Publications by authors named "Guoqing Hong"
HMGB1/TREM1 crosstalk between heat-injured hepatocytes and macrophages promotes HCC progression after RFA.
J Cancer Res Clin Oncol
October 2024
Article Synopsis
- The study investigates how tumor recurrence after radiofrequency ablation (RFA) affects survival rates in liver cancer patients and seeks to understand the role of thermal injury on hepatocytes (HCs).
- A mouse model was created to analyze the impact of RFA-induced thermal injury on HCs and the surrounding immune response, finding that damaged HCs release HMGB1, which contributes to an immunosuppressive environment and promotes liver cancer cell invasion.
- The research suggests that targeting HMGB1 could be a potential strategy to reduce liver cancer recurrence following thermal ablation treatments.
Article Synopsis
- Cancer-associated fibroblasts (CAFs) contribute significantly to tumor behavior in kidney cancer but their specific functions in Kidney Renal Clear Cell Carcinoma (KIRC) are not well-defined.
- A prognostic model using 6 specificCAF genes was created, predicting patient outcomes and showing that high-risk patients had worse survival rates.
- Elevated PGF levels in tumor tissues were linked to increased cell proliferation and migration, suggesting PGF could be a potential target for KIRC therapy.
Article Synopsis
- High-intensity focused ultrasound (HIFU) is commonly used for treating liver cancer, but its effectiveness is limited by sound energy attenuation when ultrasound penetrates deep liver tissues, resulting in increased tumor recurrence risk.
- * Researchers developed cationic microbubbles (CMB) that are linked to specific genes (GPC3 and HSV-TK plasmids) to target and bind with liver cancer cells, enhancing treatment precision.
- * The combination of these targeted microbubbles with HIFU resulted in high gene transfection efficiency, effectively inhibiting liver cancer cell growth and improving the overall treatment outcome for liver cancer.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a severe type of liver cancer with a poor outlook, and long noncoding RNAs (lncRNAs) like INKA2-AS1 might play a key role in its development and serve as biomarkers for diagnosis and treatment.
- Research showed that INKA2-AS1 is significantly overexpressed in HCC tissues compared to normal tissues, with a strong association to shorter overall and disease-specific survival rates for patients with high INKA2-AS1 levels.
- The study also revealed correlations between INKA2-AS1 expression and various immune cell types, indicating its potential as an independent prognostic factor for HCC and a candidate for further cancer research.
Article Synopsis
- - Researchers studied gene expressions in hepatocellular carcinoma (HCC) using TCGA datasets to create a gene signature related to clinical stages of the disease, identifying 21 differentially expressed genes (DEGs) between early (I-II) and advanced (III-IV) stages.
- - They developed a new seven-gene signature (PITX2, PNCK, GLIS1, SCNN1G, MMP1, ZNF488, and SHISA9) that can independently predict overall survival in HCC patients, validated through survival and ROC analysis.
- - The study found that patients with a low risk score had higher immune activity, and confirmed that silencing the PNCK gene decreased HCC cell growth
Article Synopsis
- Long-term survival rates for patients with hepatocellular carcinoma (HCC) are poor due to ongoing cancer development, prompting research into gene signatures as prognosis indicators.
- The study analyzed data from TCGA to find 280 genes with altered expression related to survival, highlighting three crucial genes (FCN3, CDC20, and E2F1) linked to better long-term outcomes.
- A prognostic model was developed using CDC20 and FCN3, finding that high-risk patients had shorter survival times, while also discovering connections between risk scores and immune cell infiltration in HCC, suggesting potential for targeted therapy.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a type of cancer that is influenced by immune cells like dendritic cells, macrophages, and natural killer cells, which contribute to the inflammatory environment surrounding the tumor.
- The interactions between these innate immune cells and T cells are crucial for understanding how they might affect HCC and why current immunotherapies have limited effectiveness.
- The review highlights the roles of various innate immune cells in HCC and emphasizes the need for more research to improve immunotherapy strategies by focusing on the communication between innate and adaptive immune responses.
Article Synopsis
- - The study aimed to explore how endoplasmic reticulum (ER) stress in Kupffer cells (KCs) and their production of tumor necrosis factor (TNF) contribute to the apoptosis of hepatic stellate cells (HSCs) in rats.
- - Sixty male SD rats were divided into five groups and treated with various substances to induce liver stress and assess liver function, fibrosis, and inflammatory markers through multiple laboratory techniques.
- - Results indicated that rats in the model group had worsened liver conditions compared to the control group, while those with induced ER stress showed improvement in liver function and reduced activation of HSCs, suggesting a protective role of KCs under stress.