Fine mapping of a major QTL, qECQ8, for rice taste quality.

Background: Rice ECQ (eating and cooking quality) is an important determinant of rice consumption and market expansion. Therefore, improvement of ECQ is one of the primary goals in rice breeding. However, ECQ-related quantitative trait loci (QTL) have not yet been fully revealed.

Root physiological and soil microbial mechanisms underlying responses to nitrogen deficiency and compensation in Indica and Japonica rice.

Compensatory effects are common biological phenomena in nature. In this study, we investigated the changes in root nitrogen uptake, root morphological and physiological responses, and changes in the rhizosphere soil microbial communities of indica and japonica rice during a nitrogen deficiency-sensitive period and an effective compensation period with double the nitrogen supply. We conducted a bucket experiment using Suxiu 867 (a japonica rice variety) and Yangxian You 918 (an indica rice variety).

Wild species rice -mediated arbuscular mycorrhiza symbiosis boosts yield and nutrient use efficiency in rice breeding.

Unlabelled: Meeting the ever-increasing food demands of a growing global population while ensuring resource and environmental sustainability presents significant challenges for agriculture worldwide. Arbuscular mycorrhizal symbiosis (AMS) has emerged as a potential solution by increasing the surface area of a plant's root system and enhancing the absorption of phosphorus, nitrogen nutrients, and water. Consequently, there is a longstanding hypothesis that rice varieties exhibiting more efficient AMS could yield higher outputs at reduced input costs, paving the way for the development of Green Super Rice (GSR).

Epigenome-wide methylation haplotype association analysis identified HLA-DRB1, HLA-DRB5 and HLA-DQB1 as risk factors for rheumatoid arthritis.

The aim of this study was to compare nonrandom associations between physically adjacent single methylation polymorphism loci among rheumatoid arthritis (RA) and normal subjects for investigating RA-risk methylation haplotypes (meplotype). With 354 ACPA-positive RA patients and 335 normal controls selected from a case-control study based on Swedish population, we conducted the first RA epigenome-wide meplotype association study using our software EWAS2.0, mainly including (i) converted the β value to methylation genotype (menotype) data, (ii) identified methylation disequilibrium (MD) block, (iii) calculated frequent of each meplotypes in MD block and performed case-control association test and (iv) screened for RA-risk meplotypes by odd ratio (OR) and p-values.

[Research on Management Efficiency of Hospital Low-value Consumables in Nursing Unit under Lean Management Mode].

Aiming at the management efficiency problems in the traditional medical low-value consumables management mode of the nursing unit, based on the perspective of supply chain management, this study uses lean management method to construct the lean management mode of low-value consumables with a whole cycle and whole process information monitoring, and analyzes the application effect of this mode. The results show that after the application of lean management mode, the low-value consumables of the nursing unit can achieve "consumables in use=priced consumables + un-priced consumables", the settlement cost is significantly reduced and its stability is high, and the efficiency of "supply-inventor-distribution" link is significantly enhanced. This model effectively improves the management efficiency of low-value consumables in the hospital, and also provides a reference for other hospitals to improve the management level of low-value consumables.

Integrated 16S and metabolomics revealed the mechanism of drought resistance and nitrogen uptake in rice at the heading stage under different nitrogen levels.

The normal methods of agricultural production worldwide have been strongly affected by the frequent occurrence of drought. Rice rhizosphere microorganisms have been significantly affected by drought stress. To provide a hypothetical basis for improving the drought resistance and N utilization efficiency of rice, the study adopted a barrel planting method at the heading stage, treating rice with no drought or drought stress and three different nitrogen (N) levels.

Transcriptome and Metabolome Analysis Provides Insights into the Heterosis of Yield and Quality Traits in Two Hybrid Rice Varieties ( L.).

