop a 3D markerless pose estimation system using OpenPose and 3DPoseNet algorithms.

Association of waist circumference with haemoglobin A1c and its optimal cutoff for identifying prediabetes and diabetes risk in the Chinese population.

Haemoglobin A1c (HbA1c) is a marker of glycaemic control in type 2 diabetes mellitus (T2DM). Increased waist circumference (WC) is known to be associated with T2DM. Therefore, we investigated the relationship of WC with HbA1c and explored its optimal cutoff for identifying prediabetes and diabetes risk.

A Portable Wearable Inertial System for Rehabilitation Monitoring and Evaluation of Patients With Total Knee Replacement.

Knee osteoarthritis is a degenerative disease, which greatly affects the daily life of patients. Total knee replacement (TKR) is the most common method to treat knee joint disorders and relieve knee pain. Postoperative rehabilitation exercise is the key to restore knee joint function.

Automatic Fall Protection for Hips Based on Micromechanical Double Gas Cylinder Rapid Puncture and Bionic Capsule Inflation.

Wearable hip-protection airbags can effectively protect hip joints when elderly people fall. This has been studied all over the world, but similar products need to use special gas cylinders and replacement of new gas cylinders needs to return to the factory; The team previously designed a mechanical puncture protection system based on standard gas cylinders and standard threaded interfaces, but the airbag still has shortcomings such as the small protective area caused by a single gas cylinder. To solve the above problems, a set of wearable hip automatic protection systems based on micromechanical double gas cylinder rapid puncture (MDGCRP) is now designed.

Design of an Unpowered Ankle-Foot Exoskeleton Used for Walking Assistance.

Enhance human walking and running is much more difficult compared to build a machine to help someone with disability. Unpowered ankle-foot exoskeletons are the current development trend due to their lightweight, wearable, and energy-free features, but the huge recognition and energy control system still affects their practicability. To refine the recognition and control system, we designed an unpowered soft ankle-foot exoskeleton with a purely mechanical self-adaptiveness clutch, which can realize the collection and release of energy according to different gait stage.

3D Bioprinting of shear-thinning hybrid bioinks with excellent bioactivity derived from gellan/alginate and thixotropic magnesium phosphate-based gels.

3D Bioprinting is expected to become a strong tool for regenerative medicine, but satisfactory bioinks for the printing of constructs containing living cells are lacking due to the rigorous requirement of high printability and biocompatibility, which are often contradictory. Here, we have reported the development of a novel hybrid bioink by combining rigid gellan gum (GG), flexible sodium alginate (SA), and a bioactive substance thixotropic magnesium phosphate-based gel (TMP-BG). The ratio of these components was first optimized to obtain satisfactory gelating, mechanical, rheological, and printing properties.

Correction to: An explorative investigation of functional differences in plantar center of pressure of four foot types using sample entropy method.

In the original publication of the article the affiliation of Kamen Ivanov was inaccurate. The correct affiliation of Kamen Ivanov is given below.

Targeted next-generation sequencing approach for molecular genetic diagnosis of hereditary colorectal cancer: Identification of a novel single nucleotide germline insertion in adenomatous polyposis coli gene causes familial adenomatous polyposis.

Background: Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disease which primarily manifested with developing adenomas or polyps in colon or rectum. It is caused by the germline mutations in adenomatous polyposis coli (APC) gene. Patients with FAP are usually manifested with "hundreds or even thousands" adenomas or polyps in colon or rectum.

Real-time Action Recognition and Fall Detection Based on Smartphone.

This paper presents a smartphone application which has realized action recognition and fall detection. The application identifies the holding pattern of smartphone by the data of light sensor, distance sensor and accelerometer sensor, which reduce the impact of recognition resulting from the smartphone's different positions. And then the application uses data collected from the acceleration sensor, the direction angle sensor and the gyro sensor to distinguish fall from daily actions.

Pre-impact Alarm System for Fall Detection Using MEMS Sensors and HMM-based SVM Classifier.

Accidental fall can cause physical injury, fracture and other health complication, especially for elderly people living alone. Aimed to provide timely assistance after the occurrence of falling down, a pre-fall alarm system was proposed. In order to test the reliability of pre-fall alarm system, eighteen subjects who worn this device on the waist were required to participate in a series of experiments.

Photopatternable Magnetic Hollowbots by Nd-Fe-B Nanocomposite for Potential Targeted Drug Delivery Applications.

In contrast to traditional drug administration, targeted drug delivery can prolong, localize, target and have a protected drug interaction with the diseased tissue. Drug delivery carriers, such as polymeric micelles, liposomes, dendrimers, nanotubes, and so on, are hard to scale-up, costly, and have short shelf life. Here we show the novel fabrication and characterization of photopatternable magnetic hollow microrobots that can potentially be utilized in microfluidics and drug delivery applications.

A novel thixotropic magnesium phosphate-based bioink with excellent printability for application in 3D printing.

The emergence of 3D bioprinting is expected to solve the present puzzle in the field of regenerative medicine. However, the appropriate bioink was lacking due to the rigorous requirement of high printability and biocompatibility, which was often contradictory. In this study, a novel thixotropic magnesium phosphate-based gel (TMP-BG) was prepared and its application in 3D printing was explored.

A wearable action recognition system based on acceleration and attitude angles using real-time detection algorithm.

Falls are a main cause of trauma and death. The purpose of this study is to adopt unique resultant acceleration and attitude angles to distinguish falls from activities of daily life before impact. In this study, we developed a wearable action recognition system to acquire action data.

A MAC protocol with high scalability for motion capture based on frequency division multiple and time division multiple access.

A good performance of motion capture, which belongs to body sensor network, depends on a reasonable design of MAC protocol. The purpose of this study is to design a reliable and highly extensible protocol for applying in motion capture. The proposed MAC protocol can easily be actualized by the timer in the chip.

A novel pathogenic single nucleotide germline deletion in APC gene in a four generation Chinese family with familial adenomatous polyposis.

Familial adenomatous polyposis (FAP) is an autosomal dominant precancerous condition which is associated with germline mutations of the APC gene. Clinically, FAP is characterized by the development of multiple colorectal adenomas or polyps which finally result in colorectal cancer by the 40 years age of the patient, if no surgical interventions have been undertaken. In this study, we present a clinical molecular study of a four generation Chinese family with FAP.

A novel pathogenic splice acceptor site germline mutation in intron 14 of the APC gene in a Chinese family with familial adenomatous polyposis.

Familial adenomatous polyposis (FAP) is an autosomal dominant precancerous condition, clinically characterized by the presence of multiple colorectal adenomas or polyps. Patients with FAP has a high risk of developing colorectal cancer (CRC) from these colorectal adenomatous polyps by the mean age of diagnosis at 40 years. Germline mutations of the APC gene cause familial adenomatous polyposis (FAP).