Publications by authors named "Guoping Li"

Objective: Currently, there has been no gold standard for diagnosing small airway dysfunction (SAdf). This study aimed to evaluate the correlation between small airway parameters derived from spirometry and oscillometry in hospitalized patients, assessing the potential of oscillometry as an alternative diagnostic tool for SAdf. Additionally, this study explored the inconsistencies and influencing factors related to spirometry and oscillometry in diagnosing SAdf, conducting a preliminary assessment of these factors.

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The advent of next-generation nonfullerene acceptors (NFAs) has propelled major advances in organic solar cells (OSCs). Here we report an NFA design incorporating CF-terminated side chains having varying -(CH)-CF linker lengths ( = 1, 2, and 3) which introduce new intermolecular interactions, hence strong modulation of the photovoltaic response. We report a systematic comparison and contrast characterization of this NFA series with a comprehensive set of chemical/physical techniques versus the heavily studied third-generation NFA, Y6, revealing distinctive and beneficial properties of this new NFA series.

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The fall armyworm, (Lepidoptera: Noctuidae) (FAW), is an invasive and destructive polyphagous pest that poses a significant threat to global agricultural production. The FAW mainly damages maize, with a particular preference for V3-V5 (third to fifth leaf collar) plant stages in northern China. How the FAW moth precisely locates maize plants in the V3-V5 stage at night remains unclear.

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Introduction: Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment (TME), and their polarization state significantly influences patient outcomes. This study investigates the inhibitory effects of β-glucan extracted from Candida albicans on lung cancer progression, focusing on its impact on TAM polarization and the induction of ferroptosis, a form of regulated cell death.

Methods: Utilizing both in vivo animal models and in vitro cellular assays, we assessed the impact of β-glucan on tumor growth, cellular proliferation, and migration.

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Asthma, a prevalent chronic respiratory disease, is characterized by airway inflammation and hyperresponsiveness, significantly impacting global health. Current treatments, including corticosteroids, face limitations due to variable patient responses and side effects. This study explores the therapeutic potential of Cistanche, a traditional Chinese medicinal herb, in an asthmatic mouse model induced by house dust mites (HDM).

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We characterized circulating extracellular vesicles (EVs) in obese and lean humans, identifying transcriptional cargo differentially expressed in obesity. Since circulating EVs may have broad origin, we compared this obesity EV transcriptome to expression from human visceral adipose tissue derived EVs from freshly collected and cultured biopsies from the same obese individuals. Using a comprehensive set of adipose-specific epigenomic and chromatin conformation assays, we found that the differentially expressed transcripts from the EVs were those regulated in adipose by BMI-associated SNPs from a large-scale GWAS.

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Article Synopsis
  • The study investigates the impact of collagen content on survival in solitary fibrous tumors (SFTs) of the central nervous system (CNS) and its connection to MRI features.
  • Collagen levels were measured using staining techniques, with results showing that higher collagen content correlates positively with overall survival, and it acts as an independent prognostic factor.
  • The research found that MRI features and radiomic models, particularly T1- and T2-weighted imaging, can effectively assess collagen content, potentially improving diagnostic accuracy for CNS SFTs.
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A mild and environmentally friendly photocatalytic method for C-C bond formation between 1,3-dicarbonyls and styrene derivatives has been developed in a green solvent - ethanol. A series of α-functionalized β-diketones were obtained in moderate to good yields. Based on the results of control experimental and theoretical calculations, the photocatalytic transformation might be accomplished by generating reactive radicals a single electron transfer process.

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To investigate the effect of phosphorylated HSP27 on the proliferation and metastasis of nasopharyngeal carcinoma and its molecular mechanism. ①Western blot assay was used to detect the expression levels of HSP27 and p-HSP27 in CNE1 and CNE2 cells of nasopharyngeal carcinoma. Inhibited the phosphorylation of HSP27, Transwell assay detected the metastasis ability of nasopharyngeal carcinoma cells.

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The oriental armyworm, , generally migrates from eastern to northeastern China in early summer, and some individuals are believed to migrate overseas to Japan depending on meteorological conditions. This potential migration was investigated with the immigrants' strontium radiogenic isotope ratio Sr/Sr and backward flight trajectories from Japanese trapping sites. The results showed that the Sr/Sr ratios of Chinese reared were significantly higher than those of reared insects of Japanese immigration areas.

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Climate change driving by greenhouse gas emissions from petroleum-based energy has garnered significant attention. Renewable energy production via a sustainable system that integrates the cell factory and visible-light-driven photocatalysts offers a novel approach for upcycling methane and addressing global energy challenges. Here, an auto-activated biohybrid system driven by solar energy is developed for converting methane into hydrogen fuel, which incorporated thienoviologen (S-MV) and genetically engineered methanotrophic bacteria.

