Circular RNA 14580 promotes papillary thyroid cancer progression by interacting with CTSW/fibrosis singling pathway.

Papillary thyroid cancer (PTC) is an increasingly prevalent endocrine malignancy, with a subset exhibiting aggressive features such as lymphatic metastasis and resistance to iodine therapy. Recent studies suggest that circular RNAs (circRNAs) play a significant role in PTC pathology. High throughput circRNA sequencing identified circRNA_14580 as notably upregulated in PTC tissues.

Fused Triazole-Tetrazine Assembled with Different Functional Moieties: Construction of Multipurpose Energetic Materials.

Azido, amino, and azo functionalities were introduced into tetrazine backbones to access multifunctional energetic materials. demonstrates effective initiation capability (MPC = 50 mg), whereas balances well between the energy and stability. Azo-functionalized has a high density of 1.

A three-dimensional energetic coordination compound (BLG-1) with excellent initiating ability for lead-free primary explosives.

Exploration of advanced lead-free primary explosives is a challenging issue in the field of energetic materials. Herein, we designed and synthesized a novel N-rich copper bromate energetic coordination compound (ECC) [Cu(ATRZ)(BrO)] (BLG-1, ATRZ: 4,4'-azo-1,2,4-triazole) by a simple one-step reaction. BLG-1 is the first reported three-dimensional (3D) N-rich copper bromate ECC.

A Highly Effective Liquid-Solid Reaction for In Situ Preparation of Copper Azide.

Copper azide (CA) is a promising energetic material with characteristics of high energy output and environmental friendliness that can be used as a microinitiator charge, but the extreme sensitivities hinder its practical applications. In situ preparation of CA can avoiding operating on sensitive CA directly and depressed the risk of handling. However, it is still a challenge to develop a straightforward, high-efficiency in situ preparation method.

High-Energy Metal-Organic Frameworks with a Dicyanamide Linker for Hypergolic Fuels.

In this study, a hypergolic linker (dicyanamide, DCA) and a high-energy nitrogen-rich ligand (1,5-diaminotetrazole, DAT) were applied to construct high-energy metal-organic frameworks (HEMOFs) with hypergolic property. Three novel metal-organic frameworks (MOFs) were synthesized via a mild method with fascinating 2D polymeric architectures, and they could ignite spontaneously upon contact with white fuming nitric acid (WFNA). The gravimetric energy densities of the three HEMOFs all exceeded 26.