Heterosis is a common biological phenomenon that is useful for breeding superior lines. Using heterosis to increase the yield and quality of crops is one of the main achievements of modern agricultural science. In this study, we analysed the transcriptome and metabolome of two three-line hybrid rice varieties, Taiyou 871 (TY871), and Taiyou 398 (TY398) and the parental grain endosperm using RNA-seq (three biological repeats per variety) and untargeted metabolomic (six biological repeats per variety) methods.

Identification of novel meQTLs strongly associated with rheumatoid arthritis by large-scale epigenome-wide analysis.

Rheumatoid arthritis (RA) is highly heritable, and previous studies have suggested that genetic variation may affect susceptibility to RA by altering epigenetic modifications (e.g. DNA methylation).

RABC: Rheumatoid Arthritis Bioinformatics Center.

Advances in sequencing technologies have led to the rapid growth of multi-omics data on rheumatoid arthritis (RA). However, a comprehensive database that systematically collects and classifies the scattered data is still lacking. Here, we developed the Rheumatoid Arthritis Bioinformatics Center (RABC, http://www.

Mobile-Based and Self-Service Tool (iPed) to Collect, Manage, and Visualize Pedigree Data: Development Study.

Background: Pedigree data (family history) are indispensable for genetics studies and the assessment of individuals' disease susceptibility. With the popularity of genetics testing, the collection of pedigree data is becoming more common. However, it can be time-consuming, laborious, and tedious for clinicians to investigate all pedigree data for each patient.

[Practice of Refined Management of Diagnostic Reagents Based on SPD in Hospital].

The management of diagnostic reagents has always been a concern. This paper describes the application of SPD medical consumables fine management system in our hospital. Relying on the brand-new management mode, the whole process from supplier qualification certificate management, diagnostic reagent procurement management, secondary warehouse management, and then to the use process traceability was realized.

The regular pattern and underlying mechanisms of seawater intrusion in the Modaomen channel in the Pearl River Estuary of China.

In recent decades, the frequency and severity of inland river seawater intrusion has increased in the Pearl River Estuary (PRE) of China. Based on time series of water salinity data, river discharges, tides, and wind records for the period 2003-2015, this study aims to examine the regular pattern and underlying mechanisms of the seawater intrusion in the Modaomen channel of the PRE. Toward this end, the autocorrelation and spectral analysis are used to quantify the periodicity of runoff, tide, and water salinity and to infer the regular patterns of seawater intrusion.

Unraveling the relative impacts of climate change and human activities on grassland productivity in Central Asia over last three decades.

Climate change (CC) and human activities (HA) have severely influenced grassland productivity in Central Asia since the 1980s. However, the relative impacts of CC and HA on grassland productivity are not adequately documented, especially over the past three decades. In this study, we adapted the Ensemble Empirical Mode Decomposition (EEMD) to reveal potential timescales at which grassland productivity varied in Central Asia and to investigate the spatiotemporal variations of grassland productivity during 1982-2015.

[Construction of Quality Control System for Medical Equipment under the Model of County Medical Service Community].

The construction of county and district medical community is an important measure for high-quality medical resources to "double sink and improve". In this study, we have initially constructed a medical equipment quality control system for members of the regional medical community. The current situation of lack of professional medical equipment management personnel and quality control equipment in primary medical institutions has been alleviated, the quality control level of medical equipment in primary medical institutions has been improved, and a new management model for quality control of primary medical equipment has been explored.

A Comparison of Co-methylation Relationships Between Rheumatoid Arthritis and Parkinson's Disease.

Rheumatoid arthritis (RA) is a complex autoimmune disease. Recent studies have identified the DNA methylation loci associated with RA and found that DNA methylation was a potential mediator of genetic risk. Parkinson's disease (PD) is a common neurodegenerative disease.

The variation of vegetation greenness and underlying mechanisms in Guangdong province of China during 2001-2013 based on MODIS data.

This study explored the spatiotemporal variation of vegetation greenness and the mechanisms underlying this variation in the subtropical region of Guangdong in China during 2001-2013 to obtain a better understanding of vegetation response to climate and land use/cover changes in warm-humid regions. Satellite-based vegetation indices, land use/cover data and observed weather records during 2001-2013 were used. Univariate and multivariate linear regressions were conducted to quantify the trends and variations in vegetation greenness and the relationships with climate and land use/cover changes.