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Force-sensing biophysical cues in microenvironment, including extracellular matrix performances, stretch-mediated mechanics, shear stress and flow-induced hemodynamics, have a significant influence in regulating vascular morphogenesis and cardiac remodeling by mechanotransduction. Once cells perceive these extracellular mechanical stimuli, Piezo activation promotes calcium influx by forming integrin-adhesion-coupling receptors. This induces robust contractility of cytoskeleton structures to further transmit biomechanical alternations into nuclei by regulating Hippo-Yes associated protein (YAP) signaling pathway between cytoplasmic and nuclear translocation.

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, also known as the fall armyworm (FAW), is classified by the Food and Agriculture Organization of the United Nations (FAO) as a major agricultural pest. By gaining a more nuanced understanding of the fall armyworm's courtship behavior, simpler and more environmentally friendly methods of controlling this pest can be developed. This study used the Track 3D system to meticulously record and describe the activity characteristics and patterns of adult males and females during courtship.

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The fall armyworm Spodoptera frugiperda (J.E. Smith; Lepidoptera: Noctuidae) is a notorious invasive insect pest.

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Article Synopsis
  • Researchers have identified a specific circular RNA, circDdb1, that plays a significant role in causing skeletal muscle atrophy, which is often linked to aging and various diseases.
  • CircDdb1 levels are significantly increased during muscle atrophy, and adding it artificially leads to more atrophy, whereas its inhibition can prevent muscle loss caused by different factors.
  • The study also finds that circDdb1 regulates protein translation via its interaction with eukaryotic elongation factor 2 (eEF2) and suggests that targeting circDdb1 could serve as a new therapeutic approach to combat muscle atrophy.
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The recent invasion of the fall armyworm (FAW) into Asia not only has had a major impact on maize yield but is feared to also pose a risk to rice production. We hypothesized that the brown planthopper (BPH) may aggravate this risk based on a recently discovered mutualism between the planthopper and the rice striped stem borer. Here we show that BPH may indeed facilitate a shift of FAW to rice.

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  • Oxalate nephropathy involves calcium oxalate crystals that cause damage to renal cells and trigger inflammation; the exact mechanisms, particularly relating to immune cell involvement, are not fully understood.
  • This study tested the hypothesis that NINJ1, which causes membrane rupture and releases inflammatory signals, plays a key role in worsening kidney damage during oxalate nephropathy.
  • Results show that deleting Ninj1 in immune cells reduces kidney injury by lowering harmful signals and cell death, highlighting the importance of NINJ1 in this type of kidney disease.
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The IDH1-R132H mutation is implicated in the development of various tumors. Whether cisplatin, a common chemotherapeutic agent, induces more significant renal toxicity in individuals with the IDH1-R132H mutation remains unclear. In this study, we observed that the IDH1-R132H mutation exacerbates mitochondrial lipid peroxidation and dysfunction in renal tubules, rendering the kidneys more susceptible to cisplatin-induced ferroptosis.

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  • C. psittaci pneumonia often presents atypical symptoms, leading to underdiagnosis, so this study aimed to analyze clinical characteristics and develop a prediction model for patient outcomes.
  • A multicenter study across ten Chinese hospitals included data from 119 patients to identify risk factors for serious outcomes like death and ICU admission, using statistical analyses to create predictive models.
  • The final predictive model demonstrated strong discriminatory power and clinical utility, highlighting key factors like serum albumin and CURB-65, which could help clinicians manage C. psittaci pneumonia more effectively.
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Objective To identify the risk factors of patients with frequent acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and construct a prediction model based on the clinical data,providing a theoretical basis for the clinical prevention and treatment. Methods A total of 25 638 COPD patients admitted to the Department of Respiratory and Critical Care Medicine,the Third People's Hospital of Chengdu from January 1,2013 to May 1,2023 were selected.Among them,11 315 patients were included according to the inclusion and exclusion criteria,and their clinical characteristics were analyzed.

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Pulmonary arterial hypertension (PAH) is associated with aberrant pulmonary vascular smooth muscle cell (PASMC) function and vascular remodeling. MiR-30d plays an important role in the pathogenesis of several cardiovascular disorders. However, the function of miR-30d in PAH progression remained unknown.

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Lung squamous cell carcinoma (LUSC) is a malignancy with limited therapeutic options. Immunogenic cell death (ICD) has the potential to enhance the efficacy of cancer therapy by triggering immune responses. We aimed to explore the potential of ICD-based classification in predicting prognosis and response to immunotherapy for LUSC.

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Exercise training (ET) is an important non-drug adjuvant therapy against many human diseases, including cardiovascular diseases. The appropriate ET intensity induces beneficial adaptions and improves physiological function and cardiopulmonary fitness. The mechanisms of exercise-induced cardioprotective effects are still not fully understood.

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