Publications by authors named "Guoru Yang"
Objectives: This study aimed to evaluate the therapeutic effect of suraxavir marboxil (GP681, abbreviated as suraxavir) in adults with uncomplicated influenza.
Methods: We conducted a multi-centre randomized, double-blind, placebo-controlled phase 2 trial in 18 Chinese centres. Participants had to be aged 18 to 65 years with a positive influenza test, presenting with at least one influenza systemic and respiratory symptom in at least moderate severity within 48 hours of onset.
Suraxavir marboxil (GP681) is an antiviral drug inhibiting the polymerase acidic protein (PA) of RNA polymerase, of influenza. It has shown therapeutic activity against influenza A and B virus infections in preclinical studies. In this multicenter randomized, double-blind, placebo-controlled, phase 3 trial, we aimed to investigate the efficacy and safety of single-dose suraxavir marboxil (40-mg oral dose) in otherwise healthy outpatients aged 5-65 years with uncomplicated influenza unaccompanied by severe issues.
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- The study investigates how Mycobacterium tuberculosis spreads and migrates within China by analyzing a large dataset of tuberculosis strain genomes.
- It found that lineage 2 (L2), especially sublineage 2.2.1, is the most prevalent and has higher transmissibility compared to other strains, showing significant cross-regional spread.
- The research highlights the public health implications of the L2.2.1 strain, as it poses a considerable challenge to tuberculosis control efforts in the country.
Background: A large proportion of pulmonary embolism (PE) heritability remains unexplained, particularly among the East Asian (EAS) population. Our study aims to expand the genetic architecture of PE and reveal more genetic determinants in Han Chinese.
Methods: We conducted the first genome-wide association study (GWAS) of PE in Han Chinese, then performed the GWAS meta-analysis based on the discovery and replication stages.
Patients with interstitial lung disease (ILD) who subsequently develop a viral infection have high rates of morbidity and mortality. Few large-scale epidemiological studies have investigated potential prognostic factors for morbidity and mortality in this patient group. To evaluate the risk factors for morbidity and mortality in hospitalized patients with ILD and viral infection, as well as the clinical characteristics.
View Article and Find Full Text PDFProbe A shown in the GeneXpert MTB/RIF assay during the detection of Mycobacterium intracellular infections.
Diagn Microbiol Infect Dis
February 2021
Mycobacterium tuberculosis (MTB) is commonly diagnosed via the GeneXpert MTB/RIF assay. The cycle threshold (Ct) value of probe A from this assay produced a fluorescence signal upon Mycobacterium intracellulare detection. No other nontuberculous mycobacteria (NTM) exhibited positive probe signals.
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- The study investigates the role of non-influenza respiratory viruses in community-acquired pneumonia (CAP) among hospitalized immunocompetent adults in China and finds that they contribute significantly to viral pneumonia cases.
- Out of 2336 adult patients with viral infections, 915 were analyzed, revealing that 28.4% were due to influenza virus, while non-influenza viruses comprised 27.4%, with adenovirus linked to more severe symptoms.
- The complications and clinical outcomes for patients with non-influenza viral infections were found to be similar to those with influenza virus infections, suggesting that non-influenza viruses also pose a notable risk in pneumonia cases.
Article Synopsis
- A study was conducted on the relationship between air pollution and the risk of pulmonary tuberculosis (TB) among 9,344 patients in Jinan, China, from 2011 to 2015.
- Researchers analyzed various air pollutants, including particulate matter (PM) and carbon monoxide (CO), and assessed their impact over multiple time frames (3, 6, 9, and 12 months) prior to TB diagnosis.
- While overall findings didn't strongly link air pollution to TB risks, significant associations were found specifically with PM and CO when looking at 3- and 9-month exposure windows, particularly in male and female patients under 60.
The emergence and spread of drug-resistant tuberculosis (DR-TB) has become the major concern in global TB control nowadays due to its limited therapy options and high mortality. A comprehensive evaluation for the epidemiological trends of DR-TB in mainland China, of which TB incidences remain high, is essential but lacking. This study aimed to describe the trends of DR-TB overtime, especially multidrug-resistant TB (MDR-TB); and to identify unique characteristics of MDR-TB cases compared with drug-susceptible TB cases in Mainland China.
View Article and Find Full Text PDFBackground: Relatively little is known about the specific relationship and impact from chronic obstructive pulmonary disease (COPD) on multidrug-resistant tuberculsosis (MDR-TB).
Methods: We conducted a retrospective study included patients aged ≥40 years with a confirmed pulmonary TB at three tertiary hospitals (Shandong, China) between January 2011 and October 2014. Univariable and multivariable analyses were performed to identify the relationship of MDR-TB and COPD.
Objective: The relationship between extensively drug-resistant tuberculosis (XDR-TB) and multidrug-resistant Gram-negative bacilli (MDR-GNB) is unclear. Identification of the relationship between XDR-TB and MDR-GNB would have important implications for patient care.
Methods: We conducted a retrospective study reviewing the records of patients admitted with a confirmed pulmonary TB from 2011 to 2014.