EWASdb: epigenome-wide association study database.

DNA methylation, the most intensively studied epigenetic modification, plays an important role in understanding the molecular basis of diseases. Furthermore, epigenome-wide association study (EWAS) provides a systematic approach to identify epigenetic variants underlying common diseases/phenotypes. However, there is no comprehensive database to archive the results of EWASs.

Response to Nitrogen Deficiency and Compensation on Physiological Characteristics, Yield Formation, and Nitrogen Utilization of Rice.

Based on the theory of ecological crop nutrient deficiency and compensation effect, the nitrogen (N) deficiency at tillering stage and N compensation at young panicle differentiation stage in rice ( L.) was selected to study. Four N treatments were treated, and the effects of N deficiency and compensation were investigated on grain yield, N uptake and utilization and the physiological characteristics of rice.

[The Traceability Management for Qualification Documents of Medical Instruments].

The management for qualification documents of medical instruments is very important work to management department of medical instruments. Because the number of qualification documents of medical instruments is very large and they have an expiry date, it is difficult to manage them. This article discussed how to manage qualification documents of medical instruments, and an information management system that has a function of traceability management has been developed.

[Refined Management of the Second Class Warehouse and Cost-benefit Analysis for In-vitro Diagnostic Reagent].

As the material basis of clinical examination, in -vitro diagnostic reagent could directly affect the timeliness and accuracy of clinical examination report if it was not uses properly. This article discusses about how to strengthen the management for the temperature monitoring, effect management, inventory management and cost-benefit analysis of in-vitro diagnostic reagents. An information management system that provides methods for fine management of in-vitro diagnostic reagents has been developed.

[A Medical Devices Management Information System Supporting Full Life-Cycle Process Management].

Medical equipments are essential supplies to carry out medical work. How to ensure the safety and reliability of the medical equipments in diagnosis, and reduce procurement and maintenance costs is a topic of concern to everyone. In this paper, product lifecycle management (PLM) and enterprise resource planning (ERP) are cited to establish a lifecycle management information system.

The management in response to marine oil spill from ships in China: A systematic review.

Historical trends about marine ship-source oil spill incidents from 1990 to 2010 in China were analyzed, and it provided an overview of the status quo of China's management in response to marine oil spill from ships. The Chinese government has issued a series of laws on marine environmental protection since 1982, and promulgated many regulations to prevent and tackle ship-source oil spill. At present, the oil spill emergency response system established in China has five levels: the national level, sea level, provincial level, port level, and ship level.

[A medical consumable material management information system].

Medical consumables material is essential supplies to carry out medical work, which has a wide range of varieties and a large amount of usage. How to manage it feasibly and efficiently that has been a topic of concern to everyone. This article discussed about how to design a medical consumable material management information system that has a set of standardized processes, bring together medical supplies administrator, suppliers and clinical departments.

RADB: a database of rheumatoid arthritis-related polymorphisms.

Rheumatoid arthritis (RA) is an autoimmune disease that has a complex genetic basis. Therefore, it is important to explore the genetic background of RA. The extensive recent application of polymorphic genetic markers, especially single nucleotide polymorphisms, has presented us with a large quantity of genetic data.

[PTPN22 1858C/T polymorphism is associated with rheumatoid arthritis susceptibility in Caucasian population: a meta-analysis].

Objective: To investigate the association of 1858C/T polymorphism of protein tyrosine phosphatase nonreceptor type 22 (PTPN22) and rheumatoid arthritis (RA) susceptibility.

Methods: CMB, wanfang (Chinese) and PubMed databases were searched to get the studies on the association between 1858C/T polymorphism and RA susceptibility, and odds ratio (OR) and 95% confidential interval (CI) were calculated under different genetic models. Then heterogeneity, stratified analysis, and publication bias test were conducted in the study.